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Volumn 2014, Issue , 2014, Pages

Mechanotransduction in musculoskeletal tissue regeneration: Effects of fluid flow, loading, and cellular-molecular pathways

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MICRORNA; WNT PROTEIN;

EID: 84907386597     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/863421     Document Type: Review
Times cited : (51)

References (98)
  • 1
    • 0142023090 scopus 로고    scopus 로고
    • Influence of muscle strength, physical activity and weight on bone mass in a population-based sample of 1004 elderly women
    • P. Gerdhem, K. A. M. Ringsberg, K. A˚kesson, and K. J. Obrant, "Influence of muscle strength, physical activity and weight on bone mass in a population-based sample of 1004 elderly women," Osteoporosis International, vol. 14, no. 9, pp. 768-772, 2003.
    • (2003) Osteoporosis International , vol.14 , Issue.9 , pp. 768-772
    • Gerdhem, P.1    Ringsberg, K.A.M.2    A˚kesson, K.3    Obrant, K.J.4
  • 2
    • 0037268828 scopus 로고    scopus 로고
    • Bonemass cannot be predicted by estimations of frailty in elderly ambulatorywomen
    • P. Gerdhem, K. A. M. Ringsberg, H. Magnusson, K. J. Obrant, and K. A˚kesson, "Bonemass cannot be predicted by estimations of frailty in elderly ambulatorywomen," Gerontology, vol. 49, no. 3, pp. 168-172, 2003.
    • (2003) Gerontology , vol.49 , Issue.3 , pp. 168-172
    • Gerdhem, P.1    Ringsberg, K.A.M.2    Magnusson, H.3    Obrant, K.J.4    A˚kesson, K.5
  • 3
    • 0033665996 scopus 로고    scopus 로고
    • Muscle volume, MRI relaxation times (T2), and body composition after spaceflight
    • A. LeBlanc, C. Lin, L. Shackelford et al., "Muscle volume, MRI relaxation times (T2), and body composition after spaceflight," Journal of Applied Physiology, vol. 89, no. 6, pp. 2158-2164, 2000.
    • (2000) Journal of Applied Physiology , vol.89 , Issue.6 , pp. 2158-2164
    • LeBlanc, A.1    Lin, C.2    Shackelford, L.3
  • 6
    • 0015990449 scopus 로고
    • Relations of the compressive properties of human cortical bone to histological structure and calcification
    • F. G. Evans and R. Vincentelli, "Relations of the compressive properties of human cortical bone to histological structure and calcification," Journal of Biomechanics, vol. 7, no. 1, pp. 1-10, 1974.
    • (1974) Journal of Biomechanics , vol.7 , Issue.1 , pp. 1-10
    • Evans, F.G.1    Vincentelli, R.2
  • 8
    • 0031431696 scopus 로고    scopus 로고
    • Analysis of symmetry of vertebral body loading consequent to lateral spinal curvature
    • I. A. Stokes, "Analysis of symmetry of vertebral body loading consequent to lateral spinal curvature," Spine, vol. 22, no. 21, pp. 2495-2503, 1997.
    • (1997) Spine , vol.22 , Issue.21 , pp. 2495-2503
    • Stokes, I.A.1
  • 11
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • C. T. Rubin and L. E. Lanyon, "Regulation of bone formation by applied dynamic loads," Journal of Bone and Joint Surgery A, vol. 66, no. 3, pp. 397-402, 1984.
    • (1984) Journal of Bone and Joint Surgery A , vol.66 , Issue.3 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 12
    • 0033105047 scopus 로고    scopus 로고
    • Site-specific skeletal effects of exercise: Importance of interstitial fluid pressure
    • C. H. Turner, "Site-specific skeletal effects of exercise: importance of interstitial fluid pressure," Bone, vol. 24, no. 3, pp. 161-162, 1999.
    • (1999) Bone , vol.24 , Issue.3 , pp. 161-162
    • Turner, C.H.1
  • 14
    • 0020678417 scopus 로고
    • Physical exercise as prophylaxis against involutional vertebral bone loss: A controlled trial
    • B. Krolner, B. Toft, S. P. Nielsen, and E. Tondevold, "Physical exercise as prophylaxis against involutional vertebral bone loss: a controlled trial," Clinical Science, vol. 64, no. 5, pp. 541-546, 1983.
