메뉴 건너뛰기




Volumn 9, Issue 9, 2014, Pages

The Huntington's disease-related cardiomyopathy prevents a hypertrophic response in the R6/2 mouse model

Author keywords

[No Author keywords available]

Indexed keywords

ISOPRENALINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; COLLAGEN TYPE 6; HISTONE DEACETYLASE;

EID: 84907484531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108961     Document Type: Article
Times cited : (24)

References (49)
  • 2
    • 0027432418 scopus 로고
    • Widespread expression of the human and rat huntington's disease gene in brain and nonneural tissues
    • Strong TV, Tagle DA, Valdes JM, Elmer LW, Boehm K, et al. (1993) Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nat Genet 5: 259-265.
    • (1993) Nat Genet , vol.5 , pp. 259-265
    • Strong, T.V.1    Tagle, D.A.2    Valdes, J.M.3    Elmer, L.W.4    Boehm, K.5
  • 3
    • 69949102831 scopus 로고    scopus 로고
    • Huntington's disease: The current state of research with peripheral tissues
    • Sassone J, Colciago C, Cislaghi G, Silani V, Ciammola A (2009) Huntington's disease: the current state of research with peripheral tissues. Exp Neurol 219: 385-397.
    • (2009) Exp Neurol , vol.219 , pp. 385-397
    • Sassone, J.1    Colciago, C.2    Cislaghi, G.3    Silani, V.4    Ciammola, A.5
  • 4
    • 67650095269 scopus 로고    scopus 로고
    • Beyond the brain: Widespread pathology in huntington's disease
    • van der Burg JM, Bjorkqvist M, Brundin P (2009) Beyond the brain: widespread pathology in Huntington's disease. Lancet Neurol 8: 765-774.
    • (2009) Lancet Neurol , vol.8 , pp. 765-774
    • Van Der Burg, J.M.1    Bjorkqvist, M.2    Brundin, P.3
  • 5
    • 0027484673 scopus 로고
    • Huntington's disease gene (IT15) is widely expressed in human and rat tissues
    • Li SH, Schilling G, Young WS 3rd, Li XJ, Margolis RL, et al. (1993) Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11: 985-993.
    • (1993) Neuron , vol.11 , pp. 985-993
    • Li, S.H.1    Schilling, G.2    Young, W.S.3    Li, X.J.4    Margolis, R.L.5
  • 6
    • 33744921670 scopus 로고    scopus 로고
    • Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein
    • Li W, Serpell LC, Carter WJ, Rubinsztein DC, Huntington JA (2006) Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem 281: 15916-15922.
    • (2006) J Biol Chem , vol.281 , pp. 15916-15922
    • Li, W.1    Serpell, L.C.2    Carter, W.J.3    Rubinsztein, D.C.4    Huntington, J.A.5
  • 7
    • 0041656292 scopus 로고    scopus 로고
    • The hunt for huntingtin function: Interaction partners tell many different stories
    • Harjes P, Wanker EE (2003) The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem Sci 28: 425-433.
    • (2003) Trends Biochem Sci , vol.28 , pp. 425-433
    • Harjes, P.1    Wanker, E.E.2
  • 8
    • 0027078587 scopus 로고
    • Causes of death in patients with huntington's disease and in unaffected first degree relatives
    • Sorensen SA, Fenger K (1992) Causes of death in patients with Huntington's disease and in unaffected first degree relatives. J Med Genet 29: 911-914.
    • (1992) J Med Genet , vol.29 , pp. 911-914
    • Sorensen, S.A.1    Fenger, K.2
  • 9
    • 0020487253 scopus 로고
    • Causes of death in huntington's disease
    • Chiu E, Alexander L (1982) Causes of death in Huntington's disease. Med J Aust 1: 153.
    • (1982) Med J Aust , vol.1 , pp. 153
    • Chiu, E.1    Alexander, L.2
  • 11
    • 44449104300 scopus 로고    scopus 로고
    • Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure
    • Pattison JS, Sanbe A, Maloyan A, Osinska H, Klevitsky R, et al. (2008) Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation 117: 2743-2751.
    • (2008) Circulation , vol.117 , pp. 2743-2751
    • Pattison, J.S.1    Sanbe, A.2    Maloyan, A.3    Osinska, H.4    Klevitsky, R.5
  • 12
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, et al. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87: 493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1    Sathasivam, K.2    Seller, M.3    Cozens, B.4    Harper, A.5
  • 14
    • 33847684865 scopus 로고    scopus 로고
    • The hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes
    • Woodman B, Butler R, Landles C, Lupton MK, Tse J, et al. (2007) The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes. Brain Res Bull 72: 83-97.
    • (2007) Brain Res Bull , vol.72 , pp. 83-97
    • Woodman, B.1    Butler, R.2    Landles, C.3    Lupton, M.K.4    Tse, J.5
  • 15
    • 84944718721 scopus 로고    scopus 로고
