The inner foreskin of healthy males at risk of HIV infection harbors epithelial CD4+ CCR5+ cells and has features of an inflamed epidermal barrier

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Lemos, Maria P ^a   Lama, Javier R ^b   Karuna, Shelly T ^a   Fong, Youyi ^a   Montano, Silvia M ^c   Ganoza, Carmela ^b   Gottardo, Raphael ^a   Sanchez, Jorge ^b   McElrath, M Juliana ^a,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b ASOCIACIÓN CIVIL IMPACTA SALUD Y EDUCACIÓN   (Peru)

^c California   (Peru)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CCR5; CLAUDIN 1; CLAUDIN 4; FIBRONECTIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; OCCLUDIN; RANTES; TIGHT JUNCTION PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CCR5 PROTEIN, HUMAN; CD4 ANTIGEN; CLDN1 PROTEIN, HUMAN; CLDN4 PROTEIN, HUMAN; CXCL10 PROTEIN, HUMAN; CYTOKINE;

ADULT; ARTICLE; CCR5+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL DENSITY; CELL METABOLISM; CELL TRANSPORT; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EPIDERMIS; HIGH RISK PATIENT; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOPATHOGENESIS; INFECTION RISK; INFLAMMATION; INNER FORESKIN; KERATINOCYTE; LABORATORY DIAGNOSIS; LYMPHOCYTE COUNT; MALE; MASTURBATION; MEN WHO HAVE SEX WITH MEN; OUTER FORESKIN; PARAKERATOSIS; PERMEABILITY BARRIER; PERUVIAN; POLARIZATION; PREPUCE; PROTEIN METABOLISM; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASE; STRATUM CORNEUM; STRATUM GRANULOSUM; STRATUM SPINOSUM; SUPRABASAL TIGHT JUNCTION; T LYMPHOCYTE; TIGHT JUNCTION; TISSUE DIFFERENTIATION; WILCOXON SIGNED RANKS TEST; CELL CULTURE; CIRCUMCISION; CYTOLOGY; EPITHELIUM CELL; FEMALE; MALE HOMOSEXUALITY; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENDER;

ADULT; ANTIGENS, CD4; CELLS, CULTURED; CHEMOKINE CCL5; CHEMOKINE CXCL10; CIRCUMCISION, MALE; CLAUDIN-1; CLAUDIN-4; CYTOKINES; EPIDERMIS; EPITHELIAL CELLS; FEMALE; FORESKIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HIV INFECTIONS; HOMOSEXUALITY, MALE; HUMANS; MALE; OCCLUDIN; RECEPTORS, CCR5; TRANSGENDERED PERSONS;

EID: 84907494055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108954     Document Type: Article

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