AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in escherichia coli

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Horiyama, Tsukasa ^a   Nishino, Kunihiko ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENTEROCHELIN; ACRB PROTEIN, E COLI; ACRD PROTEIN, E COLI; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; MDT-A PROTEIN, E COLI; MULTIDRUG RESISTANCE PROTEIN;

ACRB GENE; ACRD GENE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DELETION; GENE FUNCTION; HETEROZYGOTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MDTABC GENE; MDTEF GENE; NONHUMAN; PLASMID; PROTEIN SECRETION; PROTEIN TRANSPORT; TOLC GENE; ANTIBIOTIC RESISTANCE; GENETICS; METABOLISM; TRANSGENIC ORGANISM; TRANSPORT AT THE CELLULAR LEVEL;

ESCHERICHIA COLI;

BIOLOGICAL TRANSPORT; DRUG RESISTANCE, MICROBIAL; ENTEROBACTIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANISMS, GENETICALLY MODIFIED;

EID: 84907439107     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108642     Document Type: Article

References (44)

1. Nikaido H (2011) Structure and mechanism of RND-type multidrug efflux pumps. Adv Enzymol Relat Areas Mol Biol 77: 1-60.
2. Nikaido H (1996) Multidrug efflux pumps of gram-negative bacteria. J Bacteriol 178: 5853-5859.
3. Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443: 173-179.
4. Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A (2011) Structures of the multidrug exporter AcrB reveal a proximal multisite drugbinding pocket. Nature 480: 565-569.
5. Ma D, Cook DN, Hearst JE, Nikaido H (1994) Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol 2: 489-493.
6. Nikaido H, Zgurskaya HI (2001) AcrAB and related multidrug efflux pumps of Escherichia coli. J Mol Microbiol Biotechnol 3: 215-218.
7. Nishino K, Yamada J, Hirakawa H, Hirata T, Yamaguchi A (2003) Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to ß-lactams. Antimicrob Agents Chemother 47: 3030-3033.
8. Bina JE, Mekalanos JJ (2001) Vibrio cholerae tolC is required for bile resistance and colonization. Infect Immun 69: 4681-4685.
9. Rosenberg EY, Bertenthal D, Nilles ML, Bertrand KP, Nikaido H (2003) Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol Microbiol 48: 1609-1619.
10. Thanassi DG, Cheng LW, Nikaido H (1997) Active efflux of bile salts by Escherichia coli. J Bacteriol 179: 2512-2518.
11. Aono R, Tsukagoshi N, Yamamoto M (1998) Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J Bacteriol 180: 938-944.
12. Gilson L, Mahanty HK, Kolter R (1990) Genetic analysis of an MDR-like export system: the secretion of colicin V. EMBO J 9: 3875-3884.
13. Guo X, Harrison RW, Tai PC (2006) Nucleotide-dependent dimerization of the C-terminal domain of the ABC transporter CvaB in colicin V secretion. J Bacteriol 188: 2383-2391.
14. Delgado MA, Vincent PA, Farias RN, Salomon RA (2005) YojI of Escherichia coli functions as a microcin J25 efflux pump. J Bacteriol 187: 3465-3470.
15. Vakharia H, German GJ, Misra R (2001) Isolation and characterization of Escherichia coli tolC mutants defective in secreting enzymatically active alphahemolysin. J Bacteriol 183: 6908-6916.
16. Wandersman C, Delepelaire P (1990) TolC, an Escherichia coli outer membrane protein required for hemolysin secretion. Proc Natl Acad Sci U S A 87: 4776-4780.
17. Fralick JA (1996) Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J Bacteriol 178: 5803-5805.
18. Griffiths E (1991) Iron and bacterial virulence-a brief overview. Biol Met 4: 7-13.
19. O'Brien IG, Gibson F (1970) The structure of enterochelin and related 2,3-dihydroxy-N-benzoylserine conjugates from Escherichia coli. Biochim Biophys Acta 215: 393-402.
20. Pollack JR, Neilands JB (1970) Enterobactin, an iron transport compound from Salmonella typhimurium. Biochem Biophys Res Commun 38: 989-992.
