Glomerular hypertrophy in subjects with low nephron number: Contributions of sex, body size and race

Nephrology Dialysis Transplantation

Volumn 29, Issue 9, 2014, Pages 1686-1695

  Puelles, Victor G ^a   Douglas Denton, Rebecca N ^a   Zimanyi, Monika A ^a,b   Armitage, James A ^a,c   Hughson, Michael D ^d   Kerr, Peter G ^a,e   Bertram, John F ^a  

^a MONASH UNIVERSITY   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

^c DEAKIN UNIVERSITY   (Australia)

^d UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^e SOUTHERN HEALTH   (Australia)

Author keywords

Body size; Glomerular hypertrophy; Nephron number; Race; Sex

Indexed keywords

ADULT; AFRICAN AMERICAN; AGE DISTRIBUTION; ARTICLE; AUTOPSY; BODY MASS; BODY SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; EUROPEAN AMERICAN; FEMALE; GEOGRAPHIC DISTRIBUTION; GLOMERULAR STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; KIDNEY HYPERTROPHY; MALE; NEPHRON; OBESITY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RACE DIFFERENCE; SEX DIFFERENCE; STEREOLOGY; BODY SIZE; CLINICAL ARTICLE; HISTOPATHOLOGY; INDIVIDUAL GLOMERULAR VOLUME; KIDNEY PARENCHYMA; NEPHRON NUMBER; RENAL SYSTEM PARAMETERS; RISK FACTOR; UNITED STATES; CAUCASIAN; GLOMERULUS; HYPERTROPHY; MIDDLE AGED; PATHOLOGY; STATISTICS AND NUMERICAL DATA;

ANTIHYPERTENSIVE AGENT;

ADULT; AFRICAN AMERICANS; BODY SIZE; BODY SURFACE AREA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; HYPERTROPHY; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; NEPHRONS; SEX FACTORS;

EID: 84907419992     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu088     Document Type: Article

References (69)

