Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 795-800

  Zhang, Bo ^a,b   Dai, Jianxin ^a,b,c   Wang, Huaqing ^a   Wei, Huafeng ^a,b   Zhao, Jian ^a,c   Guo, Yajun ^a,b,c   Fan, Kexing ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c National Engineering Research Center for Antibody Medicine   (China)

Author keywords

Bone resorption; Osteoclast survival; Osteopontin; Osteoporosis

Indexed keywords

BONE DENSITY CONSERVATION AGENT; COLONY STIMULATING FACTOR 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 23C3; OSTEOPONTIN; UNCLASSIFIED DRUG; SPP1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL MATURATION; CELL SURVIVAL; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY-INDUCED OSTEOPOROSIS; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE DENSITY; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; OSTEOPOROSIS; OVARIECTOMY; PATHOLOGY; RADIOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BONE DENSITY; BONE RESORPTION; CELLS, CULTURED; FEMALE; GENE EXPRESSION; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C57BL; OSTEOCLASTS; OSTEOPONTIN; OSTEOPOROSIS; OVARIECTOMY; X-RAY MICROTOMOGRAPHY;

EID: 84907504267     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.149     Document Type: Article

References (31)

1. M. Zaidi Skeletal remodeling in health and disease Nat. Med. 13 2007 791 801
2. G.R. Mundy Osteoporosis and inflammation Nutr. Rev. 65 2007 S147 S151
3. S.C. Manolagas Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis Endocr. Rev. 21 2000 115 137
4. S.A. Krum, G.A. Miranda-Carboni, P.V. Hauschka, J.S. Carroll, T.F. Lane, L.P. Freedman, and M. Brown Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival EMBO J. 27 2008 535 545
5. N. Houde, E. Chamoux, M. Bisson, and S. Roux Transforming growth factor-beta 1 (TGF-beta 1) induces human osteoclast apoptosis by up-regulating Bim J. Biol. Chem. 284 2009 23397 23404
6. M. Cicek, A. Vrabel, C. Sturchio, L. Pederson, J.R. Hawse, M. Subramaniam, T.C. Spelsberg, and M.J. Oursler TGF-beta inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways Plos One 6 2011 e17522
7. E.W. Bradley, M.M. Ruan, and M.J. Oursler PAK1 is a novel MEK-independent Raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival J. Cell. Physiol. 217 2008 752 758
8. S.H. Lee, S.E. Lee, C.W. Kim, S.H. Lee, S.W. Kim, K. Kwack, and K. Walsh IL-1 alpha stimulation of osteoclast survival through the PI-3 kinase/Akt and ERK pathways J. Biochem. 131 2002 161 166
9. E. Jimi, I. Nakamura, T. Ikebe, S. Akiyama, N. Takahashi, and T. Suda Activation of NF-kappa B is involved in the survival of osteoclasts promoted by interleukin-1 J. Biol. Chem. 273 1998 8799 8805
10. P.H. Stern Antiresorptive agents and osteoclast apoptosis J. Cell. Biochem. 101 2007 1087 1096
11. K.A. Sutherland, H.L. Rogers, D. Tosh, and M.J. Rogers RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro Arthritis Res. Ther. 11 2009 R58
12. K. Merry, R. Dodds, A. Littlewood, and M. Gowen Expression of osteopontin mRNA by osteoclasts and osteoblasts in modelling adult human bone J. Cell Sci. 104 Pt 4 1993 1013 1020
13. D.T. Denhardt, and M. Noda Osteopontin expression and function: role in bone remodeling J. Cell. Biochem. 1998 92 102
14. T. Ishii, S. Ohshima, T. Ishida, T. Mima, Y. Tabunoki, H. Kobayashi, M. Maeda, T. Uede, L. Liaw, N. Kinoshita, I. Kawase, and Y. Saeki Osteopontin as a positive regulator in the osteoclastogenesis of arthritis Biochem. Biophys. Res. Commun. 316 2004 809 815