21. Liu J, Quinn N, Berchtold GA, Walsh CT (1990) Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate. Biochemistry 29: 1417-1425.
22. Buchanan SK, Smith BS, Venkatramani L, Xia D, Esser L, et al. (1999) Crystal structure of the outer membrane active transporter FepA from Escherichia coli. Nat Struct Biol 6: 56-63.
23. Rutz JM, Liu J, Lyons JA, Goranson J, Armstrong SK, et al. (1992) Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane. Science 258: 471-475.
24. Bryce GF, Brot N (1972) Studies on the enzymatic synthesis of the cyclic trimer of 2,3-dihydroxy-N-benzoyl-L-serine in Escherichia coli. Biochemistry 11: 1708-1715.
25. Langman L, Young IG, Frost GE, Rosenberg H, Gibson F (1972) Enterochelin system of iron transport in Escherichia coli : mutations affecting ferricenterochelin esterase. J Bacteriol 112: 1142-1149.
26. Greenwood KT, Luke RK (1978) Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia coli K-12. Properties of enterochelin esterase. Biochim Biophys Acta 525: 209-218.
27. Brickman TJ, McIntosh MA (1992) Overexpression and purification of ferric enterobactin esterase from Escherichia coli. Demonstration of enzymatic hydrolysis of enterobactin and its iron complex. J Biol Chem 267: 12350-12355.
28. Furrer JL, Sanders DN, Hook-Barnard IG, McIntosh MA (2002) Export of the siderophore enterobactin in Escherichia coli : involvement of a 43 kDa membrane exporter. Mol Microbiol 44: 1225-1234.
29. Crouch ML, Castor M, Karlinsey JE, Kalhorn T, Fang FC (2008) Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium. Mol Microbiol 67: 971-983.
30. Bleuel C, Grosse C, Taudte N, Scherer J, Wesenberg D, et al. (2005) TolC is involved in enterobactin efflux across the outer membrane of Escherichia coli. J Bacteriol 187: 6701-6707.
31. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, et al. (1997) The complete genome sequence of Escherichia coli K-12. Science 277: 1453-1462.
32. Winkelmann G, Cansier A, Beck W, Jung G (1994) HPLC separation of enterobactin and linear 2,3-dihydroxybenzoylserine derivatives: a study on mutants of Escherichia coli defective in regulation (fur), esterase (fes) and transport (fepA). Biometals 7: 149-154.
33. Datsenko KA, Wanner BL (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97: 6640-6645.
34. Nishino K, Senda Y, Yamaguchi A (2008) The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes. J Infect Chemother 14: 23-29.
35. Nishino K, Senda Y, Hayashi-Nishino M, Yamaguchi A (2009) Role of the AraC-XylS family regulator YdeO in multi-drug resistance of Escherichia coli. J Antibiot 62: 251-257.
36. Nishino K, Yamasaki S, Hayashi-Nishino M, Yamaguchi A (2011) Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli. J Antimicrob Chemother 66: 291-296.
37. Nishino K, Yamasaki S, Hayashi-Nishino M, Yamaguchi A (2010) Effect of NlpE overproduction on multidrug resistance in Escherichia coli. Antimicrob Agents Chemother 54: 2239-2243.
38. Link AJ, Phillips D, Church GM (1997) Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli : application to open reading frame characterization. J Bacteriol 179: 6228-6237.
39. Koronakis V (2003) TolC-the bacterial exit duct for proteins and drugs. FEBS Lett 555: 66-71.
40. Gerken H, Misra R (2004) Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli. Mol Microbiol 54: 620-631.
41. Zgurskaya HI, Nikaido H (1999) Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc Natl Acad Sci U S A 96: 7190-7195.
42. Schwyn B, Neilands JB (1987) Universal chemical assay for the detection and determination of siderophores. Anal Biochem 160: 47-56.
43. Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A (2005) Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol Microbiol 55: 1113-1126.
44. Ruiz C, Levy SB (2014) Regulation of acrAB expression by cellular metabolites in Escherichia coli. J Antimicrob Chemother 69: 390-399.