Tazarotene induces apoptosis in human basal cell carcinoma via activation of caspase-8/t-bid and the reactive oxygen species-dependent mitochondrial pathway

DNA and Cell Biology

Volumn 33, Issue 10, 2014, Pages 652-666

  Wu, Chieh Shan ^a,b   Chen, Gwo Shing ^b   Lin, Ping Yi ^c   Pan, I Hong ^d   Wang, San Tang ^e   Lin, Sheng Hao ^c,f   Yu, Hsin Su ^b   Lin, Chi Chen ^c,e,f  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; REACTIVE OXYGEN METABOLITE; SURVIVIN; TAZAROTENE; X LINKED INHIBITOR OF APOPTOSIS; BID PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; CASPASE 3; FAS ASSOCIATED DEATH DOMAIN PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; KERATOLYTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINIC ACID DERIVATIVE; PROTEIN BCL X; SMALL INTERFERING RNA; XIAP PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; CELL CYCLE ARREST; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; BIOSYNTHESIS; CARCINOMA, BASAL CELL; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECTS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; GENETICS; METABOLISM; MITOCHONDRION; NICK END LABELING; PATHOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARCINOMA, BASAL CELL; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; DOWN-REGULATION; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; IN SITU NICK-END LABELING; INHIBITOR OF APOPTOSIS PROTEINS; KERATOLYTIC AGENTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NICOTINIC ACIDS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, DEATH DOMAIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84907500413     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2014.2366     Document Type: Article

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