The apolipoprotein e polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Tejedor, M Teresa ^a   Garcia Sobreviela, Maria Pilar ^b   Ledesma, Marta ^c   Arbones Mainar, Jose M ^b,d  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^c INSTITUTO ARAGONÉS DE CIENCIAS DE LA SALUD   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E2; LIPID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE; ALLELE; APOLIPOPROTEIN E GENE; APOLIPOPROTEIN E2 GENE; ARTICLE; BODY FAT; BODY MASS; GENETIC ASSOCIATION; HOMOZYGOTE; HUMAN; LIPID ANALYSIS; LIPID BLOOD LEVEL; MALE; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; WAIST CIRCUMFERENCE; BLOOD; EXON; GENE EXPRESSION; GENETICS; MULTIVARIATE ANALYSIS; OBESITY; RISK;

ADIPOSITY; ADULT; APOLIPOPROTEINS E; BODY MASS INDEX; CHOLESTEROL, HDL; EXONS; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84907494174     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108605     Document Type: Article

References (26)

1. Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, et al. (2011) Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 377:1085-95.
2. Zechner R, Moser R, Newman TC, Fried SK, Breslow JL (1991) Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content. J Biol Chem 266:10583-8.
3. Huang ZH, Reardon CA, Mazzone T (2006) Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes 55:3394-3402.
4. Arbones-Mainar JM, Johnson LA, Altenburg MK, Maeda N (2008) Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. Int J Obes 32:1595-605.
5. Kuhei DG, Konaniah ES, Basford JE, McVey C, Goodin CT, et al. (2013) Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice. Diabetes 62 (2):382-391.
6. Loos BJF (2012) Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 26:211-26.
7. Donahue R, Orchard T, Kuller L, Drash A (1985) Lipids and lipoproteins in a young adult population: The Beaver County Lipids Study. AmJ Epidemiol 122:458-467.
8. Dallongeville J, Lussier-Cacan S, Davignon J (1992) Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. J Lipid Res 33:447-454.
9. Casasnovas JA, Alcaide V, Civeira F, Guallar E, Ibañez B, et al. (2012) Aragon workers' health study-design and cohort description. BMC Cardiovasc Disord 12:45.
10. Saar K, Geller F, Rüschendorf F, Reis A, Friedel S, et al. (2003) Genome Scan for Childhood and Adolescent Obesity in German Families. Pediatr 111 (2):321327.
11. Guo Y, Shen H, Liu Y, Wang W, Xiong D, et al. (2006) Assessment of Genetic Linkage and Parent-of-Origin Effects on Obesity. J Clin Endocrinol Metab 91 (10):4001-4005.
12. Feitosa MF, Rice T, North KE, Kraja A, Rankinen T, et al. (2006) Pleiotropic QTL on chromosome 19ql3 for triglycerides and adiposity: the HERITAGE Family Study. Atherosclerosis 185:426-432.
13. Mannila MN, Mahdessian H, Franco-Cereceda A, Eggertsen G, de Faire U, et al. (2013) Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration. Arterioscler Thromb Vase Biol 33:1063-9.
14. Volcik KA, Barkley RA, Hutchinson RG, Mosley TH, Heiss G, et al. (2006) Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants. AmJ Epidemiol 164:342-348.
15. Duman BS, Oztürk M, Yilmazer S, Hatemi H (2004) Apolipoprotein E polymorphism in Turkish subjects with Type 2 diabetes mellitus: allele frequency and relation to serum lipid concentrations. Diabetes Nutr Metab 17:267-74.
16. Zeljko H, Skaric-Juric T, Narancic N, Tomas Z, Baresic A, et al. (2011) E2 allele of the Apolipoprotein E gene polymorphism is predictive for obesity status in Roma minority population of Croatia. Lipids Health Dis 10:9.
17. Vucinic N, Djan I, Stokic E, Bozin B, Obreht D, et al. (2014) Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia). Mol Biol Rep 41:5221-5227.
18. Gotdieb DJ, DeStefano AL, Foley DJ, Mignot E, Redline S, et al. (2004) APOE 4 is associated with obstructive sleep apnea/hypopnea: The Sleep Heart Health Study. Neurology 63:664-668.
19. Izaks GJ, Gansevoort RT, Van der Knaap AM, Navis G, Dullaart RPF, et al. (2011) The association of APOE genotype with cognitive function in persons aged 35 years or older. PLoS One 6:e27415.
20. Oh JY, Barrett-Connor E (2001) Apolipoprotein E polymorphism and lipid levels differ by gender and family history of diabetes: the Rancho Bernardo Study. Clin Genet 60:132-7.
21. Alvim RO, Freitas SRS, Ferreira NE, Santos P, Cunha RS, et al. (2010) APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population. Lipids Heal Dis 9:128.
22. Guerra A, Rego C, Castro EMB, Seixas S, Rocha J (2003) Influence of Apolipoprotein E Polymorphism on Cardiovascular Risk Factors in Obese Children. Ann Nutr Metab 47:49-54.
23. Ellis JA, Ponsonby A-L, Pezic A, Williamson E, Cochrane JA, et al. (2011) APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health Survey. PLoS One 6:e26679.
24. Petkeviciene J, Smalinskiene A, Luksiene DI, Jureniene K, Ramazauskiene V, et al (2012) Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population. PLoS One 7:e41525. Utermann G, Pruin N, Steinmetz A (1979) Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man. Clin Genet 15:63-72.
25. Uttermann G, Pruin N, Steinmetz A (1979), Polymorphism of apolipoprotien E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man. Clin Genet 15:63-72.
26. Huang ZH, Maeda N, Mazzone T (2011) Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis. J Lipid Res 52 (9): 1733 -1741.