    • (1983) Clinical Science , vol.64 , Issue.5 , pp. 541-546
    • Krolner, B.1    Toft, B.2    Nielsen, S.P.3    Tondevold, E.4
  • 16
    • 0033051667 scopus 로고    scopus 로고
    • Muscle blood flow during exercise: The limits of reductionism
    • M. J. Joyner and D. N. Proctor, "Muscle blood flow during exercise: the limits of reductionism," Medicine and Science in Sports and Exercise, vol. 31, no. 7, pp. 1036-1040, 1999.
    • (1999) Medicine and Science in Sports and Exercise , vol.31 , Issue.7 , pp. 1036-1040
    • Joyner, M.J.1    Proctor, D.N.2
  • 17
    • 17944363371 scopus 로고    scopus 로고
    • Blood pressure and exercise: Failing the acid test
    • M. J. Joyner, "Blood pressure and exercise: Failing the acid test," Journal of Physiology, vol. 537, no. 2, p. 331, 2001.
    • (2001) Journal of Physiology , vol.537 , Issue.2 , pp. 331
    • Joyner, M.J.1
  • 18
    • 0033238114 scopus 로고    scopus 로고
    • Tissue oxygenation by near-infrared spectroscopy and muscle blood flow during isometric contractions of the forearm
    • A. Hicks, S. McGill, and R. L. Hughson, "Tissue oxygenation by near-infrared spectroscopy and muscle blood flow during isometric contractions of the forearm," Canadian Journal of Applied Physiology, vol. 24, no. 3, pp. 216-230, 1999.
    • (1999) Canadian Journal of Applied Physiology , vol.24 , Issue.3 , pp. 216-230
    • Hicks, A.1    McGill, S.2    Hughson, R.L.3
  • 20
    • 0041381148 scopus 로고    scopus 로고
    • Microgravity and aging of animals
    • L. V. Serova, "Microgravity and aging of animals," Journal of Gravitational Physiology, vol. 8, no. 1, pp. P137-P138, 2001.
    • (2001) Journal of Gravitational Physiology , vol.8 , Issue.1 , pp. P137-P138
    • Serova, L.V.1
  • 21
    • 0011168616 scopus 로고    scopus 로고
    • Mechanisms ofmicrogravity induced orthostatic intolerance: Implications for effective countermeasures
    • V. A. Convertino, "Mechanisms ofmicrogravity induced orthostatic intolerance: implications for effective countermeasures," Journal of Gravitational Physiology, vol. 9, pp. 1-13, 2002.
    • (2002) Journal of Gravitational Physiology , vol.9 , pp. 1-13
    • Convertino, V.A.1
  • 22
    • 25144504860 scopus 로고    scopus 로고
    • The muscle pump: What question do we want to answer?
    • M. H. Laughlin, "The muscle pump: what question do we want to answer?" Journal of Applied Physiology, vol. 99, no. 2, p. 774, 2005.
    • (2005) Journal of Applied Physiology , vol.99 , Issue.2 , pp. 774
    • Laughlin, M.H.1
  • 23
    • 0032730093 scopus 로고    scopus 로고
    • Does bone perfusion/reperfusion initiate bone remodeling and the stress fracture syndrome?
    • M. W. Otter, Y. X. Qin, C. T. Rubin, and K. J. McLeod, "Does bone perfusion/reperfusion initiate bone remodeling and the stress fracture syndrome?" Medical Hypotheses, vol. 53, no. 5, pp. 363-368, 1999.
    • (1999) Medical Hypotheses , vol.53 , Issue.5 , pp. 363-368
    • Otter, M.W.1    Qin, Y.X.2    Rubin, C.T.3    McLeod, K.J.4
  • 24
    • 3042747954 scopus 로고    scopus 로고
    • A bone fluid flow hypothesis formuscle pump-driven capillary filtration: II Proposed role for exercise in erodible scaffold implant incorporation
    • H. Winet, B. Noble, and D. Jones, "A bone fluid flow hypothesis formuscle pump-driven capillary filtration: II Proposed role for exercise in erodible scaffold implant incorporation," European Cells and Materials, vol. 6, pp. 1-11, 2003.
    • (2003) European Cells and Materials , vol.6 , pp. 1-11
    • Winet, H.1    Noble, B.2    Jones, D.3
  • 25
    • 0023036458 scopus 로고
    • A unifying principle relating stress to trabecular bone morphology
    • D. P. Fyhrie and D. R. Carter, "A unifying principle relating stress to trabecular bone morphology," Journal of Orthopaedic Research, vol. 4, no. 3, pp. 304-317, 1986.
