Influence of apolipoprotein E polymorphism on cardiovascular risk factors in obese children

Annals of Nutrition and Metabolism

Volumn 47, Issue 2, 2003, Pages 49-54

  Guerra, António ^a,b   Rego, Carla ^a   Castro, Elizabete M B ^a   Seixas, Susana ^a   Rocha, Jorge ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

Apolipoprotein E polymorphism; Cardiovascular risk factors; Lipid profile; Obesity, children

Indexed keywords

APOLIPOPROTEIN E; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADOLESCENT; ALLELE; ANTHROPOMETRIC PARAMETERS; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY FAT; BODY MASS; CALCULATION; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MODEL; OBESITY; OSCILLOMETRY; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RISK FACTOR; SOUTHERN EUROPE;

APOLIPOPROTEINS E; BLOOD GLUCOSE; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHILD; CHILD NUTRITION DISORDERS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INSULIN; LIPIDS; MALE; OBESITY; POLYMORPHISM, GENETIC; RISK FACTORS; TRIGLYCERIDES;

EID: 0037233140     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000069275     Document Type: Article

References (47)

1. Morrison JA, Sprecher DL, Barton BA, Waclawiw MA, Daniels SR: Overweight, fat patterning, and cardiovascular disease risk factors in black and white girls: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 1999;135:458-464.
2. Myers L, Coughlin SS, Webber LS, Srinivasan SR, Berenson GS: Prediction of adult cardiovascular multifactorial risk status from childhood risk factor levels: The Bogalusa Heart Study. Am J Epidemiol 1995;142:918-924.
3. Motulsky AG: Nutrition and genetic susceptibility to common diseases. Am J Clin Nutr 1992;55(suppl):1244-1245.
4. Grundy SM, Denke MA: Dietary influences on serum lipids and lipoproteins. J Lipid Res 1990;31:1149-1172.
5. Sanghera DK, Ferrell RE, Aston CE, McAllister AE, Kamboh MI, Kimm SY: Quantitative effects of the apolipoprotein E polymorphism in a biracial sample of 9-10-year-old girls. Atherosclerosis 1996;126:35-42.
6. Srinivasan SR, Ehnholm C, Elkasabany A, Berenson G: Influence of apolipoprotein E polymorphism on serum lipids and lipoprotein changes from childhood to adulthood: The Bogalusa Heart Study. Atherosclerosis 1999;143:435-443.
7. Kallio MJ, Salmenpera L, Siimes MA, Perheentupa J, Gylling H, Miettienen TA: The apolipoprotein E phenotype has a strong influence on tracking of serum cholesterol and lipoprotein levels in children: A follow-up study from birth to the age of 11 years. Pediatr Res 1998;43:381-385.
8. Corbo RM, Scacchi R, Mureddu L, Mulas G, Alfano G: Apolipoprotein E polymorphism in Italy investigated in a native plasma by a simple polyacrylamide gel isoelectric focusing technique: Comparison with frequency data of other European populations. Ann Hum Genet 1995;59:197-209.
9. Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csázár A, Utermann G: The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations. Am J Hum Genet 1991;49:338-349.
10. Kamboh MI, Sepehrnia B, Ferrell RE: Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks. Dis Markers 1989;7:49-55.
11. Utermann G: Apolipoprotein E polymorphism in health and disease. Am Heart J 1987;113:433-440.
12. Parlier G, Thomas G, Bereziat G, Fontaine JL, Girardet JP: Relation of apolipoprotein E polymorphism to lipid metabolism in obese children. Pediatr Res 1997;41:682-685.
13. Sing CF, Davignon J: Role of apolipoprotein E polymorphism in determining normal plasma and lipoprotein variation. Am J Hum Genet 1985;37:268-285.
14. Hamill PV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM: Physical growth: National Center for Health Statistics percentiles. Am J Clin Nutr 1979;32:607-629.
15. Frisancho AR: Anthropometric Standards for the Assessment of Growth and Nutritional Status, ed 4. Ann Arbor, University of Michigan Press, 1993.
16. Lee J, Kolouel N, Hinds W: Relative merits of the weight-corrected-for-height indices. Am J Clin Nutr 1981;34:2521-2529.
17. Abu Khaled M, McCutcheon MJ, Reddy S, Pearman PL, Hunter GR, Weinsier RL: Electrical impedance in assessing human body composition: The BIA method. Am J Clin Nutr 1988;47:789-792.
18. Alain CC, Poon LS, Chan CSG, Richmond W, Fu PC: Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475.
19. Flegg HM: An investigation of the determination of serum cholesterol by an enzymatic method. Am Clin Biochem 1973;10:79.
20. Manual of Laboratory Operations: Lipid Research Clinics Program. Lipid and Lipoprotein Analysis. Bethesda, National Institutes of Health, 1974, vol 1, p 75.
21. Lindgren FT, Jensen LC, Hatch FT: The isolation and quantitative analysis of serum lipoprotein; in Nelson GJ (ed): Blood Lipid and Lipoproteins. New York, Wiley, 1972, pp 181-274.
22. Wenham PR, Price WH, Blandell G: Apolipoprotein E genotyping by one-stage PCR. Lancet 1991;337:1158-1159.
