β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes

Basic Research in Cardiology

Volumn 109, Issue 4, 2014, Pages

  García Prieto, Jaime ^a   García Ruiz, Jose Manuel ^a,b   Sanz Rosa, David ^a   Pun, Andrés ^a   García Alvarez, Ana ^a,c   Davidson, Sean M ^d   Fernández Friera, Leticia ^a,e   Nuno Ayala, Mario ^a   Fernández Jiménez, Rodrigo ^a   Bernal, Juan A ^a   Izquierdo Garcia, José Luis ^a,f   Jimenez Borreguero, Jesús ^a   Pizarro, Gonzalo ^a,g   Ruiz Cabello, Jesús ^a,f   Macaya, Carlos ^h   Fuster, Valentín ^a,i   Yellon, Derek M ^d   Ibanez, Borja ^a,h  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Hospital Universitario HM Montepríncipe   (Spain)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^g Hospital Universitario Quiron   (Spain)

^h HOSPITAL CLÍNICO SAN CARLOS   (Spain)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Beta adrenergic receptor blocker; Ischemia reperfusion; Magnetic resonance imaging; Mitochondrial permeability transition pore; Myocardial infarction

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA ADRENERGIC RECEPTOR; CYCLOPHILIN D; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN KINASE B; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CARDIOTONIC AGENT; CARRIER PROTEIN; CYCLOPHILIN; ETHANOLAMINE DERIVATIVE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NITRIC OXIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; DRUG MECHANISM; ECHOCARDIOGRAPHY; HEART FUNCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPOXIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LONG TERM CARE; MALE; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGNOSIS; REOXYGENATION; REPERFUSION INJURY; SINGLE DRUG DOSE; THREE DIMENSIONAL IMAGING; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SWINE; TIME;

ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; CARDIOTONIC AGENTS; CELL DEATH; CYCLOPHILINS; DISEASE MODELS, ANIMAL; ETHANOLAMINES; MAGNETIC RESONANCE IMAGING; MALE; MICE, KNOCKOUT; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NITRIC OXIDE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION; SWINE; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 84902714796     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0422-0     Document Type: Article

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