Expression of P2X7 ATP receptor mediating the IL8 and CCL20 release in human periodontal ligament stem cells

Journal of Cellular Biochemistry

Volumn 115, Issue 6, 2014, Pages 1138-1146

  Trubiani, Oriana ^a   Horenstein, Alberto L ^b   Caciagli, Francesco ^a   Caputi, Sergio ^a   Malavasi, Fabio ^b   Ballerini, Patrizia ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

CYTOKINES; INFLAMMATION; P2X7; PERIODONTAL LIGAMENT; STEM CELLS

Indexed keywords

2' ,3' (BENZOYL 4 BENZOYL) ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM; ETHIDIUM BROMIDE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PURINERGIC P2X7 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; (N-(1-(((CYANOIMINO)(5-QUINOLINYLAMINO) METHYL) AMINO)-2,2-DIMETHYLPROPYL)-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE); 2',3'-DIALDEHYDE ATP; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; ACETAMIDE DERIVATIVE; CCL20 PROTEIN, HUMAN; INTERLEUKIN 8; QUINOLINE DERIVATIVE;

ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CYTOFLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WESTERN BLOTTING; ADULT; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; METABOLISM; SCANNING ELECTRON MICROSCOPY; TIME; ULTRASTRUCTURE; YOUNG ADULT;

ACETAMIDES; ADENOSINE TRIPHOSPHATE; ADULT; BLOTTING, WESTERN; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL20; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-8; MICROSCOPY, ELECTRON, SCANNING; PERIODONTAL LIGAMENT; QUINOLINES; RECEPTORS, PURINERGIC P2X7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TIME FACTORS; YOUNG ADULT;

EID: 84907421651     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24756     Document Type: Article

References (34)

1. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA,. 2006. International union of pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58: 281-341.
2. Ballerini P, Rathbone MP, Di Iorio P, Renzetti A, Giuliani P, D'Alimonte I, Trubiani O, Caciagli F, Ciccarelli R,. 1996. Rat astroglial P2Z (P2X7) receptors regulate intracellular calcium and purine release. Neuroreport 7: 2533-2537.
3. Ballerini P, Ciccarelli R, Caciagli F, Rathbone MP, Werstiuk ES, Traversa U, Buccella S, Giuliani P, Jang S, Nargi E, Visini D, Santavenere C, Di Iorio P,. 2005. P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes. Int J Immunopathol Pharmacol 18: 417-430.
4. Beigi RD, Kertesy SB, Aquilina G, Dubyak GR,. 2003. Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol 140: 507-519.
5. Budagian V, Bulanova E, Brovko L, Orinska Z, Fayad R, Paus R, Bulfone-Paus S,. 2003. Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B. J Biol Chem 278: 1549-1560.
6. Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Júnior WM, Rossi MA, Silva JS,. 2009. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol 24: 1-6.
7. Carroll WA, Donnelly-Roberts D, Jarvis MF,. 2009. Selective P2X7 receptor antagonists for chronic inflammation and pain. Purinergic Signal 5: 63-73.
8. Chessell IP, Michel AD, Humphrey PP,. 1997. Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cells. Br J Pharmacol 121: 1429-1437.
9. D'Alimonte I, Ciccarelli R, Di Iorio P, Nargi E, Buccella S, Giuliani P, Rathbone MP, Jiang S, Caciagli F, Ballerini P,. 2007. Activation of P2X7 receptors stimulates the expression of P2Y2 receptor mRNA in astrocytes cultured from rat brain. Int J Immunopathol Pharmacol 20: 301-316.
10. Di Virgilio F, Falzoni S, Chiozzi P, Sanz JM, Ferrari D, Buell GN,. 1999. ATP receptors and giant cell formation. J Leukoc Biol 66: 723-726.
11. Donnelly-Roberts DL, Namovic MT, Han P, Jarvis MF,. 2009. Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157: 1203-1214.
12. Eleuterio E, Trubiani O, Sulpizio M, Di Giuseppe F, Pierdomenico L, Marchisio M, Giancola R, Giammaria G, Miscia S, Caputi S, Di Ilio C, Angelucci S,. 2013. Proteome of human stem cells from periodontal ligament and dental pulp. PLoS ONE 8: e71101.
13. Ferrari D, Gulinelli S, Salvestrini V, Lucchetti G, Zini R, Manfredini R, Caione L, Piacibello W, Ciciarello M, Rossi L, Idzko M, Ferrari S, Di Virgilio F, Lemoli RM,. 2011. Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines. Exp Hematol 39: 360-374.
14. Gramonal J, Acevedo A, Bascones A, Jorge O, Silva A,. 2000. Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 71: 1535-1545.
15. Grol MW, Zelner I, Dixon SJ,. 2011. P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. Am J Physiol Endocrinol Metab 302: 561-575.
16. Hosokawa Y, Nakanishi T, Yamaguchi D, Takahashi K, Yumoto H, Ozaki K, Matsuo T,. 2002. Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. Clin Exp Immunol 128: 548-554.
17. Jarvis MF, Khakh BS,. 2009. ATP-gated P2X cation-channels. Neuropharmacology 56: 208-215.
18. Kanjanamekanant K, Luckprom P, Pavasant P,. 2013. Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate/P2X7 receptor activation in human periodontal ligament cells. J Periodontal Res 48: 169-176.
19. Kawase T, Okuda K, Yoshie H,. 2007. Extracellular ATP and ATPgammaS suppress the proliferation of human periodontal ligament cells by different mechanisms. J Periodontol 78: 748-756.
20. Malavasi F, Deaglio S, Zaccarello G, Horenstein AL, Chillemi A, Audrito V, Serra S, Gandione M, Zitella A, Tizzani A,. 2010. The hidden life of NAD+-consumingectoenzymes in the endocrine system. J Mol Endocrinol 45: 183-191.
21. Orciani M, Trubiani O, Vignini A, Mattioli-Belmonte M, Di Primio R, Salvolini E,. 2009. Nitric oxide production during the osteogenic differentiation of human periodontal ligament mesenchymal stem cells. Acta Histochem 111: 15-24.
22. Orriss IR, Key ML, Brandao-Burch A, Patel JJ, Bumstock G, Amett TR,. 2012. The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of P2X receptors. Bone 51: 389-400.
23. Pellegatti P, Falzoni S, Pinton P, Rizzuto R, Di Virgilio F,. 2005. A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol Biol Cell 16: 3659-3665.
24. Piccini A, Carta S, Tassi S, Lasiglié D, Fossati G, Rubartelli A,. 2008. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc Natl Acad Sci USA 105: 8067-8072.
25. Seo BM, Miure M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S,. 2004. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155.
26. Serra S, Horenstein AL, Vaisitti T, Brusa D, Rossi D, Laurenti L, D'Arena G, Coscia M, Tripodo C, Inghirami G, Robson SC, Gaidano G, Malavasi F, Deaglio S,. 2011. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood 118: 6141-6152.
27. Stock TC, Bloom BJ, Wei N, Ishaq S, Park W, Wang X, Gupta P, Mebus CA,. 2012. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol 39: 720-727.
28. Tartour E, Pere H, Maillere B, Terme M, Merillon N, Taieb J, Sandoval F, Quintin-Colonna F, Lacerda K, Karadimou A, Badoual C, Tedgui A, Fridman WH, Oudard S,. 2011. Angiogenesis and immunity: A bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy. Cancer Metastasis Rev 30: 83-95.
29. Trubiani O, Isgro A, Zini N, Antonucci I, Aiuti F, Di Primio R, Nanci A, Caputi S, Paganelli R,. 2008. Functional interleukin-7/interleukin-7Ralpha, and SDF-1alpha/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells. J Cell Physiol 214: 706-713.
30. Trubiani O, Zalzal SF, Paganelli R, Marchisio M, Giancola R, Pizzicannella J, Bühring HJ, Piattelli M, Caputi S, Nanci A,. 2010. Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J Cell Physiol 225: 123-131.
31. Trubiani O, Ballerini P, Murmura G, Pizzicannella J, Giuliani P, Buccella S, Caputi S,. 2012a. Toll-like receptor 4 expression, interleukin-6, -8 and CCL-20 release, and NF-kB translocation in human periodontal ligament mesenchymal stem cells stimulated with LPS-Gingivalis. Eur J Inflammation 25: 637-643.
32. Trubiani O, Cataldi A, De Angelis F, D'Arcangelo C, Caputi S,. 2012b. Overexpression of interleukine-6 and -8, cell growth and morphological changes in 2-hydroxyethyl methacrylate-treated humandental pulp mesenchymal stem cells. Int Endod J 45: 19-25.
33. Wei W, Ryu JK, Choi HB, McLarnon JG,. 2008. Expression and function of the P2X7 receptor in rat C6 glioma cells. Cancer Lett 260: 79-87.
34. Wongkhantee S, Yongchaitrakul T, Pavasant P,. 2008. Mechanical stress induces osteopontin via ATP/P2Y1 in periodontal cells. J Dent Res 87: 564-568.