Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5220-5233

  Endo, Satoshi ^a   Hu, Dawei ^b   Matsunaga, Toshiyuki ^a   Otsuji, Yoko ^a   El Kabbani, Ossama ^c   Kandeel, Mahmoud ^d,e   Ikari, Akira ^a   Hara, Akira ^d   Kitade, Yukio ^d   Toyooka, Naoki ^b  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c MONASH UNIVERSITY   (Australia)

^d GIFU UNIVERSITY   (Japan)

^e KING FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

AKR1C3; Aldo keto reductase; Baccharin; Cancer; Inhibitor; Selectivity

Indexed keywords

3 [3 (BUT 2 EN 1 YLOXY) 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 BENZYLOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 BUTOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 ETHOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 ISOBUTOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 ISOPROPOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 METHOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 PHENETHOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 PROPOXY 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(2 FLUOROBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(2 METHYLALLYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [[3 (2,4,6 TRIFLUOROPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [[3 (3 FLUOROPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [[3 (3 HYDROXYPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [[3 (4 FLUOROPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3 FLUOROBENZYL)OXY] 4 [[3 (4 HYDROXYPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [3 [(3,5 DIFLUOROBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(4 CHLOROBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(4 FLUOROBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(4 METHYLBENZYL)OXY] 4 [(3 PHENYLPROPANOYL)OXY]PHENYL]ACRYLIC ACID; 3 [3 [(4 METHYLBENZYL)OXY] 4 [[3 (2,4,6 TRIFLUOROPHENYL)PROPANOYL]OXY]PHENYL]ACRYLIC ACID; 3 [4 [[3 (3 FLUOROPHENYL)PROPANOYL]OXY] 3 [(4 METHYLBENZYL)OXY]PHENYL]ACRYLIC ACID; 3 [4 [[3 (3 HYDROXYPHENYL)PROPANOYL]OXY] 3 [(4 METHYLBENZYL)OXY]PHENYL]ACRYLIC ACID; 3 [4 [[3 (4 FLUOROPHENYL)PROPANOYL]OXY] 3 [(4 METHYLBENZYL)OXY]PHENYL]ACRYLIC ACID; ALDO KETO REDUCTASE INHIBITOR; ANTINEOPLASTIC AGENT; BACCHARIN; NATURAL PRODUCT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME INHIBITION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN;

EID: 84907518532     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.08.007     Document Type: Article

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