Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart

Cell Reports

Volumn 8, Issue 6, 2014, Pages 1741-1751

  Villa del Campo, Cristina ^a   Clavería, Cristina ^a   Sierra, Rocío ^a   Torres, Miguel ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MYC PROTEIN; PROTEIN P53; CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; INTEGRASE; LIM HOMEODOMAIN PROTEIN; NKX2-5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADULT; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL HETEROGENEITY; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; GASTRULATION; HEART DEVELOPMENT; HEART FUNCTION; HEART MUSCLE CELL; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PREGNANCY; PROTEIN EXPRESSION; STEM CELL; WILD TYPE; ANATOMY AND HISTOLOGY; ANIMAL; ANIMAL EMBRYO; APOPTOSIS; CYTOLOGY; FEMALE; GENETIC RECOMBINATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; MALE; METABOLISM; PHYSIOLOGY;

MAMMALIA;

ANIMALS; APOPTOSIS; EMBRYO, MAMMALIAN; FEMALE; GREEN FLUORESCENT PROTEINS; HEART; HOMEODOMAIN PROTEINS; INTEGRASES; LIM-HOMEODOMAIN PROTEINS; MALE; MICE; MYOCYTES, CARDIAC; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINATION, GENETIC; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84907390474     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.08.005     Document Type: Article

References (45)

