Expression of interleukins 7 & 8 in peripheral blood mononuclear cells from patients with metabolic syndrome: A preliminary study

Indian Journal of Medical Research

Volumn 140, Issue AUG 2014, 2014, Pages 238-243

  Saidijam, M ^a   Tootoonchi, A S ^a   Goodarzi, M T ^a   Hassanzadeh, T ^a   Borzuei, S H ^b   Yadegarazari, R ^a   Shabab, N ^a  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gene expression; IL 7; IL 8; Metabolic syndrome; PBMC; Real time PCR

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 7; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; CHOLESTEROL; GLUCOSE BLOOD LEVEL; PRIMER DNA; TRIACYLGLYCEROL;

ADULT; ANALYTIC METHOD; ARTICLE; CELL ISOLATION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; METABOLIC SYNDROME X; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL; NONPARAMETRIC TEST; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHOLESTEROL; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-7; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; METABOLIC SYNDROME X; REAL-TIME POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES;

EID: 84907515735     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Sookoian S, Pirola CJ. Genetics of the cardiometabolic syndrome: new insights and therapeutic implications. Ther Adv Cardiovasc Dis 2007; 1: 37-47.
2. Shin MJ, Lee KH, Chung JH, Park YK, Choi MK, Oh J, et al. Circulating IL-8 levels in heart failure patients with and without metabolic syndrome. Clin Chim Acta 2009; 405: 139-42.
3. Ford ES, Li C, Cook S, Choi HK. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 2007; 115: 2526-32.
4. Warnberg J, Marcos A. Low-grade inflammation and the metabolic syndrome in children and adolescents. Curr Opin Lipidol 2008; 19: 11-5.
5. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001; 24: 683-9.
6. Ford ES, Giles WH, Dietz WH. Prevalence of metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-9.
7. Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14: 1132-43.
8. Camargo A, Ruano J, Fernandez JM, Parnel LD, Jimenez A, Santos-Gonzalez M, et al. Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics 2010; 11: 253.
9. Bosello O, Zamboni M. Visceral obesity and metabolic syndrome. Obes Rev 2000; 1: 47-56.
10. Pop-Busui R, Pietropaolo M. Metabolic syndrome and inflammation. In: Eisenbarth GS, editor.Immunoendocrinology: Scientific and clinical aspects. Totowa, NJ: Humana Press; 2011. p. 69-92.
11. Sandhofer A, Kaser S, Ritsch A, Laimer M, Engl J, Paulweber B, et al. Cholesteryl ester transfer protein in metabolic syndrome. Obesity (Silver Spring) 2006; 14: 812-8.
12. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002; 288: 2709-16.
13. Pischon T, Hu FB, Rexrode KM, Girman CJ, Manson JE, Rimm EB. Inflammation, the metabolic syndrome, and the risk of coronary heart disease in women and men. Atherosclerosis 2008; 197: 392-9.
14. Shim WS, Kim HJ, Kang ES, Ahn CW, Lim SK, Lee HC, et al. The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients. Diabetes Res Clin Pract 2006; 73: 284-91.
15. Wang Z, Nakayama T. Inflammation, A link between obesity and cardiovascular disease. Mediators Inflamm. Available from: http://www.hindawi.com/journals/mi/2010/535918.
16. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-808.
17. Odegaard JI, Chawla A. Mechanisms of macrophage activation in obesity induced insulin resistance. Nat Clin Pract Endocrinol Metab 2008; 4: 619-26.
18. Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol 2010; 184: 3461-9.
19. Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 2008; 111: 2101-11.
20. Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA, Boussiotis VA. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med 2004; 200: 659-69.
21. Bikker A, van Woerkom JM, Kruize AA, Wenting-van Wijk M, de Jager W, Bijlsma JW, et al. Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjogren’s syndrome correlates with increased inflammation. Arthritis Rheum 2010; 62: 969-77.
22. Lucas ST, Aront S, Magnan C, Fauconnier L, Delacre M, Macia L, et al. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 2012; 7: e40351.
23. Kim HJ, Byun SJ, Kim TY. Differential regulation of IGF-II- induced IL-8 by extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinases in human keratinocytes. Biochem Biophys Res Commun 2004; 317: 276-84.
24. Herder C, Haastert B, Müller-Scholze S, Koenig W, Thorand B, Holle R, et al. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Diabetes 2005; 54 (Suppl 2): S11-7.
25. Zozulinska D, Majchrzak A, Sobieska M, Wiktorowicz K, Wierusz-Wysocka B. Serum interleukin-8 level is increased in diabetic patients. Diabetologia 1999; 42: 117-8.
26. Bruun JM, Lihn AS, Madan AK, Pedersen SB, Schiøtt KM, Fain JN, et al. Higher production of IL-8 in visceral vs subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab 2004; 286: E8-13.
27. Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: Report of the Iranian National Committee of Obesity. Arch Iran Med 2010; 13: 426-8.
28. Nilsson C, Aboud S, Karlén K, Hejdeman B, Urassa W, Biberfeld G. Optimal blood mononuclear cell isolation procedures for gamma interferon enzyme-linked immunospot testing of healthy Swedish and Tanzanian subjects. Clin Vaccine Immunol 2008; 154: 585-9.
29. -ΔΔct. Methods 2001; 25: 402-8.
30. Chehtane M, Khaled AR. Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. Am J Physiol Cell Physiol 2010; 298: C1560-C71.
31. Kim MS, Lim WK, Park RK, Shin T, Yoo YH, Hong SH, et al. Involvement of mitogen-activated protein kinase and NF-kB activation in Ca2+ -induced IL-8 production in human mast cells. Cytokine 2005; 32: 226-33.
32. Kuhns DB, Young HA, Gallin EK, Gallin JI. Ca2+-dependent production and release of IL-8 in human neutrophils. J Immunol 1998; 161: 4332-9.