Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 39, 2014, Pages 9458-9462

  Tomás Navarro, María ^a   Vallejo, Fernando ^a   Borrego, Francisco ^b   Tomás Barberán, Francisco A ^a,c  

^a RESEARCH GROUP ON QUALITY   (Spain)

^b Ferrer HealthTech ^*  (Spain)

^c CATHOLIC UNIVERSITY OF MURCIA   (Spain)

Author keywords

absorption; hesperetin; hesperidin; UPLC triple quadrupole; volunteers stratification

Indexed keywords

HESPERETIN; HESPERIDIN; MICRONIZATIONS; TRIPLE QUADRUPOLE;

ABSORPTION;

HESPERETIN; HESPERIDIN;

ADULT; ANALYSIS; BEVERAGE; BIOAVAILABILITY; CHEMISTRY; DRUG FORMULATION; EVALUATION STUDY; HUMAN; MALE; MIDDLE AGED; PARTICLE SIZE; PROCEDURES; SWEET ORANGE;

ADULT; BEVERAGES; BIOLOGICAL AVAILABILITY; CITRUS SINENSIS; DRUG COMPOUNDING; HESPERIDIN; HUMANS; MALE; MIDDLE AGED; PARTICLE SIZE;

EID: 84907493868     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf502933v     Document Type: Article

References (16)

1. Rizza, S.; Muniyappa, R.; Iantorno, M.; Kim, J.; Chen, H.; Pullikotil, P.; Senese, N.; Tesauro, M.; Lauro, D.; Cardillo, C.; Quon, M. J. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome J. Clin. Endocrinol. Metab. 2011, 96, E782-E792
2. Milenkovic, D.; Deval, C.; Dubray, C.; Mazur, A.; Morand, C. Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study. PLoS One 2011, 6 (11), e26669.
3. Morand, C.; Dubray, C.; Milenkovic, D.; Lioger, D.; Martin, J. F.; Scalbert, A.; Mazur, A. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers Am. J. Clin. Nutr. 2011, 93, 73-80
4. Chanet, A.; Milenkovic, D.; Deval, C. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice J. Nutr. Biochem. 2012, 23, 469-477
5. Chanet, A.; Milenkovic, D.; Manach, C.; Mazur, A.; Morand, C. Citrus flavanones: what is their role in cardiovascular protection? J. Agric. Food Chem. 2012, 60, 8809-8822
6. Tomás-Navarro, M.; Vallejo, F.; Sentandreu, E.; Navarro, J. L.; Tomás-Barberán, F. A. Volunteer stratification is more relevant than technological treatment in orange juice bioavailability J. Agric. Food Chem. 2014, 62, 24-27
7. Ma, Q.; Sun, H.; Che, E.; Zheng, X.; Jiang, T.; Sun, C.; Wang, S. Uniform nano-sized valsartan for dissolution and bioavailability enhancement: influence of particle size and crystalline state Int. J. Pharm. 2013, 441, 75-81
8. Da Silva, F.; Rodrigues da Fonseca, C.; Matias de Alencar, S.; Thomazini, M.; Balieiro, J. C.; Pittia, P.; Favaro-Trindade, C. S. Assessment of production efficiency, physicochemical properties and storage stability of spray-dried propolis, a natural food additive, using gum Arabic and OSA starch-based carrier systems Food Bioprod. Process. 2013, 91, 28-36
9. Tommasini, S.; Calabró, M. L.; Stancanelli, R.; Donato, P.; Costa, C.; Catania, S.; Villari, V.; Ficarra, P.; Ficarra, R. The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-β-cyclodextrin J. Pharm. Biomed. Anal. 2005, 39, 572-580
10. 4-induced acute liver failure Pharm. Res. 2009, 26, 893-901
11. Uchiyama, H.; Tozuka, Y.; Imono, M.; Takeuchi, H. Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with α-glucosyl hesperidin Int. J. Pharm. 2010, 392, 101-106
12. Mullen, W.; Archeveque, M. A.; Edwards, C. A.; Matsumoto, H.; Crozier, A. Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt J. Agric. Food Chem. 2008, 56, 11157-11164
13. Vallejo, F.; Larrosa, M.; Escudero, E.; Zafrilla, M. P.; Cerdá, B.; Boza, J.; García-Conesa, M. T.; Espin, J. C.; Tomás-Barberán, F. A. Concentration and solubility of flavanones in orange b everages affect their bioavailability in humans J. Agric. Food Chem. 2010, 58, 6516-6524
14. Tomás-Barberán, F. A.; Mine, Y. A key to understanding the effects of food bioactives in health. Gut microbiota J. Agric. Food Chem. 2013, 61, 9755-9757
15. Liu, L.; Chen, J. Solubility of hesperetin in various solvents from (288.2 to 323.2) K J. Chem. Eng. Data 2008, 53, 1649-1650
16. Mauludin, R.; Müller, R. H. Physicochemical properties of hesperidin nanocrystal Int. J. Pharm. Pharm. Sci. 2013, 5, 954-960