Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

Blood

Volumn 121, Issue 4, 2013, Pages 614-623

  Gérart, Stéphane ^a,b   Sibéril, Sophie ^a,b   Martin, Emmanuel ^a   Lenoir, Christelle ^a   Aguilar, Claire ^a,b   Picard, Capucine ^a,b,c   Lantz, Olivier ^c   Fischer, Alain ^a,b   Latour, Sylvain ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PLZF; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INVARIANT NATURAL KILLER T CELL; MUCOSAL ASSOCIATED INVARIANT CELL; NATURAL KILLER T CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 84873035362     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-09-456095     Document Type: Article

References (36)

1. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007;25:297-336.
2. Gapin L. iNKT cell autoreactivity: what is "self" and how is it recognized? Nat Rev Immunol. 2010;10(4):272-277.
3. Das R, Sant'Angelo DB, Nichols KE. Transcrip-tional control of invariant NKT cell development. Immunol Rev. 2010;238(1):195-215.
4. Treiner E, Duban L, Bahram S, et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature. 2003;422(6928): 164-169.
5. Dusseaux M, Martin E, Serriari N, et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood. 2011;117(4): 1250-1259.
6. Martin E, Treiner E, Duban L, et al. Stepwise development of MAIT cells in mouse and human. PLoS Biol. 2009;7(3):e54.
7. Le Bourhis L, Guerri L, Dusseaux M, Martin E, Soudais C, Lantz O. Mucosal-associated invariant T cells: unconventional development and function. Trends Immunol. 2011;32(5):212-218.
8. Gapin L. Where do MAIT cells fit in the family of unconventional T cells? PLoS Biol. 2009;7(3): e70.
9. Berzins SP, Smyth MJ, Baxter AG. Presumed guilty: natural killer T cell defects and human disease. Nat Rev Immunol. 2011;11(2):131-142.
10. Rigaud S, Fondaneche MC, Lambert N, et al. XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. Nature. 2006; 444(7115):110-114.
11. Pasquier B, Yin L, Fondaneche MC, et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphopro-liferative syndrome gene product. J Exp Med. 2005;201(5):695-701.
12. Locci M, Draghici E, Marangoni F, et al. The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function. J Exp Med. 2009;206(4):735-742.
13. Nichols KE, Hom J, Gong SY, et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med. 2005;11(3):340-345.
14. Zeissig S, Blumberg RS. Primary immunodeficiency associated with defects in CD1 and CD1-restricted T cells. Ann N Y Acad Sci. 2012;1250: 14-24.
15. Pachlopnik Schmid J, Canioni D, Moshous D, et al. Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency). Blood. 2011;117(5): 1522-1529.
16. Coffey AJ, Brooksbank RA, Brandau O, et al. Host response to EBV infection in X-linked lym-phoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 1998; 20(2):129-135.
17. Sayos J, Wu C, Morra M, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395(6701):462-469.
18. Nichols KE, Harkin DP, Levitz S, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998;95(23):13765-13770.
19. Griewank K, Borowski C, Rietdijk S, et al. Homo-typic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity. 2007;27(5):751-762.
20. Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 2006; 7(10):988-994.
21. Galban S, Duckett CS. XIAP as a ubiquitin ligase in cellular signaling. Cell Death Differ. 2010;17(1): 54-60.
22. Damgaard RB, Nachbur U, Yabal M, et al. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012;46:1-13.
23. Mateo V, Menager M, de Saint-Basile G, et al. Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes. Blood. 2007; 110(13):4285-4292.
24. Sohn EJ, Li H, Reidy K, Beers LF, Christensen BL, Lee SB. EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo. Cancer Res. 2010;70(3):1154-1163.
25. Bouillet P, O'Reilly LA. CD95, BIM and T cell ho-meostasis. Nat Rev Immunol. 2009;9(7):514-519.
26. Brenner D, Mak TW. Mitochondrial cell death effectors. Curr Opin Cell Biol. 2009;21(6):871-877.
27. Kovalovsky D, Uche OU, Eladad S, et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol. 2008;9(9): 1055-1064.
28. Savage AK, Constantinides MG, Han J, et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity. 2008; 29(3):391-403.
29. Yeyati PL, Shaknovich R, Boterashvili S, et al. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene. 1999;18(4):925-934.
30. Shaknovich R, Yeyati PL, Ivins S, et al. The pro-myelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apopto-sis. Mol Cell Biol. 1998;18(9):5533-5545.
31. Cheung M, Pei J, Pei Y, Jhanwar SC, Pass HI, Testa Jr. The promyelocytic leukemia zinc-finger gene, PLZF, is frequently down-regulated in malignant mesothelioma cells and contributes to cell survival. Oncogene. 2010;29(11):1633-1640.
32. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell. 2002;9(3): 459-470.
33. van Gisbergen KP, Kragten NA, Hertoghs KM, et al. Mouse Hobit is a homolog of the transcrip-tional repressor Blimp-1 that regulates NKT cell effector differentiation. Nat Immunol. 2012;13(9): 864-871.
34. Marsh RA, Madden L, Kitchen BJ, et al. XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lym-phoproliferative disease. Blood. 2010;116(7): 1079-1082.
35. Zeissig S, Murata K, Sweet L, et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012;18(7):1060-1068.
36. zur Stadt U, Rohr J, Seifert W, et al. Familial he-mophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet. 2009; 85(4):482-492.