Advances in the discovery of small-molecule IRAK4 inhibitors

Annual Reports in Medicinal Chemistry

Volumn 49, Issue , 2014, Pages 117-133

  Hynes, John ^a   Nair, Satheesh K ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b BMS Biocon Research Center   (India)

Author keywords

IL 1; IRAK4; Lupus; MyD88; Rheumatoid arthritis; Toll like receptor

Indexed keywords

EID: 84907508993     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800167-7.00009-2     Document Type: Chapter

References (54)

1. Li S., Strelow A., Fontana E.J., Wesche H. PNAS 2002, 99:5567.
2. Lin S., Lo Y., Wu H. Nature 2010, 465:885.
3. Ku C.-L., Bernuth H., Picard C., Zhang S.-Y., Chang H.-H., Yang K., Chrabieh M., Issekutz A.C., Cunningham C.K., Gallin J., Holland S.M., Roifamn C., Ehl S., Smart J., Tang M., Barrat F.J., Levy O., McDonald D., Day-Good N.K., Miller R., Takada H., Hara T., Al-Hajjar S., Al-Ghonaium A., Speert D., Sanlaville D., Li X., Geissman F., Vivier E., Marodi L., Garty B.-Z., Chapel H., Rodriguez-Gallego C., Bossuyt X., Abel L., Puel A., Casanova J.-L.J. Exp. Med. 2007, 204:2407.
4. Picard C., Casanova J.-L., Puel A. Clin. Microbiol. Rev. 2011, 24:490.
5. Lye E., Dhanji S., Calzascia T., Elford A.R., Ohashi P.S. Eur. J. Immunol. 2008, 38:870.
6. Kim T.W., Febbraio M., Robinet P., DuGar B., Greene D., Cerny A., Latz E., Gilmour R., Staschke K., Chisolm G., Fox P.L., DiCorleto P.E., Smith J.D., Li X.J. Immunol. 2011, 186:2871.
7. Staschke K.A., Dong S., Saha J., Zhao J., Brooks N.A., Hepburn D.L., Xia J., Gulen M.F., Kang Z., Altuntas C.Z., Tuohy V.K., Gilmour R., Li X., Na S.J. Immunol. 2009, 183:568.
8. Koziczak-Holbro M., Littlewood-Evans A., Pöllinger B., Kovarik J., Dawson J., Zenke G., Burkhart C., Müller M., Gram H. Arthritis Rheum. 2009, 60:1661.
9. Goh F.G., Midwood K.S. Rheumatology 2012, 51:7.
10. Miller L.S. Adv. Dermatol. 2008, 24:71.
11. Kim W.-U., Sreih A., Bucula R. Autoimmun. Rev. 2009, 8:204.
12. Cario E. Inflamm. Bowel Dis. 2010, 16:1583.
13. Kimball A.B., Krueger J., Sullivan T., Arbeit R.D. 2013.
14. Bhagat L., Jiang W., Yu D., Arbeit R.D., Sullivan T. FOCIS 2013, 2013, Boston, MA. Presentation Number S.85.
15. Idera Pharmaceuticals 2014, Press Release, March 28. http://www.iderapharm.com.
16. Dinarello C.A., Simon A., van der Meer J.W.M. Nat. Rev. Drug Discov. 2012, 11:633.
17. Ngo V.N., Young R.M., Schmitz R., Jhavar S., Xiao W., Lim K.H., Kohlhammer H., Xu W., Yang Y., Zhao H., Shaffer A.L., Romesser P., Wright G., Powell J., Rosenwald A., Muller-Hermelink H.K., Ott G., Gascoyne R.D., Connors J.M., Rimsza L.M., Campo E., Jaffe E.S., Delabie J., Smeland E.B., Fisher R.I., Braziel R.M., Tubbs R.R., Cook J.R., Weisenburger D.D., Chan W.C., Staudt L.M. Nature 2011, 470:115.
