Postsplenectomy cytomegalovirus mononucleosis is a distinct clinicopathologic syndrome

American Journal of the Medical Sciences

Volumn 339, Issue 4, 2010, Pages 395-399

  Han, Xiang Y ^a   Hellerstedt, Beth A ^b   Koller, Charles A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b TEXAS ONCOLOGY   (United States)

Author keywords

Cytomegalovirus; IgM response; Infectious mononucleosis; Marked lymphocytosis; Splenectomy

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; VIRUS ANTIGEN; VIRUS DNA;

ADULT; ANTIBODY RESPONSE; ANTIGEN DETECTION; ARTICLE; CASE REPORT; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; FEVER; FOLLOW UP; GENE REARRANGEMENT; HEADACHE; HEPATITIS; HUMAN; LYMPHOCYTOSIS; MALAISE; MALE; MEMORY CELL; MONONUCLEOSIS; SPLENECTOMY; CYTOMEGALOVIRUS INFECTION; DIFFERENTIAL DIAGNOSIS; INFECTIOUS MONONUCLEOSIS; POSTOPERATIVE COMPLICATION; REVIEW; SYNDROME; VIROLOGY;

ADULT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DIAGNOSIS, DIFFERENTIAL; HUMANS; INFECTIOUS MONONUCLEOSIS; MALE; POSTOPERATIVE COMPLICATIONS; SPLENECTOMY; SYNDROME;

EID: 77950918769     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3181cfc1d3     Document Type: Article

References (28)

1. Pass RF. Cytomegalovirus. In: Knipe DM, Howley PM, Griffin DE, et al, editors. Fields virology, 4th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2001. p. 2675-2705
2. Just-Nubling G, Korn S, Ludwig B, et al. Primary cytomegalovirus infection in an outpatient setting-laboratory markers and clinical aspects. Infection 2003;31:318-323 (Pubitemid 37260366)
3. Horwitz CA, Henle W, Henle G, et al. Clinical and laboratory evaluation of cytomegalovirus-induced mononucleosis in previous healthy individuals: report of 82 cases. Medicine (Baltimore) 1986;65: 124-134 (Pubitemid 16099672)
4. Okun DB, Tanaka KR. Profound leukemoid reaction in cytomegalovirus mononucleosis. JAMA 1978;240:1888-1889
5. Baumgartner JD, Glauser MP, Burgo-Black AL, et al. Severe cytomegalovirus infection in multiply transfused, splenectomized, trauma patients. Lancet 1982;2:63-66
6. Langenhuijsen MMAC, van Toorn DW. Splenectomy and the severity of cytomegalovirus infection. Lancet 1982;2:820
7. Blajchman MA. The clinical benefits of the leukoreduction of blood products. J Trauma 2006;60(6 suppl):S83-90
8. Han XY, Lin P, Amin HM, et al. Post-splenectomy cytomegaloviral mononucleosis: marked lymphocytosis, TCR-gamma gene rearrangements, and impaired IgM response. Am J Clin Pathol 2005;123:612-617 (Pubitemid 40418557)
9. Alliot C, Beets C, Besson M, et al. Spontaneous splenic rupture associated with CMV infection: report of a case and review. Scan J Infect Dis 2001;33:875-877 (Pubitemid 33069536)
10. Kangro HO, Griffiths PD, Huber TJ, et al. Specific IgM class antibody production following infection with cytomegalovirus. J Med Virol 1982;10:203-212 (Pubitemid 13211393)
11. Han XY, Anderlini P, Tarrand J. Diagnosis and monitoring of primary cytomegalovirus infection by antigenemia test in stem cell donor. Bone Marrow Transplant 2002;30:411 (Pubitemid 35203517)
12. Molrine DC, Siber GR, Samra Y, et al. Normal IgG and impaired IgM responses to polysaccharide vaccines in asplenic patients. J Infect Dis 1999;179:513-517 (Pubitemid 29086659)
13. Carsetti R, Pantosti A, Quinti I. Impairment of the antipolysaccharide response in splenectomized patients is due to the lack of immunoglobulin M memory B cells. J Infect Dis 2006;193:1189-1190
14. Weller S, Braun MC, Tan BK, et al. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004;104:3647-3654 (Pubitemid 39564441)
15. Kruetzmann S, Rosado MM, Weber H, et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infection are generated in the spleen. J Exp Med 2003;197:939-945 (Pubitemid 36437871)
16. Kano Y, Shiohara T. Current understanding of cytomegalovirus infection in immunocompetent individuals. J Dermatol Sci 2000;22:196-204 (Pubitemid 30068664)
17. Nicholson VA, Whimbey E, Champlin R, et al. Comparison of cytomegalovirus antigenemia and shell vial culture in allogeneic marrow transplantation recipients receiving ganciclovir prophylaxis. Bone Marrow Transplant 1997;19:37-41 (Pubitemid 27056862)
18. Han XY. Epidemiologic analysis of reactivated cytomegalovirus antigenemia in patients with cancer. J Clin Microbiol 2007;45:1126-1132
19. Lesprit P, Scieux C, Lemann M, et al. Use of cytomegalovirus (CMV) antigenemia assay for the rapid diagnosis of primary CMV infection in hospitalized adults. Clin Infect Dis 1998;26:646-650 (Pubitemid 28155014)
20. Assy N, Gefen H, Schlesinger S, et al. Reactivation versus primary CMV infection after splenectomy in immunocompetent patients. Dig Dis Sci 2007;52:3477-3480 (Pubitemid 350077175)
21. Vega F, Medeiros LJ, Jones D, et al. A novel four-color PCR assay to assess T-cell receptor gamma gene rearrangements in lymphoproliferative lesions. Am J Clin Pathol 2001;116:17-24 (Pubitemid 32601122)
22. Mathew P, Hudnall SD, Elghetany MT, et al. T-gamma gene rearrangement and CMV mononucleosis. Am J Haematol 2001;66:64-66 (Pubitemid 32006328)
23. Delobel P, Godel A, Thebault S, et al. Transient clonal expansion of T-large granular lymphocytes during primary cytomegalovirus infection. J Infect 2006;53:e65-7 (Pubitemid 44028667)
24. Strickler JG, Movahed LA, Gajl-Peczalska KJ, et al. Oligoclonal T cell receptor gene rearrangements in blood lymphocytes of patients with acute Epstein-Barr virus-induced infectious mononucleosis. J Clin Invest 1990;86:1358-1363
25. van Stijn A, Rowshani AT, Yong SL, et al. Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8 T cells. J Immunol 2008;180:4550-4560
26. Venturi V, Chin HY, Asher TE, et al. TCR beta-chain sharing in human CD8 T cell responses to cytomegalovirus and EBV. J Immunol 2008;181:7853-7862
27. Sylwester AW, Mitchell BL, Edgar JB, et al. Broadly targeted human cytomegalovirus-specific CD4 and CD8 T cells dominate the memory compartments of exposed subjects. J Exp Med 2005;202:673-685
28. Racine R, Winslow GM. IgM in microbial infections: taken for granted? Immunol Lett 2009;125:79-85