Towards a definition of glomerulomegaly: Clinicalpathological and methodological considerations

Nephrology Dialysis Transplantation

Volumn 26, Issue 7, 2011, Pages 2202-2208

  Hughson, Michael D ^a   Hoy, Wendy E ^b   Douglas Denton, Rebecca N ^c   Zimanyi, Monika A ^c   Bertram, John F ^c  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

body mass index; glomerular number; glomerulomegaly; hypertension

Indexed keywords

ADULT; AFRICAN AMERICAN; AGED; ANALYTIC METHOD; ARTICLE; AUTOPSY; BODY MASS; CAUCASIAN; CAVALIERI METHOD; CONTROLLED STUDY; FRACTIONATOR TECHNIQUE; GLOMERULOMEGALY; GLOMERULOPATHY; GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; HYPERTENSION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MEASUREMENT; PRIORITY JOURNAL; RACE DIFFERENCE; ETHNOLOGY; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS; MALE; MIDDLE AGED; OBESITY; PATHOLOGY; STATISTICS;

ADULT; AFRICAN AMERICANS; AGED; AUTOPSY; BODY MASS INDEX; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; HYPERTENSION; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; OBESITY; YOUNG ADULT;

EID: 79959926984     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq688     Document Type: Article

References (28)

1. Fogo A, Ichikawa I. Evidence for a pathogenic link between glomerular hypertrophy and sclerosis. Am J Kidney Dis 1991; 17: 666-669.
2. Fogo A, Hawkins EP, Berry PL et al. Glomerular hypertrophy in minimal change disease predicts subsequent progression to focal glomerulosclerosis. Kidney Int 1990; 38: 115-123. (Pubitemid 20209440)
3. Broyer M, Soto B, Gagnadoux M-F et al. Oligomeganephronic renal hypoplasia. Adv Nephrol 1997; 26: 47-63.
4. Pesce CM, Schmidt K, Fogo A et al. Glomerular size and the incidence of renal disease in African Americans and Caucasians. J Nephrol 1994; 7: 355-358.
5. Schmidt K, Pesce C, Liu QL et al. Large glomerular size in Pima Indians: lack of change with diabetic nephropathy. J Am Soc Nephrol 1992; 3: 229-235.
6. Abdi R, Slakey D, Kittur D et al. Heterogeneity of glomerular size in normal donor kidneys. Impact of race. Am J Kidney Dis 1998; 32: 43-46. (Pubitemid 28311869)
7. Bertram JF, Young RJ, Seymour AE et al. Glomerulomegaly in Australian Aborigines. Nephrology 1998; 4: S46-S53. (Pubitemid 29091059)
8. Adelman RD, Restaino IG, Alon US et al. Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents. J Pediatr 2001; 138: 481-485. (Pubitemid 32319719)
9. Kambham N, Markowitz GS, Valeri AM et al. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int 2001; 59: 1498-1509. (Pubitemid 32281241)
10. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 1984; 134: 127-136. (Pubitemid 14121386)
11. Praga M, Hernandez E, Morales E et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16: 1790-1798. (Pubitemid 32821410)
12. Cortes P, Riser B, Narins RG. Glomerular hypertension and progressive renal disease: the interplay of mesangial stretch, cytokine formation and extracellular matrix synthesis. Contrib Nephrol 1996; 188: 229-233.
13. Macconi D, Sangalli F, Bonomelli m et al. Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition. Am J Pathol 2009; 174: 797-807.
14. Hughson M, Farris AB, Douglas-Denton RN et al. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003; 63: 2113-2122. (Pubitemid 36605822)
15. Merlet-Benichou C, Gilbert T, Vilar J et al. Nephron number: variability is the rule. Lab Invest 1999; 79: 515-527.
16. Samuel T, Hoy WE, Douglas-Denton R et al. Determinants of glomerular volume in different cortical zones of the human kidney. J Am Soc Nephrol 2005; 16: 3102-3109. (Pubitemid 44743508)
17. Hughson MD, Douglas-Denton R, Bertram JF et al. Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States. Kidney Int 2006; 69: 671-678. (Pubitemid 43237635)
18. Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol 1995; 161: 111-172.
19. Nyengaard JR. Stereologic methods and their application in kidney research. Estimating total glomerular number in human kidneys with a physical dissector/fractionator combination. Image Anal Stereol 2000; 19: 105-108.
20. Johnson KJ, Wreford NG, Hoy WE et al. Estimating total glomerular number in human kidneys with a dissector/fractionator combination. Image Anal Stereol 2000; 19: 105-108.
21. McNamara BJ, Diouf B, Hughson MD et al. Renal pathology, glomerular number and volume in a West African urban community. Nephrol Dial Transplant 2008; 23: 2576-2585.
22. Zimanyi MA, Hoy WE, Douglas-Denton RN et al. Nephron number and individual glomerular volumes in male Caucasians and African American subjects. Nephrol Dial Transplant 2009; 24: 2428-2433.
23. McNamara BJ, Diouf B, Hughson MD et al. Associations between age, body size, and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 2009; 24: 1500-1506.
24. Hughson MD. End-stage renal disease. In: JC Jennette, JL Olson, MM Schwartz, FG Silva (eds). Heptinstall's Pathology of the Kidney. 6th edn. Philadelphia, PA: Williams & Wilkins, 2006; 1000.
25. Slomianka L. Blue Histology-a brief introduction to stereology. School of Anatomy and Human Biology-The University of Western Australiawww.lab.anhb.uaw. edu.au.
26. Aherne WA, Dunnill MS. Morphometry. London: Edward Arnold, 1982; 205.
27. Keller G, Zimmer G, Mall G et al. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348: 101-108. (Pubitemid 36056716)
28. Hall JE. The kidney, hypertension, and obesity. Hypertension 2003; 41: 625-633 (Pubitemid 36314565)