23. Alberti KG, Zimmet PZ, for the WHO Consultation: Definition, diagnosis and classification of diabetes mellitus and its complications. 1. Diagnosis and classification of diabetes mellitus: Provisional report of a WHO consultation. Diabet Med 1998;15:539-553.
24. Haffner SM, Miettinen H, Stern MP: The homeostasis model in the San Antonio Heart Study. Diabetes Care 1997;20:1087-1092.
25. Frohlich ED, Grim C, Labarthe DR, Maxwell MH, Perloff D, Weidman WH: Recommendations for human blood pressure determination by sphygmomanometers: Report of a special task force appointed by the Steering Committee of the American Heart Association. Circulation 1988;77:501-514.
26. Report of the Second Task Force on Blood Pressure Control in Children. Pediatrics 1987;79:1-25.
27. Schneider S, Kueffer JM, Roessli D, Excoffier L: Arlequin ver. 1.1: A Software for Population Genetic Data Analysis. Geneva, University of Geneva, 1997.
28. Seixas S, Trovoada MJ, Rocha J: Haplotype analysis of the apolipoprotein E (APOE) and apolipoprotein C1 (APOC1) loci in Portugal and S. Tomé e Príncipe (Gulf of Guinea): Linkage disequilibrium evidence that apolipoprotein E*4 is the ancestral APOE allele. Hum Biol 1999;71:1001-1008.
29. Guerra A, Rego C, Castro EMB, Seixas S, Rocha J: Association between apolipoprotein E phenotype and lipid profile and adiposity in Portuguese children. Atherosclerosis 2000;151:153.
30. Assman G, Schmitz G, Menzel HJ, Schulte H: Apolipoprotein E polymorphism and hyperlipidemia. Clin Chem 1984;30:641-643.
31. Fumeron F, Rigaud D, Bertiere MC, Bardon S, Dely C, Apfelbaum M: Association of apolipoprotein ε4 allele with hypertriglyceridemia in obesity. Clin Genet 1988;34:258-264.
32. National Cholesterol Education Program (NCEP): Highlights of the report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 1992;89:495-501.
33. Bellù R, Ortisi MT, Scaglioni S, Agostoni C, Salanitri VS, Riva E, Giovannini M: Lipid and apoprotein A-I and B levels in obese school-age children: Results of a study in the Milan area. J Pediatr Gastroenterol Nutr 1993;16:446-450.
34. Kesaniemi YA, Ehnholm C, Miettinen TA: Intestinal cholesterol absorption efficiency in man related to apoprotein E phenotype. J Clin Invest 1987;80:578-581.
35. Miettinen TA, Gylling H, Vanhanen H, Ollus A: Cholesterol absorption, elimination, and synthesis related to low-density lipoprotein kinetics during varying fat intake in men with different apolipoprotein E phenotypes. Arterioscler Thromb 1992;12:1044-1052.
36. Gylling H, Miettinen TA: Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apolipoprotein E phenotypes. J Lipid Res 1992;33:1361-1371.
37. Szalai C, Czinner A, Császár A: Influence of apolipoprotein E genotypes on serum lipid parameters in a biracial sample of children. Eur J Pediatr 2000;159:257-260.
38. Srinivasan SR, Ehnholm C, Wattigney WA, Bao W, Berenson G: The relation of the apolipoprotein E polymorphism to multiple cardiovascular risk in children: The Bogalusa Heart Study. Atherosclerosis 1996;123:33-42.
39. Sveger T, Flodmark CE, Fex G, Henningsen NC: Apolipoproteins A-I and B in obese children. J Pediatr Gastroenterol Nutr 1989;9:497-501.
40. Dahlström S, Viikari J, Akerblom HK, Solakivi-Jaakkola T, Uhari M, Dahl M, Lahde PL, Pesonen E, Pietikainen M, Suoninen P, et al: Atherosclerosis precursors in Finnish children and adolescents. II. Height, weight, body mass index, and skinfolds and their correlation to metabolic variables. Acta Paediatr Scand Suppl 1985;318:65-78.
41. Guerra AJM, Rego C, Castro EMB, Rodrigues P, Silva D, Lourenço S, Bicho M, Carvalho Guerra F, Teixeira Santos N: Estudo prospectivo referente aos principais factores de risco de patologia cardiovascular desde a infância e até à adolescência. Acta Paediatr Port 1997;28:297-306.
42. Srinivasan SR, Ehnholm C, Elkasabany A, Berenson GS: Apolipoprotein E polymorphism modulates the association between obesity and dyslipidemias during adulthood: The Bogalusa Heart Study. Metabolism 2001;50:696-702.
43. Srinivasan SR, Ehnholm C, Elkasabany A, Berenson G: Apolipoprotein E polymorphism and its association with serum lipoprotein concentration in black versus white children: The Bogalusa Heart Study. Metabolism 1993;42:381-386.
44. Mueller WH, Joos SK, Hanis CL, Zalaveta AN, Eichner J, Schull WJ: The Diabetes Alert Study: Growth, fatness, and fat patterning, adolescence through adulthood in Mexican Americans. Am J Phys Anthropol 1984;64:389-399.
45. Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, Adams PW: Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982;54:254-260.
46. Legido A, Sarria A, Bueno M, Garagorri J, Fleta J, Ramos F, Abos MD, Perez-Gonzalez J: Relationship of body fat distribution to metabolic complications in obese prepubertal boys: Gender related differences. Acta Paediatr Scand 1989;78:440-446.
47. Shiwaco K, Gao TQ, Hojo N, Fukushima T, Yamane Y: Low levels of serum cholesterol and systolic blood pressure in Japanese with apolipoprotein E2/3 genotype. Clin Chim Acta 1999;284:15-23.