    • Dysfunction of the CNS-heart axis in mouse models of huntington's disease
    • Mielcarek M, Inuabasi L, Bondulich MK, Muller T, Osborne GF, et al. (2014) Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease. PLoS Genet 10: e1004550.
    • (2014) PLoS Genet , vol.10 , pp. e1004550
    • Mielcarek, M.1    Inuabasi, L.2    Bondulich, M.K.3    Muller, T.4    Osborne, G.F.5
  • 17
    • 84869785257 scopus 로고    scopus 로고
    • Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of huntington's disease
    • Kiriazis H, Jennings NL, Davern P, Lambert G, Su Y, et al. (2012) Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease. J Physiol 590: 5845-5860.
    • (2012) J Physiol , vol.590 , pp. 5845-5860
    • Kiriazis, H.1    Jennings, N.L.2    Davern, P.3    Lambert, G.4    Su, Y.5
  • 18
    • 84892738799 scopus 로고    scopus 로고
    • Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the drosophila heart
    • Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, et al. (2013) Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. PLoS Genet 9: e1004024.
    • (2013) PLoS Genet , vol.9 , pp. e1004024
    • Melkani, G.C.1    Trujillo, A.S.2    Ramos, R.3    Bodmer, R.4    Bernstein, S.I.5
  • 19
    • 0029149020 scopus 로고
    • Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart
    • Boluyt MO, Long X, Eschenhagen T, Mende U, Schmitz W, et al. (1995) Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart. Am J Physiol 269: H638-647.
    • (1995) Am J Physiol , vol.269 , pp. H638-647
    • Boluyt, M.O.1    Long, X.2    Eschenhagen, T.3    Mende, U.4    Schmitz, W.5
  • 20
    • 0031912189 scopus 로고    scopus 로고
    • Development of heart failure following isoproterenol administration in the rat: Role of the renin-angiotensin system
    • Grimm D, Elsner D, Schunkert H, Pfeifer M, Griese D, et al. (1998) Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. Cardiovasc Res 37: 91-100.
    • (1998) Cardiovasc Res , vol.37 , pp. 91-100
    • Grimm, D.1    Elsner, D.2    Schunkert, H.3    Pfeifer, M.4    Griese, D.5
  • 21
    • 33847694326 scopus 로고    scopus 로고
    • Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and beta-adrenergic desensitization
    • Jin YT, Hasebe N, Matsusaka T, Natori S, Ohta T, et al. (2007) Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and beta-adrenergic desensitization. Am J Physiol Heart Circ Physiol 292: H1593-1599.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. H1593-1599
    • Jin, Y.T.1    Hasebe, N.2    Matsusaka, T.3    Natori, S.4    Ohta, T.5
  • 22
    • 3142735025 scopus 로고    scopus 로고
    • Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes
    • Chen HH, Mullett SJ, Stewart AF (2004) Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. J Biol Chem 279: 30800-30806.
    • (2004) J Biol Chem , vol.279 , pp. 30800-30806
    • Chen, H.H.1    Mullett, S.J.2    Stewart, A.F.3
  • 23
    • 58749098559 scopus 로고    scopus 로고
    • VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development
    • Mielcarek M, Piotrowska I, Schneider A, Gunther S, Braun T (2009) VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development. Gene Expr Patterns 9: 129-137.
    • (2009) Gene Expr Patterns , vol.9 , pp. 129-137
    • Mielcarek, M.1    Piotrowska, I.2    Schneider, A.3    Gunther, S.4    Braun, T.5
  • 24
    • 1342306306 scopus 로고    scopus 로고
    • VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation
    • Gunther S, Mielcarek M, Kruger M, Braun T (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res 32: 791-802.
    • (2004) Nucleic Acids Res , vol.32 , pp. 791-802
    • Gunther, S.1    Mielcarek, M.2    Kruger, M.3    Braun, T.4
  • 25
    • 1342342827 scopus 로고    scopus 로고
    • VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage
    • Mielcarek M, Gunther S, Kruger M, Braun T (2002) VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Mech Dev 119 Suppl 1: S269-274.
    • (2002) Mech Dev , vol.119 , pp. S269-274
    • Mielcarek, M.1    Gunther, S.2    Kruger, M.3    Braun, T.4
  • 26
    • 56549119132 scopus 로고    scopus 로고
    • Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of huntington's disease
    • Benn CL, Fox H, Bates GP (2008) Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease. Mol Neurodegener 3: 17.
    • (2008) Mol Neurodegener , vol.3 , pp. 17
    • Benn, C.L.1    Fox, H.2    Bates, G.P.3
  • 27
    • 0032514177 scopus 로고    scopus 로고
    • Transcription factor RTEF-1 mediates alpha1-adrenergic reactivation of the fetal gene program in cardiac myocytes