    • (1986) Journal of Orthopaedic Research , vol.4 , Issue.3 , pp. 304-317
    • Fyhrie, D.P.1    Carter, D.R.2
  • 28
    • 0028926506 scopus 로고
    • Morphologic stages in lamellar bone formation stimulated by a potent mechanical stimulus
    • C. T. Rubin, T. S. Gross, K. J. Mcleod, and S. D. Bain, "Morphologic stages in lamellar bone formation stimulated by a potent mechanical stimulus," Journal of Bone and Mineral Research, vol. 10, no. 3, pp. 488-495, 1995.
    • (1995) Journal of Bone and Mineral Research , vol.10 , Issue.3 , pp. 488-495
    • Rubin, C.T.1    Gross, T.S.2    Mcleod, K.J.3    Bain, S.D.4
  • 30
    • 0034109933 scopus 로고    scopus 로고
    • Increased distraction rates influence precursor tissue composition without affecting bone regeneration
    • M. Richards, K. M. Kozloff, J. A. Goulet, and S. A. Goldstein, "Increased distraction rates influence precursor tissue composition without affecting bone regeneration," Journal of Bone and Mineral Research, vol. 15, no. 5, pp. 982-989, 2000.
    • (2000) Journal of Bone and Mineral Research , vol.15 , Issue.5 , pp. 982-989
    • Richards, M.1    Kozloff, K.M.2    Goulet, J.A.3    Goldstein, S.A.4
  • 31
    • 0000636339 scopus 로고
    • Sensitivity of the bone remodeling response to the frequency of applied strain
    • K. McLeod and C. T. Rubin, "Sensitivity of the bone remodeling response to the frequency of applied strain," Transactions of the Orthopaedic Research Society, vol. 17, p. 533, 1992.
    • (1992) Transactions of the Orthopaedic Research Society , vol.17 , pp. 533
    • McLeod, K.1    Rubin, C.T.2
  • 32
    • 0032124595 scopus 로고    scopus 로고
    • Nonlinear dependence of loading intensity and cycle number in themaintenance of bonemass andmorphology
    • Y.-X. Qin, C. T. Rubin, and K. J. McLeod, "Nonlinear dependence of loading intensity and cycle number in themaintenance of bonemass andmorphology," Journal ofOrthopaedic Research, vol. 16, no. 4, pp. 482-489, 1998.
    • (1998) Journal OfOrthopaedic Research , vol.16 , Issue.4 , pp. 482-489
    • Qin, Y.-X.1    Rubin, C.T.2    McLeod, K.J.3
  • 33
    • 58149314041 scopus 로고    scopus 로고
    • Intramedullary pressure and matrix strain induced by oscillatory skeletalmuscle stimulation and its potential in adaptation
    • Y. Qin and H. Lam, "Intramedullary pressure and matrix strain induced by oscillatory skeletalmuscle stimulation and its potential in adaptation," Journal of Biomechanics, vol. 42, no. 2, pp. 140-145, 2009.
    • (2009) Journal of Biomechanics , vol.42 , Issue.2 , pp. 140-145
    • Qin, Y.1    Lam, H.2
  • 35
    • 0030804099 scopus 로고    scopus 로고
    • Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton
    • S. Judex, T. S. Gross, and R. F. Zernicke, "Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton," Journal of Bone andMineral Research, vol. 12, no. 10, pp. 1737-1745, 1997.
    • (1997) Journal of Bone AndMineral Research , vol.12 , Issue.10 , pp. 1737-1745
    • Judex, S.1    Gross, T.S.2    Zernicke, R.F.3
  • 36
    • 0033924276 scopus 로고    scopus 로고
    • High-impact exercise and growing bone: Relation between high strain rates and enhanced bone formation
    • S. Judex and R. F. Zernicke, "High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation," Journal of Applied Physiology, vol. 88, no. 6, pp. 2183-2191, 2000.
    • (2000) Journal of Applied Physiology , vol.88 , Issue.6 , pp. 2183-2191
    • Judex, S.1    Zernicke, R.F.2
  • 37
    • 0034896710 scopus 로고    scopus 로고
    • Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force
    • A. G. Robling, K. M. Duijvelaar, J. V. Geevers, N. Ohashi, and C. H. Turner, "Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force," Bone, vol. 29, no. 2, pp. 105-113, 2001.
