-
1
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
DOI 10.1038/nm1160
-
Insinga A, Monestiroli S, Ronzoni S, et al: Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 11: 71-76, 2005. (Pubitemid 40215840)
-
(2005)
Nature Medicine
, vol.11
, Issue.1
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
Altucci, L.7
Nervi, C.8
Minucci, S.9
Pelicci, P.G.10
-
2
-
-
67449127083
-
Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: Mechanisms and potential clinical implications
-
Schrump DS: Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications. Clin Cancer Res 15: 3947-3957, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3947-3957
-
-
Schrump, D.S.1
-
3
-
-
34250326306
-
Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes
-
DOI 10.1101/gr.5540007
-
Rada-Iglesias A, Enroth S, Ameur A, et al: Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes. Genome Res 17: 708-719, 2007. (Pubitemid 46919708)
-
(2007)
Genome Research
, vol.17
, Issue.6
, pp. 708-719
-
-
Rada-Iglesias, A.1
Enroth, S.2
Ameur, A.3
Koch, C.M.4
Clelland, G.K.5
Respuela-Alonso, P.6
Wilcox, S.7
Dovey, O.M.8
Ellis, P.D.9
Langford, C.F.10
Dunham, I.11
Komorowski, J.12
Wadelius, C.13
-
4
-
-
13944274571
-
Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
-
DOI 10.1158/1541-7786.MCR-04-0070
-
Hu J and Colburn NH: Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. Mol Cancer Res 3: 100-109, 2005. (Pubitemid 40271140)
-
(2005)
Molecular Cancer Research
, vol.3
, Issue.2
, pp. 100-109
-
-
Hu, J.1
Colburn, N.H.2
-
5
-
-
1442330508
-
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
-
DOI 10.1073/pnas.0308762101
-
Luo J, Li M, Tang Y, Laszkowska M, Roeder RG and Gu W: Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 101: 2259-2264, 2004. (Pubitemid 38269299)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.8
, pp. 2259-2264
-
-
Luo, J.1
Li, M.2
Tang, Y.3
Laszkowska, M.4
Roeder, R.G.5
Gu, W.6
-
6
-
-
3142720638
-
Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
-
Jin YH, Jeon EJ, Li QL, et al: Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem 279: 29409-29417, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 29409-29417
-
-
Jin, Y.H.1
Jeon, E.J.2
Li, Q.L.3
-
7
-
-
67449138841
-
Epigenetic modifiers: Basic understanding and clinical development
-
Piekarz RL and Bates SE: Epigenetic modifiers: basic understanding and clinical development. Clin Cancer Res 15: 3918-3926, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3918-3926
-
-
Piekarz, R.L.1
Bates, S.E.2
-
8
-
-
79952932076
-
Histone deacetylase inhibitors: Molecular mechanisms of action and clinical trials as anti-cancer drugs
-
Kim HJ and Bae SC: Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res 3: 166-179, 2011.
-
(2011)
Am J Transl Res
, vol.3
, pp. 166-179
-
-
Kim, H.J.1
Bae, S.C.2
-
9
-
-
1242319389
-
Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells
-
DOI 10.1002/ijc.11697
-
Kobayashi H, Tan EM and Fleming SE: Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells. Int J Cancer 109: 207-213, 2004. (Pubitemid 38240922)
-
(2004)
International Journal of Cancer
, vol.109
, Issue.2
, pp. 207-213
-
-
Kobayashi, H.1
Tan, E.M.2
Fleming, S.E.3
-
10
-
-
4544343758
-
Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines
-
Chen YX, Fang JY, Zhu HY, Lu R, Cheng ZH and Qiu DK: Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. World J Gastroenterol 10: 2643-2646, 2004. (Pubitemid 39214494)
-
(2004)
World Journal of Gastroenterology
, vol.10
, Issue.18
, pp. 2643-2646
-
-
Chen, Y.-X.1
Fang, J.-Y.2
Zhu, H.-Y.3
Lu, R.4
Cheng, Z.-H.5
Qiu, D.-K.6
-
11
-
-
2342603414
-
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
-
DOI 10.1016/S1535-6108(04)00114-X, PII S153561080400114X
-
Zhu P, Martin E, Mengwasser J, Schlag P, Janssen KP and Gottlicher M: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 5: 455-463, 2004. (Pubitemid 38610247)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 455-463
-
-
Zhu, P.1
Martin, E.2
Mengwasser, J.3
Schlag, P.4
Janssen, K.-P.5
Gottlicher, M.6
-
12
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
DOI 10.1038/nature03319
-
Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature 434: 843-850, 2005. (Pubitemid 40558990)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
13
-
-
33744791463
-
Wnt signaling: Is the party in the nucleus?