    • Stewart AF, Suzow J, Kubota T, Ueyama T, Chen HH (1998) Transcription factor RTEF-1 mediates alpha1-adrenergic reactivation of the fetal gene program in cardiac myocytes. Circ Res 83: 43-49.
    • (1998) Circ Res , vol.83 , pp. 43-49
    • Stewart, A.F.1    Suzow, J.2    Kubota, T.3    Ueyama, T.4    Chen, H.H.5
  • 28
    • 77951583581 scopus 로고    scopus 로고
    • TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction
    • Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, et al. (2010) TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem 285: 13721-13735.
    • (2010) J Biol Chem , vol.285 , pp. 13721-13735
    • Tsika, R.W.1    Ma, L.2    Kehat, I.3    Schramm, C.4    Simmer, G.5
  • 29
    • 0038298908 scopus 로고    scopus 로고
    • Basal and alpha1-adrenergic-induced activity of minimal rat betaMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites
    • McLean BG, Lee KS, Simpson PC, Farrance IK (2003) Basal and alpha1-adrenergic-induced activity of minimal rat betaMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites. J Mol Cell Cardiol 35: 461-471.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 461-471
    • McLean, B.G.1    Lee, K.S.2    Simpson, P.C.3    Farrance, I.K.4
  • 30
    • 77952880971 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Keeping momentum for neuromuscular and cardiovascular diseases treatment
    • Colussi C, Illi B, Rosati J, Spallotta F, Farsetti A, et al. (2010) Histone deacetylase inhibitors: keeping momentum for neuromuscular and cardiovascular diseases treatment. Pharmacol Res 62: 3-10.
    • (2010) Pharmacol Res , vol.62 , pp. 3-10
    • Colussi, C.1    Illi, B.2    Rosati, J.3    Spallotta, F.4    Farsetti, A.5
  • 31
    • 84855875719 scopus 로고    scopus 로고
    • Therapeutic potential for HDAC inhibitors in the heart
    • McKinsey TA (2012) Therapeutic potential for HDAC inhibitors in the heart. Annu Rev Pharmacol Toxicol 52: 303-319.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 303-319
    • McKinsey, T.A.1
  • 32
    • 67650418364 scopus 로고    scopus 로고
    • Targeting histone deacetylases for heart failure
    • Bush EW, McKinsey TA (2009) Targeting histone deacetylases for heart failure. Expert Opin Ther Targets 13: 767-784.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 767-784
    • Bush, E.W.1    McKinsey, T.A.2
  • 33
    • 0041530268 scopus 로고    scopus 로고
    • Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors
    • Antos CL, McKinsey TA, Dreitz M, Hollingsworth LM, Zhang CL, et al. (2003) Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. J Biol Chem 278: 28930-28937.
    • (2003) J Biol Chem , vol.278 , pp. 28930-28937
    • Antos, C.L.1    McKinsey, T.A.2    Dreitz, M.3    Hollingsworth, L.M.4    Zhang, C.L.5
  • 34
    • 85047694248 scopus 로고    scopus 로고
    • Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein hop
    • Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, et al. (2003) Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest 112: 863-871.
    • (2003) J Clin Invest , vol.112 , pp. 863-871
    • Kook, H.1    Lepore, J.J.2    Gitler, A.D.3    Lu, M.M.4    Wing-Man Yung, W.5
  • 35
    • 33644861578 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding
    • Kee HJ, Sohn IS, Nam KI, Park JE, Qian YR, et al. (2006) Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation 113: 51-59.
    • (2006) Circulation , vol.113 , pp. 51-59
    • Kee, H.J.1    Sohn, I.S.2    Nam, K.I.3    Park, J.E.4    Qian, Y.R.5
  • 36
    • 44349184388 scopus 로고    scopus 로고
    • HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity
    • Gupta MP, Samant SA, Smith SH, Shroff SG (2008) HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. J Biol Chem 283: 10135-10146.
    • (2008) J Biol Chem , vol.283 , pp. 10135-10146
    • Gupta, M.P.1    Samant, S.A.2    Smith, S.H.3    Shroff, S.G.4
  • 37
    • 55849084700 scopus 로고    scopus 로고
    • Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
    • Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, et al. (2008) Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest 118: 3588-3597.
    • (2008) J Clin Invest , vol.118 , pp. 3588-3597
    • Montgomery, R.L.1    Potthoff, M.J.2    Haberland, M.3    Qi, X.4    Matsuzaki, S.5
  • 38
    • 77955984513 scopus 로고    scopus 로고
    • HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats
    • Cardinale JP, Sriramula S, Pariaut R, Guggilam A, Mariappan N, et al. (2010) HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. Hypertension 56: 437-444.
