Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment

Journal of Biological Chemistry

Volumn 289, Issue 39, 2014, Pages 27146-27158

  Shao, Zhifei ^a,b   Morser, John ^a,b   Leung, Lawrence L K ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS;

C-TERMINAL FRAGMENTS; CARBOXYPEPTIDASE; CHEMOTACTIC ACTIVITY; CLEAVAGE SITES; DENDRITIC CELLS; FUNCTIONAL DOMAINS; INTACT PROTEINS; INTEGRIN-BINDING SITE;

ENZYMES;

ARGINYLGLYCYLASPARTIC ACID; CARBOXYPEPTIDASE; CARBOXYPEPTIDASE B2; OSTEOPONTIN; RECOMBINANT OSTEOPONTIN; RECOMBINANT PROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; THROMBIN; UNCLASSIFIED DRUG; CCL12 PROTEIN, MOUSE; CD44 PROTEIN, HUMAN; CD44 PROTEIN, MOUSE; HERMES ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN; SPP1 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SECRETION; ANIMAL; CELL MOTION; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD44; CELL MOVEMENT; DENDRITIC CELLS; HUMANS; MICE; MICE, KNOCKOUT; MONOCYTE CHEMOATTRACTANT PROTEINS; OSTEOPONTIN; PROTEOLYSIS; THROMBIN;

EID: 84907437823     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.572172     Document Type: Article

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