-
DOI 10.1101/gad.1424006
-
Willert K and Jones KA: Wnt signaling: is the party in the nucleus? Genes Dev 20: 1394-1404, 2006. (Pubitemid 43830647)
-
(2006)
Genes and Development
, vol.20
, Issue.11
, pp. 1394-1404
-
-
Willert, K.1
Jones, K.A.2
-
14
-
-
0030949463
-
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
-
DOI 10.1126/science.275.5307.1787
-
Morin PJ, Sparks AB, Korinek V, et al: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790, 1997. (Pubitemid 27136715)
-
(1997)
Science
, vol.275
, Issue.5307
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
Kinzler, K.W.7
-
15
-
-
0030569556
-
Direct inhibition of the expression of cyclin d1 gene by sodium butyrate
-
DOI 10.1006/bbrc.1996.1774
-
Lallemand F, Courilleau D, Sabbah M, Redeuilh G and Mester J: Direct inhibition of the expression of cyclin D1 gene by sodium butyrate. Biochem Biophys Res Commun 229: 163-169, 1996. (Pubitemid 27013725)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.229
, Issue.1
, pp. 163-169
-
-
Lallemand, F.1
Courilleau, D.2
Sabbah, M.3
Redeuilh, G.4
Mester, J.5
-
16
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
DOI 10.1038/86507
-
Kim MS, Kwon HJ, Lee YM, et al: Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 7: 437-443, 2001. (Pubitemid 32298546)
-
(2001)
Nature Medicine
, vol.7
, Issue.4
, pp. 437-443
-
-
Kim, M.S.1
Kwon, H.J.2
Lee, Y.M.3
Baek, J.H.4
Jang, J.-E.5
Lee, S.-W.6
Moon, E.-J.7
Kim, H.-S.8
Lee, S.-K.9
Chung, H.Y.10
Kim, C.W.11
Kim, K.-W.12
-
17
-
-
0036132095
-
Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate
-
Bordonaro M, Lazarova DL, Augenlicht LH and Sartorelli AC: Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. Int J Cancer 97: 42-51, 2002.
-
(2002)
Int J Cancer
, vol.97
, pp. 42-51
-
-
Bordonaro, M.1
Lazarova, D.L.2
Augenlicht, L.H.3
Sartorelli, A.C.4
-
18
-
-
0027170789
-
Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells
-
Heruth DP, Zirnstein GW, Bradley JF and Rothberg PG: Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells. J Biol Chem 268: 20466-20472, 1993. (Pubitemid 23278957)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.27
, pp. 20466-20472
-
-
Heruth, D.P.1
Zirnstein, G.W.2
Bradley, J.F.3
Rothberg, P.G.4
-
19
-
-
0023425498
-
The N-end rule of selective protein turnover: Mechanistic aspects and functional implications
-
Varshavsky A, Bachmair A and Finley D: The N-end rule of selective protein turnover: mechanistic aspects and functional implications. Biochem Soc Trans 15: 815-816, 1987.
-
(1987)
Biochem Soc Trans
, vol.15
, pp. 815-816
-
-
Varshavsky, A.1
Bachmair, A.2
Finley, D.3
-
20
-
-
33749477365
-
Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells
-
DOI 10.1158/0008-5472.CAN-06-0887
-
Huang X and Guo B: Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. Cancer Res 66: 9245-9251, 2006. (Pubitemid 44521146)
-
(2006)
Cancer Research
, vol.66
, Issue.18
, pp. 9245-9251
-
-
Huang, X.1
Guo, B.2
-
21
-
-
62449226268
-
Valproic acid enhances bosutinib cytotoxicity in colon cancer cells
-
Mologni L, Cleris L, Magistroni V, et al: Valproic acid enhances bosutinib cytotoxicity in colon cancer cells. Int J Cancer 124: 1990-1996, 2009.
-
(2009)
Int J Cancer
, vol.124
, pp. 1990-1996
-
-
Mologni, L.1
Cleris, L.2
Magistroni, V.3
-
22
-
-
84863939925
-
SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin
-
Jin JS, Tsao TJ, Sun PC, Yu CT and Tzao C: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin. Pathol Oncol Res 18: 713-720, 2012.
-
(2012)
Pathol Oncol Res
, vol.18
, pp. 713-720
-
-
Jin, J.S.1
Tsao, T.J.2
Sun, P.C.3
Yu, C.T.4
Tzao, C.5
-
23
-
-
83455246811
-
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells
-
Hsu YF, Sheu JR, Lin CH, et al: Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. Biochim Biophys Acta 1820: 104-115, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1820
, pp. 104-115
-
-
Hsu, Y.F.1
Sheu, J.R.2
Lin, C.H.3
-
24
-
-
21644471962
-
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
-
Young DA, Lakey RL, Pennington CJ, et al: Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther 7: R503-R512, 2005.