15. S.R. Rittling, H.N. Matsumoto, M.D. McKee, A. Nanci, X.R. An, K.E. Novick, A.J. Kowalski, M. Noda, and D.T. Denhardt Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro J. Bone Miner. Res. 13 1998 1101 1111
16. H. Yoshitake, S.R. Rittling, D.T. Denhardt, and M. Noda Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption Proc. Natl. Acad. Sci. U.S.A. 96 1999 8156 8160
17. M. Ishijima, S.R. Rittling, T. Yamashita, K. Tsuji, H. Kurosawa, A. Nifuji, D.T. Denhardt, and M. Noda Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin J. Exp. Med. 193 2001 399 404
18. M. Ishijima, K. Tsuji, S.R. Rittling, T. Yamashita, H. Kurosawa, D.T. Denhardt, A. Nifuji, and M. Noda Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice J. Bone Miner. Res. 17 2002 661 667
19. A. Miyauchi, J. Alvarez, E.M. Greenfield, A. Teti, M. Grano, S. Colucci, A. Zambonin-Zallone, F.P. Ross, S.L. Teitelbaum, and D. Cheresh Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts J. Biol. Chem. 266 1991 20369 20374
20. F.P. Ross, J. Chappel, J.I. Alvarez, D. Sander, W.T. Butler, M.C. Farach-Carson, K.A. Mintz, P.G. Robey, S.L. Teitelbaum, and D.A. Cheresh Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption J. Biol. Chem. 268 1993 9901 9907
21. S.A. Khan, C.A. Lopez-Chua, J. Zhang, L.W. Fisher, E.S. Sorensen, and D.T. Denhardt Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors J. Cell. Biochem. 85 2002 728 736
22. E. Geissinger, C. Weisser, P. Fischer, M. Schartl, and C. Wellbrock Autocrine stimulation by osteopontin contributes to antiapoptotic signalling of melanocytes in dermal collagen Cancer Res. 62 2002 4820 4828
23. R. Zohar, B.Q. Zhu, P. Liu, J. Sodek, and C.A. McCulloch Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway Am. J. Pathol. 287 2004 H1730 H1739
24. Y.H. Hsieh, M.M. Juliana, P.H. Hicks, G. Feng, C. Elmets, L. Liaw, and P.L. Chang Papilloma development is delayed in osteopontin-null mice: implicating an antiapoptosis role for osteopontin Cancer Res. 66 2006 7119 7127
25. E.M. Hur, S. Youssef, M.E. Haws, S.Y. Zhang, R.A. Sobel, and L. Steinman Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells Nat. Immunol. 8 2007 74 83
26. K.X. Fan, J.X. Dai, H. Wang, H.F. Wei, Z.G. Cao, S. Hou, W.Z. Qian, H.Q. Wang, B. Li, J. Zhao, H.J. Xu, C.D. Yang, and Y. Guo Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells Arthritis Rheum. 58 2008 2041 2052
27. H. Kim, H.K. Choi, J.H. Shin, K.H. Kim, J.Y. Huh, S.A. Lee, C.Y. Ko, H.S. Kim, H.I. Shin, H.J. Lee, D. Jeong, N. Kim, Y. Choi, and S.Y. Lee Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice J. Clin. Invest. 119 2009 813 825
28. T. Suda, E. Jimi, I. Nakamura, and N. Takahashi Role of 1 alpha,25-dihydroxyvitamin D-3 in osteoclast differentiation and function D.B. McCormick, J.W. Suttie, C. Wagner, Vitamins and Coenzymes 1997 Pt L 223 235
29. T. Nakashima, and H. Takayanagi Osteoclasts and the immune system J. Bone Miner. Metab. 27 2009 519 529
30. E.M. Gravallese, C. Manning, A. Tsay, A. Naito, C. Pan, E. Amento, and S.R. Goldring Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor Arthritis Rheum. 43 2000 250 258
31. N. Yamamoto, F. Sakai, S. Kon, J. Morimoto, C. Kimura, H. Yamazaki, I. Okazaki, N. Seki, T. Fujii, and T. Uede Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis J. Clin. Invest. 112 2003 181 188