18. Puente X.S., Pinyol M., Quesada V., Conde L., Ordóñez G.R., Villamor N., Escaramis G., Jares P., Beà S., González-Díaz M., Bassaganyas L., Baumann T., Juan M., López-Guerra M., Colomer D., Tubío J.M., López C., Navarro A., Tornador C., Aymerich M., Rozman M., Hernández J.M., Puente D.A., Freije J.M., Velasco G., Gutiérrez-Fernández A., Costa D., Carrió A., Guijarro S., Enjuanes A., Hernández L., Yagüe J., Nicolás P., Romeo-Casabona C.M., Himmelbauer H., Castillo E., Dohm J.C., de Sanjosé S., Piris M.A., de Alava E., San Miguel J., Royo R., Gelpí J.L., Torrents D., Orozco M., Pisano D.G., Valencia A., Guigó R., Bayés M., Heath S., Gut M., Klatt P., Marshall J., Raine K., Stebbings L.A., Futreal P.A., Stratton M.R., Campbell P.J., Gut I., López-Guillermo A., Estivill X., Montserrat E., López-Otín C., Campo E. Nature 2011, 475:101.
19. Treon S.P., Xu L., Yang G., Zhou Y., Liu Z., Cao Y., Sheehy P., Manning R.J., Patterson C.J., Tripsas C., Arcaini L., Pinkus G., Rodig S.J., Sohani A.R., Harris N.L., Laramie J.M., Skifter D.A., Lincoln S.E., Hunter Z.R. NEJM 2012, 367:826.
20. Chaudhary D., Wood N., Romero D.L., Robinson S.D., Greenwood J.R., Shelley M., Morin M., Kapeller R., Westlin W.F. 2013.
21. Kelly P.N., Chaudhary D., Young R.M., Shaffer A., Robinson S., Romero D.L., Kapeller R., Staudt L.M. 2014.
22. Srivastava R., Geng D., Liu Y., Zheng L., Li Z., Joseph M.A., McKenna C., Bansal N., Ochoa A., Davila E. Cancer Res. 2012, 72:6209.
23. Flannery S., Bowie A.G. Biochem. Pharmacol. 2010, 80:1981.
24. Wang Z., Liu J., Sudom A., Ayres M., Li S., Wesche H., Powers J.P., Walker N.P.C. Structure 2006, 14:1835.
25. Kuglstatter A., Villsenor A.G., Shaw D., Lee S.W., Tsing S., Niu L., Song K.W., Barnett J.W., Browner M.F.J. Immunol. 2007, 178:2641.
26. Wang Z., Wesche H., Stevens T., Walker N., Yeh W.-C. Curr. Top. Med. Chem. 2009, 9:724.
27. Powers J.P., Li S., Jaen J.C., Liu J., Walker N.P.C., Wang Z., Wesche H. Bioorg. Med. Chem. Lett. 2006, 16:2842.
28. Frenkel, A.D.; Lively, S.E.; Powers, J.P.; Smith, A.; Sun, D.; Tomooka, C.; Wang, Z. Patent Application US 2007/0037803, 2007.
29. Guckian, K.; Jewell, C.; Conlon, P.; Lin, E.Y.S.; Chan, T. US Patent 8,293,923, 2012.
30. Calderini, M.; Wucherer-Plietker, M.; Graedler, U.; Esdar. C. Patent Application US 2012/0115861, 2012.
31. Buckley G.M., Gowers L., Higueruelo A.P., Jenkins K., Mack S.R., Morgan T., Parry D.M., Pitt W.R., Rausch O., Richard M.D., Sabin V., Fraser J.L. Bioorg. Med. Chem. Lett. 2008, 18:3211.
32. Inami H., Mizutani T., Watanabe J., Usuda H., Nagashima S., Ito T., Aoyama N., Kontani T., Hayashida H., Terasawa T., Moritomo A., Ishikawa T., Hayashi K., Takeuchi M., Ohta M. 2011.
33. Ishikawa T., Imamura E., Mizuhara H., Iwaoka H., Evelyn E., Inami H., Mizutani T., Watanabe J., Usuda H., Nagashima S., Ito T., Kontani T., Shimizu Y., Mutoh S. 2011.
34. Arora, N.; Chen, S.; Hermann, J.; Kuglstatter, A.; Labadie, S.S.; Lin, C.; Lucas, M.C.; Moore, A.G.; Papp, E.; Talamas, F.X.; Wanner, J.; Zhai, Y. Patent Application WO 2012/007375, 2012.