-
(2005)
Arthritis Res Ther
, vol.7
-
-
Young, D.A.1
Lakey, R.L.2
Pennington, C.J.3
-
25
-
-
0037067691
-
Acetylation of beta-catenin by CREB-binding protein (CBP)
-
DOI 10.1074/jbc.M201196200
-
Wolf D, Rodova M, Miska EA, Calvet JP and Kouzarides T: Acetylation of beta-catenin by CREB-binding protein (CBP). J Biol Chem 277: 25562-25567, 2002. (Pubitemid 34951872)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.28
, pp. 25562-25567
-
-
Wolf, D.1
Rodova, M.2
Miska, E.A.3
Calvet, J.P.4
Kouzarides, T.5
-
26
-
-
11144353713
-
Acetylation of beta-Catenin by p300 Regulates beta-Catenin-Tcf4 Interaction
-
DOI 10.1128/MCB.24.8.3404-3414.2004
-
Levy L, Wei Y, Labalette C, et al: Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction. Mol Cell Biol 24: 3404-3414, 2004. (Pubitemid 38452083)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.8
, pp. 3404-3414
-
-
Levy, L.1
Wei, Y.2
Labalette, C.3
Wu, Y.4
Renard, C.-A.5
Buendia, M.A.6
Neuveut, C.7
-
27
-
-
0043016178
-
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
-
Nimmanapalli R, Fuino L, Bali P, et al: Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res 63: 5126-5135, 2003. (Pubitemid 37022654)
-
(2003)
Cancer Research
, vol.63
, Issue.16
, pp. 5126-5135
-
-
Nimmanapalli, R.1
Fuino, L.2
Bali, P.3
Gasparetto, M.4
Glozak, M.5
Tao, J.6
Moscinski, L.7
Smith, C.8
Wu, J.9
Jove, R.10
Atadja, P.11
Bhalla, K.12
-
28
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma
-
DOI 10.1126/science.275.5307.1784
-
Korinek V, Barker N, Morin PJ, et al: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275: 1784-1787, 1997. (Pubitemid 27136714)
-
(1997)
Science
, vol.275
, Issue.5307
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Van Wichen, D.4
De Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
29
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, Johnstone RW: Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784, 2006. (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
30
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
-
DOI 10.1074/jbc.C500186200
-
Bali P, Pranpat M, Bradner J, Balasis M, et al: Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 280: 26729-26734, 2005. (Pubitemid 41040705)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.29
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
Balasis, M.4
Fiskus, W.5
Guo, F.6
Rocha, K.7
Kumaraswamy, S.8
Boyapalle, S.9
Atadja, P.10
Seto, E.11
Bhalla, K.12
-
31
-
-
39549088498
-
Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors
-
Park JH, Kim SH, Choi MC, et al: Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors. Biochem Biophys Res Commun 368: 318-322, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.368
, pp. 318-322
-
-
Park, J.H.1
Kim, S.H.2
Choi, M.C.3
-
32
-
-
84869869682
-
HDAC inhibitor-based therapies: Can we interpret the code?
-
New M, Olzscha H and La Thongue NB: HDAC inhibitor-based therapies: Can we interpret the code? Mol Oncol 6: 637-656, 2012.
-
(2012)
Mol Oncol
, vol.6
, pp. 637-656
-
-
New, M.1
Olzscha, H.2
La Thongue, N.B.3
-
33
-
-
69049106387
-
Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells
-
Kurashina R, Ohyashiki JH, Kobayashi C, et al: Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells. Cancer Lett 284: 62-70, 2009.
-
(2009)
Cancer Lett
, vol.284
, pp. 62-70
-
-
Kurashina, R.1
Ohyashiki, J.H.2
Kobayashi, C.3
-
34
-
-
8644265073
-
Antisense Tcf inhibits the neoplastic growth of liver cancer cells
-
DOI 10.1007/s00432-004-0580-9
-
Jiang Y, Zhou XD, Liu YK, et al: Antisense Tcf inhibits the neoplastic growth of liver cancer cells. J Cancer Res Clin Oncol 130: 671-678, 2004. (Pubitemid 39506381)
-
(2004)
Journal of Cancer Research and Clinical Oncology
, vol.130
, Issue.11
, pp. 671-678
-
-
Jiang, Y.1
Zhou, X.-D.2
Liu, Y.-K.3
Huang, X.-W.4
Zhao, Y.5
Xue, Q.6
Sun, R.-X.7
Chen, J.8
Wu, X.9
-
36
-
-
1642341682
-
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells
-
He B, You L, Uematsu K, et al: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6: 7-14, 2004. (Pubitemid 38391944)
-
(2004)
Neoplasia
, vol.6
, Issue.1
, pp. 7-14
-
-
He, B.1
You, L.2
Uematsu, K.3
Xu, Z.4
Lee, A.Y.5
Matsangou, M.6
McCormick, F.7
Jablons, D.M.8
-
37
-
-
58849147900
-
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
-
Minke KS, Staib P, Puetter A, et al: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol 82: 165-175, 2009.
-
(2009)
Eur J Haematol
, vol.82
, pp. 165-175
-
-
Minke, K.S.1
Staib, P.2
Puetter, A.3
-
38
-
-
0035825119
-
Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription
-
DOI 10.1083/jcb.152.1.87
-
Chen S, Guttridge DC, You Z, et al: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol 152: 87-96, 2001. (Pubitemid 32102439)
-
(2001)
Journal of Cell Biology
, vol.152
, Issue.1
, pp. 87-96
-
-
Chen, S.1
Guttridge, D.C.2
You, Z.3
Zhang, Z.4
Fribley, A.5
Mayo, M.W.6
Kitajewski, J.7
Wang, C.-Y.8
|