Development of p-carborane-based nonsteroidal progesterone receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5329-5337

  Fujii, Shinya ^a,b   Nakano, Eiichi ^a   Yanagida, Naoki ^a   Mori, Shuichi ^a   Masuno, Hiroyuki ^a   Kagechika, Hiroyuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antagonist; Carborane; Nonsteroid; Nuclear receptor; Progesterone

Indexed keywords

1 (3 CYANOPHENYL) 12 (CYCLOPROPYLCARBONYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (1 HYDROXY 2 METHYLPROPYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (1 HYDROXYETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (1 HYDROXYHEXYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (1 HYDROXYPROPYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 HYDROXY 2 PHENETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 HYDROXYBUTYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 HYDROXYPROPYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 OXO 2 PHENETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 OXOBUTYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (2 OXOPROPYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (ALPHA HYDROXYBENZYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (CYCLOPROPYLCARBONYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (CYCLOPROPYLHYDROXYMETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (ISOBUTYRYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 CYANOPHENYL) 12 (PROPIONYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 METHOXYPHENYL) 12 (1 HYDROXYCYCLOPROPYLMETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 NITROPHENYL) 12 (1 HYDROXYCYCLOPROPYLMETHYL) 1,12 DICARBACLOSODODECABORANE; 1 (4 TRIFLUOROMETHYLPHENYL) 12 (1 HYDROXYCYCLOPROPYLMETHYL) 1,12 DICARBACLOSODODECABORANE; 1 ACETYL 12 (4 CYANOPHENYL) 1,12 DICARBACLOSODODECABORANE; 1 BENZOYL 12 (4 CYANOPHENYL) 1,12 DICARBACLOSODODECABORANE; ANDROGEN RECEPTOR; ANTIGESTAGEN; CARBORANE DERIVATIVE; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG; BORANE DERIVATIVE; NITRILE;

ARTICLE; BINDING AFFINITY; CANCER CELL; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; IC50; PHARMACOPHORE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; FEMALE; HUMAN; MOLECULAR DOCKING; SYNTHESIS; TUMOR CELL CULTURE;

BORANES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NITRILES; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84907532440     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.049     Document Type: Article

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