    • (2010) Hypertension , vol.56 , pp. 437-444
    • Cardinale, J.P.1    Sriramula, S.2    Pariaut, R.3    Guggilam, A.4    Mariappan, N.5
  • 39
    • 54049090410 scopus 로고    scopus 로고
    • Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice
    • Granger A, Abdullah I, Huebner F, Stout A, Wang T, et al. (2008) Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J 22: 3549-3560.
    • (2008) FASEB J , vol.22 , pp. 3549-3560
    • Granger, A.1    Abdullah, I.2    Huebner, F.3    Stout, A.4    Wang, T.5
  • 40
    • 34547886153 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase on ventricular remodeling in infarcted rats
    • Lee TM, Lin MS, Chang NC (2007) Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. Am J Physiol Heart Circ Physiol 293: H968-977.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H968-977
    • Lee, T.M.1    Lin, M.S.2    Chang, N.C.3
  • 41
    • 55549099609 scopus 로고    scopus 로고
    • Transgenic overexpression of hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy
    • Trivedi CM, Lu MM, Wang Q, Epstein JA (2008) Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem 283: 26484-26489.
    • (2008) J Biol Chem , vol.283 , pp. 26484-26489
    • Trivedi, C.M.1    Lu, M.M.2    Wang, Q.3    Epstein, J.A.4
  • 42
    • 4544358659 scopus 로고    scopus 로고
    • Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
    • Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, et al. (2004) Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol 24: 8467-8476.
    • (2004) Mol Cell Biol , vol.24 , pp. 8467-8476
    • Chang, S.1    McKinsey, T.A.2    Zhang, C.L.3    Richardson, J.A.4    Hill, J.A.5
  • 43
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, et al. (2002) Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110: 479-488.
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1    McKinsey, T.A.2    Chang, S.3    Antos, C.L.4    Hill, J.A.5
  • 44
    • 8844247034 scopus 로고    scopus 로고
    • Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
    • Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J (2004) Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 95: 971-980.
    • (2004) Circ Res , vol.95 , pp. 971-980
    • Alcendor, R.R.1    Kirshenbaum, L.A.2    Imai, S.3    Vatner, S.F.4    Sadoshima, J.5
  • 45
    • 0141678246 scopus 로고    scopus 로고
    • Standardization and statistical approaches to therapeutic trials in the R6/2 mouse
    • Hockly E, Woodman B, Mahal A, Lewis CM, Bates G (2003) Standardization and statistical approaches to therapeutic trials in the R6/2 mouse. Brain Res Bull 61: 469-479.
    • (2003) Brain Res Bull , vol.61 , pp. 469-479
    • Hockly, E.1    Woodman, B.2    Mahal, A.3    Lewis, C.M.4    Bates, G.5
  • 46
    • 77649297870 scopus 로고    scopus 로고
    • Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of huntington's disease
    • Sathasivam K, Lane A, Legleiter J, Warley A, Woodman B, et al. (2010) Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease. Hum Mol Genet 19: 65-78.
    • (2010) Hum Mol Genet , vol.19 , pp. 65-78
    • Sathasivam, K.1    Lane, A.2    Legleiter, J.3    Warley, A.4    Woodman, B.5
  • 47
    • 84889000595 scopus 로고    scopus 로고
    • HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo
    • Mielcarek M, Seredenina T, Stokes MP, Osborne GF, Landles C, et al. (2013) HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo. PLoS One 8: e80849.
    • (2013) PLoS One , vol.8 , pp. e80849
    • Mielcarek, M.1    Seredenina, T.2    Stokes, M.P.3    Osborne, G.F.4    Landles, C.5
  • 48
    • 84889031644 scopus 로고    scopus 로고
    • HDAC4 reduction: A novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration
    • Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, et al. (2013) HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration. PLoS Biol 11: e1001717.
    • (2013) PLoS Biol , vol.11 , pp. e1001717
    • Mielcarek, M.1    Landles, C.2    Weiss, A.3    Bradaia, A.4    Seredenina, T.5
  • 49
    • 82155182012 scopus 로고    scopus 로고
    • SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of huntington's disease
    • Mielcarek M, Benn CL, Franklin SA, Smith DL, Woodman B, et al. (2011) SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease. PLoS One 6: e27746.
    • (2011) PLoS One , vol.6 , pp. e27746
    • Mielcarek, M.1    Benn, C.L.2    Franklin, S.A.3    Smith, D.L.4    Woodman, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.