메뉴 건너뛰기




Volumn 74, Issue 5, 2013, Pages 1370-1375

Dexmedetomidine suppresses proinflammatory mediator production in human whole blood in vitro

Author keywords

cytokine; dexmedetomidine.; Immune response; intensive care; pharmacology

Indexed keywords

DEXMEDETOMIDINE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; YOHIMBINE;

EID: 84877062348     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31828db978     Document Type: Article
Times cited : (48)

References (20)
  • 3
    • 0035029189 scopus 로고    scopus 로고
    • Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery
    • Kawasaki T, Ogata M, Kawasaki C, Tomihisa T, Okamoto K, Shigematsu A. Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. Anesth Analg. 2001;92:1322-1326.
    • (2001) Anesth Analg , vol.92 , pp. 1322-1326
    • Kawasaki, T.1    Ogata, M.2    Kawasaki, C.3    Tomihisa, T.4    Okamoto, K.5    Shigematsu, A.6
  • 6
    • 11444253457 scopus 로고    scopus 로고
    • Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: Haemodynamic effects and efficacy
    • Ickeringill M, Shehabi Y, Adamson H, Ruettimann U. Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: haemodynamic effects and efficacy. Anaesth Intensive Care. 2004;32:741-745.
    • (2004) Anaesth Intensive Care , vol.32 , pp. 741-745
    • Ickeringill, M.1    Shehabi, Y.2    Adamson, H.3    Ruettimann, U.4
  • 7
    • 2942565800 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxininduced shock in rats
    • Taniguchi T, Kidani Y, Kanakura H, Takemoto Y, Yamamoto K. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxininduced shock in rats. Crit Care Med. 2004;32:1322-1326.
    • (2004) Crit Care Med , vol.32 , pp. 1322-1326
    • Taniguchi, T.1    Kidani, Y.2    Kanakura, H.3    Takemoto, Y.4    Yamamoto, K.5
  • 8
    • 0032845356 scopus 로고    scopus 로고
    • Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro
    • Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg. 1999;89:665-669.
    • (1999) Anesth Analg , vol.89 , pp. 665-669
    • Kawasaki, T.1    Ogata, M.2    Kawasaki, C.3    Ogata, J.4    Inoue, Y.5    Shigematsu, A.6
  • 9
    • 70349742451 scopus 로고    scopus 로고
    • Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    • Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009; 21:394-400.
    • (2009) J Clin Anesth , vol.21 , pp. 394-400
    • Tasdogan, M.1    Memis, D.2    Sut, N.3    Yuksel, M.4
  • 10
    • 0035030213 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit
    • Venn RM, Bryant A, Hall GM, Grounds RM. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. Br J Anaesth. 2001;86:650-656.
    • (2001) Br J Anaesth , vol.86 , pp. 650-656
    • Venn, R.M.1    Bryant, A.2    Hall, G.M.3    Grounds, R.M.4
  • 11
    • 0034694224 scopus 로고    scopus 로고
    • The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products
    • Maes M, Lin A, Kenis G, Egyed B, Bosmans E. The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products. Psychiatry Res. 2000;96:245-253.
    • (2000) Psychiatry Res , vol.96 , pp. 245-253
    • Maes, M.1    Lin, A.2    Kenis, G.3    Egyed, B.4    Bosmans, E.5
  • 12
    • 67349257928 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages
    • Lai YC, Tsai PS, Huang CJ. Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages. J Surg Res. 2009;154:212-219.
    • (2009) J Surg Res , vol.154 , pp. 212-219
    • Lai, Y.C.1    Tsai, P.S.2    Huang, C.J.3
  • 13
    • 67650493786 scopus 로고    scopus 로고
    • Novel HMGB1-inhibiting therapeutic agents for experimental sepsis
    • Wang H, Ward MF, Sama AE. Novel HMGB1-inhibiting therapeutic agents for experimental sepsis. Shock. 2009;32:348-357.
    • (2009) Shock , vol.32 , pp. 348-357
    • Wang, H.1    Ward, M.F.2    Sama, A.E.3
  • 15
    • 0033623230 scopus 로고    scopus 로고
    • Clinical uses of alpha2-adrenergic agonists
    • Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology. 2000;93:1345-1349.
    • (2000) Anesthesiology , vol.93 , pp. 1345-1349
    • Kamibayashi, T.1    Maze, M.2
  • 16
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey KJ. The inflammatory reflex. Nature. 2002;420:853-859.
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 17
    • 0027299384 scopus 로고
    • The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers
    • Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL. The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. 1993;78:813-820.
    • (1993) Anesthesiology , vol.78 , pp. 813-820
    • Dyck, J.B.1    Maze, M.2    Haack, C.3    Vuorilehto, L.4    Shafer, S.L.5
  • 18
  • 19
    • 33750464516 scopus 로고    scopus 로고
    • Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects
    • quiz 1069-1070
    • Snapir A, Posti J, Kentala E, Koskenvuo J, Sundell J, Tuunanen H, Hakala K, Scheinin H, Knuuti J, Scheinin M. Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects. Anesthesiology. 2006;105:902-910; quiz 1069-1070.
    • (2006) Anesthesiology , vol.105 , pp. 902-910
    • Snapir, A.1    Posti, J.2    Kentala, E.3    Koskenvuo, J.4    Sundell, J.5    Tuunanen, H.6    Hakala, K.7    Scheinin, H.8    Knuuti, J.9    Scheinin, M.10
  • 20
    • 25644446101 scopus 로고    scopus 로고
    • Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritisinduced pain
    • Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritisinduced pain. J Neurosci. 2005;25:8988-8994.
    • (2005) J Neurosci , vol.25 , pp. 8988-8994
    • Romero-Sandoval, E.A.1    McCall, C.2    Eisenach, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.