35. McElroy, W.T.; Li, G.; Ho, G.D.; Tan, Z.; Paliwal, S.; Seganish, W.M.; Tulshian, D.; Lampe, J.; Methot, J.L.; Zhou, H.; Altman, M.D.; Zhu, L. Patent Application WO 2012/129258, 2012.
36. Buckley G.M., Ceska T.A., Fraser J.L., Gowers L., Groom C.R., Higueruelo A.P., Jenkins K., Mack S.R., Morgan T., Parry D.M., Pitt W.R., Rausch O., Richard M.D., Sabin V. Bioorg. Med. Chem. Lett. 2008, 18:3291.
37. Buckley G.M., Fosbeary R., Fraser J.L., Gowers L., Higueruelo A.P., James L.A., Jenkins K., Mack S.R., Morgan T., Parry D.M., Pitt W.R., Rausch O., Richard M.D., Sabin V. Bioorg. Med. Chem. Lett. 2008, 18:3656.
38. Dodd, D.; Mussari, C.P.; Bhide, R.S.; Nair, S.K.; Paidi, V.R.; Kumar, S.R.; Banerjee, A.; Sistla, R.; Pitts, W.J.; Hynes, J. Patent Application WO 2013/106614, 2013.
39. Paidi, V.R.; Kumar, S.R.; Nair, S.K.; Banerjee, A.; Sistla, R.; Pitts, W.J.; Hynes, J. Patent Application WO 2013/106641, 2013.
40. Paidi, V.R.; Kumar, S.R.; Banerjee, A.; Nair, S.K.; Sistla, R.; Pitts, W.J.; Hynes, J. Patent Application WO 2013/106612, 2013.
41. Ho, K.-K.; Diller, D.; Letourneau, J.J.; McGuinness, B.F.; Cole, A.G.; Rosen, D.; van Oeveren, C.A.; Pickens, J.C.; Zhi, L.; Shen, Y.; Pedram, B. Patent Application WO 2012/068546, 2012.
42. Vajda E.J., Lin T.H., Wang B., Ho K.-K., van Oeveren A., McGuinness B., Letourneau J., Lee Y.-H., Rungta D., Zhi L., Marschke K.B. 2011.
43. Harriman, G.C.; Wester, R.C.; Romero, D.L.; Robinson, S.; Shelley, M.; Wessel, M.D.; Greenwood, J.R.; Masse, C.E. Patent Application WO 2013/106535, 2013.
44. Divya Chaudhary D., Robinson D., Masse C.E., Wessel M.D., Watts S., Greenwood J., Shelley M., Brewer M., Harriman G., Frye L.L., Wester R.T., Kapeller R., Romero D. 2012.
45. Romero, D.L.; Robinson, S.; Wessel, M.D.; Greenwood, J.R. Patent Application WO 2014/011902, 2014.
46. Harriman, G.C.; Wester, R.C.; Romero, D.L.; Masse, C.E.; Robinson, S.; Greenwood, J.R. Patent Application WO 2014/011906, 2014.
47. Harriman, G.C.; Romero, D.L.; Masse, C.E.; Robinson, S.; Wessel, M.D.; Greenwood, J.R. Patent Application WO 2014/011911, 2014.
48. Seganish, W.M.; Brumfield, S.N.; Lim, J.; Matasi, J.J.; McElroy, W.T.; Tulshian, D.B.; Lavey, B.J.; Altman, M.D.; Gibeau, C.R.; Lampe, J.W.; Methot, J.; Zhu, L.; Patent Application WO 2013/066729, 2013.
49. Seganish, W.M.; McElroy, W.T.; Brumfield, S.; Herr, J.R.; Yet, L.; Yang, J.; Harding, J.P.; Ho, G.D.; Tulshian, D.B.; Yu, W.; Wong, M.K.C.; Lavey, B.J.; Kozlowski, J.A. Patent Application WO 2014/058685, 2014.
50. Anima, B.; Hosohalli, S.; Subhendu, M. Patent Application WO 2013/042137, 2013.
51. Samajdar S. 2014.
52. Jorand-Lebrun, C.; Crosignani, S.; Dorbais, J.; Grippie-Vallotton, T.; Pretre, A. Patent Application WO 2012/084704, 2012.
53. Crosignani, S.; Jorand-Lebrun, C.; Gerber, P.; Muzerelle, M. Patent Application WO 2014/008992, 2014.
54. Tumey L.N., Rao V., Bhagirath N., Subrath J., Boschelli D.H., Bennett E., Shim J., Goodwin D., Lin L.-L., Telliez J.-B., Murphy E., Shen M. 2011.