Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development

Diabetes

Volumn 63, Issue 10, 2014, Pages 3470-3482

  Radichev, Ilian A ^a,b   Maneva Radicheva, Lilia V ^a,b   Amatya, Christina ^a,b   Parker, Camille ^a,b   Ellefson, Jacob ^a,b   Wasserfall, Clive ^c   Atkinson, Mark ^c   Burn, Paul ^a,b   Savinov, Alexei Y ^a,b  

^a SANFORD RESEARCH   (United States)

^b UNIVERSITY OF SOUTH DAKOTA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPROTEINASE; NARDILYSIN; UNCLASSIFIED DRUG; V SET DOMAIN CONTAINING T CELL ACTIVATION INHIBITOR 1; BIOLOGICAL MARKER; VTCN1 PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; DENDRITIC CELL; DIABETIC PATIENT; DIABETOGENESIS; DISEASE COURSE; DISEASE PREDISPOSITION; FEMALE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN SECRETION; T LYMPHOCYTE; ADOLESCENT; ANIMAL; CHILD; METABOLISM; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL MARKERS; CHILD; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED NOD; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1; YOUNG ADULT;

EID: 84907485625     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0213     Document Type: Article

References (39)

1. La Torre D, Lernmark A. Immunology of beta-cell destruction. Adv Exp Med Biol 2010;654:537-583
2. Haskins K, Cooke A. CD4 T cells and their antigens In the pathogenesis of autoimmune diabetes. Curr Opin Immunol 2011;23:739-745
3. Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW. Autoreactive T cells In healthy Individuals. J Immunol 2004;172:5967-5972
4. Fink PJ, Hendricks DW. Post-thymic maturation: Young T cells assert their individuality. Nat Rev Immunol 2011;11:544-549
5. Bach JF, Chatenoud L. Tolerance to islet autoantigens In type 1 diabetes. Annu Rev Immunol 2001;19:131-161
6. Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 2008;224:166-182
7. Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999;5: 1365-1369
8. Sica GL, Choi IH, Zhu G, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003;18:849-861
9. Wang L, Rubinstein R, Lines JL, et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp Med 2011;208:577-592
10. Prasad DV, Richards S, Mai XM, Dong C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 2003;18:863-873
11. Wang X, Hao J, Metzger DL, et al. B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation. PLoS One 2012;7:e28232
12. Zang X, Loke P, Kim J, Murphy K, Waltz R, Allison JP. B7x: a widely expressed B7 family member that Inhibits T cell activation. Proc Natl Acad Sci U S A 2003;100:10388-10392
13. Azuma T, Zhu G, Xu H, et al. Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: A mouse model informed by clinical data. PLoS Med 2009;6:e1000166
14. Wei J, Loke P, Zang X, Allison JP. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med 2011; 208:1683-1694
15. Ou D, Wang X, Metzger DL, et al. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway. Cell Transplant 2006;15:399-410
16. Wang X, Hao J, Metzger DL, et al. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes 2011; 60:3246-3255
17. Wang X, Hao J, Metzger DL, et al. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation 2009;87:482-490
18. Lee JS, Scandiuzzi L, Ray A, et al. B7x in the periphery abrogates pancreasspecific damage mediated by self-reactive CD8 T cells. J Immunol 2012;189: 4165-4174
19. Varanasi V, Avanesyan L, Schumann DM, Chervonsky AV. Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells. Diabetes 2012;61 : 2862-2870
20. Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages. Curr Protoc Immunol 2008;Chapter 14:Unit 14.1
21. Walker EB, Akporiaye ET, Warner NL, Stewart CC. Characterization of subsets of bone marrow-derived macrophages by flow cytometry analysis. J Leukoc Biol 1985;37:121-136
22. Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994;171:131-137
23. Radichev IA, Remade AG, Shiryaev SA, et al. Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. J Biol Chem 2010;285:16076-16086
24. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25:402-408
25. Radichev I, Kwon SW, Zhao Y, DePamphilis ML, Vassilev A. Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex. J Biol Chem 2006;281 : 23264-23273
26. Cao Q, Wang Y, Zheng D, et al. IL-10/TGF-beta-modifled macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol 2010;21:933-942
27. Kryczek I, Wei S, Zou L, et al. Cutting edge: Induction of B7-H4 on APCs through IL-10: Novel suppressive mode for regulatory T cells. J Immunol 2006; 177:40-44
28. Yamaura K, Watanabe T, Boenisch O, et al. In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses. Am J Transplant 2010;10: 2355-2362
29. Hospital V, Chesneau V, Balogh A, et al. N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface. Biochem J 2000;349:587-597
30. Chesneau V, Pierotti AR, Barré N, Créminon C, Tougard C, Cohen P. Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues. J Biol Chem 1994;269: 2056-2061
31. Cambuli VM, Incani M, Cossu E, et al. Prevalence of type 1 diabetes autoantibodies (GADA, IA2, and IAA) in overweight and obese children. Diabetes Care 2010;33:820-822
32. Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol 2012;13:361-368
33. Katschke KJ Jr, Helmy KY, Steffek M, et al. A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med 2007;204:1319-1325
34. Keir ME, Liang SC, Guleria I, et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006;203:883-895
35. Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motifcarrying immunoreceptor. Immunity 1999;11:141-151
36. Salama AD, Chitnis T, Imitola J, et al. Critical role of the programmed death1 1 pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 2003;198:71-78
37. Gaglia JL, Guimaraes AR, Harisinghani M, et al. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest 2011; 121:442-445
38. Kessler JH, Khan S, Seifert U, et al. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol 2011;12: 45-53
39. Teixeira VH, Olaso R, Martin-Magniette ML, et al. Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients. PLoS One 2009;4:e6803