1. Blagg CR. Preface. Hemodial Int 2011; 15: 177
2. Levey AS, Coresh J. Chronic kidney disease. Lancet 2012; 379: 165-180
3. James MT, Hemmelgarn BR, Tonelli M. Early recognition and prevention of chronic kidney disease. Lancet 2010; 375: 1296-1309
4. Puelles VG, Hoy WE, Hughson MD et al. Glomerular number and size variability and risk for kidney disease. Curr Opin Nephrol Hypertens 2011; 20: 7-15
5. Luyckx VA, Brenner BM. The clinical importance of nephron mass. J Am Soc Nephrol 2010; 21: 898-910
6. Hoy WE, Hughson MD, Bertram JF et al. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol 2005; 16: 2557-2564
7. Hughson MD, Gobe GC, Hoy WE et al. Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites. Am J Kidney Dis 2008; 52: 18-28
8. Luyckx VA, Bertram JF, Brenner BM et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet 2013; 382: 273-283
9. Brenner BM. Nephron adaptation to renal injury or ablation. Am J Physiol 1985; 249(3 Pt 2): F324-F337
10. Young RJ, Hoy WE, Kincaid-Smith P et al. Glomerular size and glomerulosclerosis in Australian aborigines. Am J Kidney Dis 2000; 36: 481-489
11. Ijpelaar DH, Schulz A, Koop K et al. Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich- Wistar-Fromter rats. Am J Physiol Renal Physiol 2008; 294: F758-F767
12. Stackhouse S, Miller PL, Park SK et al. Reversal of glomerular hyperfiltration and renal hypertrophy by blood glucose normalization in diabetic rats. Diabetes 1990; 39: 989-995
13. Fabris B, Candido R, Armini L et al. Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats. J Hypertens 1999; 17(12 Pt 2): 1925-1931
14. Lemley KV. A basis for accelerated progression of diabetic nephropathy in Pima Indians. Kidney Int Suppl 2003; S38-S42
15. Hughson MD, Hoy WE, Douglas-Denton RN et al. Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations. Nephrol Dial Transplant 2011; 26: 2202-2208
16. Neugarten J, Golestaneh L. Gender and the prevalence and progression of renal disease. Adv Chronic Kidney Dis 2013; 20: 390-395
17. Neugarten J, Acharya A, Silbiger SR. Effect of gender on the progression of nondiabetic renal disease: a meta-analysis. J Am Soc Nephrol 2000; 11: 319-329
18. Silbiger S, Neugarten J. Gender and human chronic renal disease. Gend Med 2008; 5(Suppl A): S3-S10
19. Silbiger SR, Neugarten J. The role of gender in the progression of renal disease. Adv Ren Replace Ther 2003; 10: 3-14
20. Hughson MD, Douglas-Denton R, Bertram JF et al. Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States. Kidney Int 2006; 69: 671-678
21. Neugarten J, Kasiske B, Silbiger SR et al. Effects of sex on renal structure. Nephron 2002; 90: 139-144
22. Tan JC, Paik J, Chertow GM et al. Validity of surrogate measures for functional nephron mass. Transplantation 2011; 92: 1335-1341
23. Tsuboi N, Utsunomiya Y, Koike K et al. Factors related to the glomerular size in renal biopsies of chronic kidney disease patients. Clin Nephrol 2013; 79: 277-284
24. Hoy WE, Douglas-Denton RN, Hughson MD et al. A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 2003; S31-S37
25. Hughson M, Farris AB, III, Douglas-Denton R et al. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003; 63: 2113-2122
26. Douglas-Denton RN, McNamara BJ, Hoy WE et al. Does nephron number matter in the development of kidney disease? Ethn Dis 2006; 16(2 Suppl 2): S2-40-5.
27. Bertram JF, Douglas-Denton RN, Diouf B et al. Human nephron number: implications for health and disease. Pediatr Nephrol 2011; 26: 1529-1533
28. Samuel T, Hoy WE, Douglas-Denton R et al. Determinants of glomerular volume in different cortical zones of the human kidney. J Am Soc Nephrol 2005; 16: 3102-3109
29. Zimanyi MA, Hoy WE, Douglas-Denton RN et al. Nephron number and individual glomerular volumes in male Caucasian and African American subjects. Nephrol Dial Transplant 2009; 24: 2428-2433
30. Eknoyan G. Adolphe Quetelet (1796-1874)-the average man and indices of obesity. Nephrol Dial Transplant 2008; 23: 47-51
31. Mosteller RD. Simplified calculation of body-surface area. N Engl J Med 1987; 317: 1098
32. Hughson MD, Puelles VG, Hoy WE et al. (December 9, 2013). Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. Nephrol Dial Transplant 2014; 29: 1399-1409
33. McNamara BJ, Diouf B, Douglas-Denton RN et al. A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Americans. Nephrol Dial Transplant 2010; 25: 1514-1520
34. McNamara BJ, Diouf B, Hughson MD et al. Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 2009; 24: 1500-1506
35. Hoy WE, Hughson MD, Singh GR et al. Reduced nephron number and glomerulomegaly in Australian Aborigines: a group at high risk for renal disease and hypertension. Kidney Int 2006; 70: 104-110
36. Puelles VG, Zimanyi MA, Samuel T et al. Estimating individual glomerular volume in the human kidney: clinical perspectives. Nephrol Dial Transplant 2012; 27: 1880-1888