1. Baker N.E. Cell competition. Curr. Biol. 2011, 21:R11-R15.
2. Bondar T., Medzhitov R. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 2010, 6:309-322.
3. Clavería C., Albar J.P., Serrano A., Buesa J.M., Barbero J.L., Martínez-A C., Torres M. Drosophila grim induces apoptosis in mammalian cells. EMBO J. 1998, 17:7199-7208.
4. Clavería C., Giovinazzo G., Sierra R., Torres M. Myc-driven endogenous cell competition in the early mammalian embryo. Nature 2013, 500:39-44.
5. Dang C.V. MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med 2013, 3.
6. Davis A.C., Wims M., Spotts G.D., Hann S.R., Bradley A. A null c-myc mutation causes lethality before 10.5days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 1993, 7:671-682.
7. de Beco S., Ziosi M., Johnston L.A. New frontiers in cell competition. Dev. Dyn. 2012, 241:831-841.
8. de la Cova C., Abril M., Bellosta P., Gallant P., Johnston L.A. Drosophila myc regulates organ size by inducing cell competition. Cell 2004, 117:107-116.
9. Drenckhahn J.D., Schwarz Q.P., Gray S., Laskowski A., Kiriazis H., Ming Z., Harvey R.P., Du X.J., Thorburn D.R., Cox T.C. Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development. Dev. Cell 2008, 15:521-533.
10. Durgan D.J., Young M.E. The cardiomyocyte circadian clock: emerging roles in health and disease. Circ. Res. 2010, 106:647-658.
11. Evans S.M., Yelon D., Conlon F.L., Kirby M.L. Myocardial lineage development. Circ. Res. 2010, 107:1428-1444.
12. Gallant P. Myc function in Drosophila. Cold Spring Harb Perspect Med 2013, 3:a014324.
13. García-Prieto J., García-Ruiz J.M., Sanz-Rosa D., Pun A., García-Alvarez A., Davidson S.M., Fernández-Friera L., Nuno-Ayala M., Fernández-Jiménez R., Bernal J.A., et al. β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes. Basic Res. Cardiol. 2014, 109:422.
14. Hay B.A., Wolff T., Rubin G.M. Expression of baculovirus P35 prevents cell death in Drosophila. Development 1994, 120:2121-2129.
15. Hurlin P.J. Control of vertebrate development by MYC. Cold Spring Harb Perspect Med 2013, 3:a014332.
16. Jackson T., Allard M.F., Sreenan C.M., Doss L.K., Bishop S.P., Swain J.L. The c-myc proto-oncogene regulates cardiac development in transgenic mice. Mol. Cell. Biol. 1990, 10:3709-3716.
17. Kelly R.G., Brown N.A., Buckingham M.E. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev. Cell 2001, 1:435-440.
18. Kishimoto I., Rossi K., Garbers D.L. A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Proc. Natl. Acad. Sci. USA 2001, 98:2703-2706.
19. Knaapen M.W., Davies M.J., De Bie M., Haven A.J., Martinet W., Kockx M.M. Apoptotic versus autophagic cell death in heart failure. Cardiovasc. Res. 2001, 51:304-312.
20. Kuhn M., Holtwick R., Baba H.A., Perriard J.C., Schmitz W., Ehler E. Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor (GC-A) deficient mice. Heart 2002, 87:368-374.
21. Lee K.S., Park J.H., Lim H.J., Park H.Y. HB-EGF induces cardiomyocyte hypertrophy via an ERK5-MEF2A-COX2 signaling pathway. Cell. Signal. 2011, 23:1100-1109.
22. Levayer R., Moreno E. Mechanisms of cell competition: themes and variations. J.Cell Biol. 2013, 200:689-698.
23. Levens D. Cellular MYCro economics: Balancing MYC function with MYC expression. Cold Spring Harb Perspect Med 2013, 3.
24. Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
25. Madonna R., Cevik C., Nasser M., De Caterina R. Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration. Thromb. Haemost. 2012, 107:656-661.
26. Martin D.N., Baehrecke E.H. Caspases function in autophagic programmed cell death in Drosophila. Development 2004, 131:275-284.
27. Marusyk A., Porter C.C., Zaberezhnyy V., DeGregori J. Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol. 2010, 8:e1000324.
28. Morata G., Ripoll P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 1975, 42:211-221.
29. Moreno E., Basler K. dMyc transforms cells into super-competitors. Cell 2004, 117:117-129.
30. Murphy D.J., Junttila M.R., Pouyet L., Karnezis A., Shchors K., Bui D.A., Brown-Swigart L., Johnson L., Evan G.I. Distinct thresholds govern Myc's biological output invivo. Cancer Cell 2008, 14:447-457.
31. Nieminen A.I., Eskelinen V.M., Haikala H.M., Tervonen T.A., Yan Y., Partanen J.I., Klefström J. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc. Natl. Acad. Sci. USA 2013, 110:E1839-E1848.
32. Poelmann R.E., Molin D., Wisse L.J., Gittenberger-de Groot A.C. Apoptosis in cardiac development. Cell Tissue Res. 2000, 301:43-52.
33. Rana M.S., Christoffels V.M., Moorman A.F. A molecular and genetic outline of cardiac morphogenesis. Acta Physiol. (Oxf.) 2013, 207:588-615.
34. Sancho M., Di-Gregorio A., George N., Pozzi S., Sánchez J.M., Pernaute B., Rodríguez T.A. Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation. Dev. Cell 2013, 26:19-30.
35. Shah B.H., Catt K.J. A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy. Trends Pharmacol. Sci. 2003, 24:239-244.
36. Sohal D.S., Nghiem M., Crackower M.A., Witt S.A., Kimball T.R., Tymitz K.M., Penninger J.M., Molkentin J.D. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ. Res. 2001, 89:20-25.
37. Soonpaa M.H., Kim K.K., Pajak L., Franklin M., Field L.J. Cardiomyocyte DNA synthesis and binucleation during murine development. Am. J. Physiol. 1996, 271:H2183-H2189.
38. Stanley E.G., Biben C., Elefanty A., Barnett L., Koentgen F., Robb L., Harvey R.P. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 2002, 46:431-439.
39. Tamori Y., Deng W.M. Tissue repair through cell competition andcompensatory cellular hypertrophy in postmitotic epithelia. Dev. Cell 2013, 25:350-363.
40. Tsai J.Y., Kienesberger P.C., Pulinilkunnil T., Sailors M.H., Durgan D.J., Villegas-Montoya C., Jahoor A., Gonzalez R., Garvey M.E., Boland B., et al. Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. J.Biol. Chem. 2010, 285:2918-2929.
41. Tyler D.M., Li W., Zhuo N., Pellock B., Baker N.E. Genes affecting cell competition in Drosophila. Genetics 2007, 175:643-657.
42. Vincent S.D., Buckingham M.E. How to make a heart: the origin and regulation of cardiac progenitor cells. Curr. Top. Dev. Biol. 2010, 90:1-41.
43. Vincent J.P., Fletcher A.G., Baena-Lopez L.A. Mechanisms andmechanics of cell competition in epithelia. Nat. Rev. Mol. Cell Biol. 2013, 14:581-591.
44. Xiao G., Mao S., Baumgarten G., Serrano J., Jordan M.C., Roos K.P., Fishbein M.C., MacLellan W.R. Inducible activation of c-Myc in adult myocardium invivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. Circ. Res. 2001, 89:1122-1129.
45. Yang L., Cai C.L., Lin L., Qyang Y., Chung C., Monteiro R.M., Mummery C.L., Fishman G.I., Cogen A., Evans S. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 2006, 133:1575-1585.