37. Hoy WE, Hughson MD, Diouf B et al. Distribution of volumes of individual glomeruli in kidneys at autopsy: association with physical and clinical characteristics and with ethnic group. Am J Nephrol 2011; 33(Suppl 1): 15-20
38. Hoy WE, Hughson MD, Zimanyi M et al. Distribution of volumes of individual glomeruli in kidneys at autopsy: association with age, nephron number, birth weight and body mass index. Clin Nephrol 2010; 74(Suppl 1): S105-S112
39. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 1984; 134(Pt 2): 127-136
40. Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol 1995; 161: 111-172
41. Akaoka K, White RH, Raafat F. Human glomerular growth during childhood: a morphometric study. J Pathol 1994; 173: 261-268
42. Cortes P, Zhao X, Dumler F et al. Age-related changes in glomerular volume and hydroxyproline content in rat and human. J Am Soc Nephrol 1992; 2: 1716-1725
43. Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 1996; 49: 1774-1777
44. Walker KA, Bertram JF. Kidney development: core curriculum 2011. Am J Kidney Dis 2011; 57: 948-958
45. Luyckx VA, Brenner BM. Low birth weight, nephron number, and kidney disease. Kidney Int Suppl 2005; S68-S77
46. Eschwege P, Trifa M, Randrianjohany A et al. Effects of donor and recipient weight differences on serum creatinine levels in renal transplantation. Transplant Proc 1995; 27: 2456
47. Moreso F, Seron D, Anunciada AI et al. Recipient body surface area as a predictor of posttransplant renal allograft evolution. Transplantation 1998; 65: 671-676
48. Cannon RM, Jones CM, Hughes MG et al. The impact of recipient obesity on outcomes after renal transplantation. Ann Surg 2013; 257: 978-984
49. Aalten J, Christiaans MH, de Fijter H et al. The influence of obesity on short- and long-term graft and patient survival after renal transplantation. Transpl Int 2006; 19: 901-907
50. Oh CK, Jeon KO, Kim HJ et al. Metabolic demand and renal mass supply affecting the early graft function after living donor kidney transplantation. Kidney Int 2005; 67: 744-749
51. Tent H, Lely AT, Toering TJ et al. Donor kidney adapts to body dimensions of recipient: no influence of donor gender on renal function after transplantation. Am J Transplant 2011; 11: 2173-2180
52. McLachlan MS, Gaunt A, Fulker MJ et al. Estimation of glomerular size and number from radiographs of the kidney. Br J Radiol 1976; 49: 831-835
53. Ellis EN, Mauer SM, Sutherland DE et al. Glomerular capillary morphology in normal humans. Lab Invest 1989; 60: 231-236
54. Abdi R, Slakey D, Kittur D et al . Heterogeneity of glomerular size in normal donor kidneys: impact of race. Am J Kidney Dis 1998; 32: 43-46
55. Hoy WE, Bertram JF, Denton RD et al. Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 2008; 17: 258-265
56. Chevalier RL, Forbes MS. Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 2008; 19: 197-206
57. Beeman SC, Zhang M, Gubhaju L et al. Measuring glomerular number and size in perfused kidneys using MRI. Am J Physiol Renal Physiol 2011; 300: F1454-F1457
58. Heilmann M, Neudecker S, Wolf I et al. Quantification of glomerular number and size distribution in normal rat kidneys using magnetic resonance imaging. Nephrol Dial Transplant 2012; 27: 100-107
59. Bennett KM, Bertram JF, Beeman SC et al. (March 20, 2013). Invited review: the emerging role of MRI in quantitative renal glomerular morphology. Am J Physiol Renal Physiol 2013; 304: F1252-F1257
60. Chagnac A, Weinstein T, Herman M et al. The effects of weight loss on renal function in patients with severe obesity. J Am Soc Nephrol 2003; 14: 1480-1486
61. Shimomura Y, Murakami M, Shimizu H et al. Improvement of nephrotic syndrome in a massively obese patient after weight loss and treatment with an anti-allergic drug. J Med 1990; 21: 337-347
62. Bolignano D, Zoccali C. Effects of weight loss on renal function in obese CKD patients: a systematic review. Nephrol Dial Transplant 2013; 28 (Suppl 4): iv82-iv98
63. Silverwood RJ, Pierce M, Thomas C et al. Association between younger age when first overweight and increased risk for CKD. J Am Soc Nephrol 2013; 24: 813-821
64. Silverwood RJ, Pierce M, Hardy R et al. Early-Life Overweight Trajectory and CKD in the 1946 British Birth Cohort Study. Am J Kidney Dis 2013; 62: 276-284
65. Silverwood RJ, Pierce M, Hardy R et al. (June 12, 2013). Low birth weight, later renal function, and the roles of adulthood blood pressure, diabetes, and obesity in a British birth cohort. Kidney Int 2013; 84: 1262-1270
66. Chew-Harris JS, Florkowski CM, George PM et al. The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Ann Clin Biochem 2013; 50(Pt 1): 39-46
67. Genovese G, Friedman DJ, Ross MD et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010; 329: 841-845
68. Kopp JB, Nelson GW, Sampath K et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 2011; 22: 2129-2137
69. Keller G, Zimmer G, Mall G et al. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348: 101-108