    • (2001) Bone , vol.29 , Issue.2 , pp. 105-113
    • Robling, A.G.1    Duijvelaar, K.M.2    Geevers, J.V.3    Ohashi, N.4    Turner, C.H.5
  • 38
    • 0027952924 scopus 로고
    • Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain
    • C. T. Rubin and K. J. McLeod, "Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain," Clinical Orthopaedics and Related Research, no. 298, pp. 165-174, 1994.
    • (1994) Clinical Orthopaedics and Related Research , Issue.298 , pp. 165-174
    • Rubin, C.T.1    McLeod, K.J.2
  • 39
    • 0017654342 scopus 로고
    • Transport mechanism operating between blood supply and osteocytes in long bones
    • K. Piekarski and M. Munro, "Transport mechanism operating between blood supply and osteocytes in long bones," Nature, vol. 269, no. 5623, pp. 80-82, 1977.
    • (1977) Nature , vol.269 , Issue.5623 , pp. 80-82
    • Piekarski, K.1    Munro, M.2
  • 40
    • 0025359865 scopus 로고
    • Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
    • K. M. Reich, C. V. Gay, and J. A. Frangos, "Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production," Journal of Cellular Physiology, vol. 143, no. 1, pp. 100-104, 1990.
    • (1990) Journal of Cellular Physiology , vol.143 , Issue.1 , pp. 100-104
    • Reich, K.M.1    Gay, C.V.2    Frangos, J.A.3
  • 41
    • 0028024121 scopus 로고
    • Mechanotransduction in bone: Do bone cells act as sensors of fluid flow?
    • C. H. Turner, M. R. Forwood, and M. W. Otter, "Mechanotransduction in bone: do bone cells act as sensors of fluid flow?" The FASEB Journal, vol. 8, no. 11, pp. 875-878, 1994.
    • (1994) The FASEB Journal , vol.8 , Issue.11 , pp. 875-878
    • Turner, C.H.1    Forwood, M.R.2    Otter, M.W.3
  • 42
    • 0028386524 scopus 로고
    • A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
    • S. Weinbaum, S. C. Cowin, and Y. Zeng, "A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses," Journal of Biomechanics, vol. 27, no. 3, pp. 339-360, 1994.
    • (1994) Journal of Biomechanics , vol.27 , Issue.3 , pp. 339-360
    • Weinbaum, S.1    Cowin, S.C.2    Zeng, Y.3
  • 43
    • 0034975005 scopus 로고    scopus 로고
    • A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes
    • S. Weinbaum, P. Guo, and L. You, "A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes," Biorheology, vol. 38, no. 2-3, pp. 119-142, 2001.
    • (2001) Biorheology , vol.38 , Issue.2-3 , pp. 119-142
    • Weinbaum, S.1    Guo, P.2    You, L.3
  • 44
    • 0033804637 scopus 로고    scopus 로고
    • Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow
    • J. You, C. E. Yellowley, H. J. Donahue, Y. Zhang, Q. Chen, and C. R. Jacobs, "Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow," Journal of Biomechanical Engineering, vol. 122, no. 4, pp. 387-393, 2000.
    • (2000) Journal of Biomechanical Engineering , vol.122 , Issue.4 , pp. 387-393
    • You, J.1    Yellowley, C.E.2    Donahue, H.J.3    Zhang, Y.4    Chen, Q.5    Jacobs, C.R.6
  • 45
    • 0000915270 scopus 로고
    • Streaming potential in fluid filled bone
    • S. R. Pollack, R. Salzstein, and D. Pienkowski, "Streaming potential in fluid filled bone," Ferroelectrics, vol. 60, pp. 297-309, 1984.
    • (1984) Ferroelectrics , vol.60 , pp. 297-309
    • Pollack, S.R.1    Salzstein, R.2    Pienkowski, D.3
  • 47
    • 0023274180 scopus 로고
    • Electromechanical potentials in cortical bone: II. Experimental analysis
    • R. A. Salzstein and S. R. Pollack, "Electromechanical potentials in cortical bone: II. Experimental analysis," Journal of Biomechanics, vol. 20, no. 3, pp. 271-280, 1987.
    • (1987) Journal of Biomechanics , vol.20 , Issue.3 , pp. 271-280
    • Salzstein, R.A.1    Pollack, S.R.2
  • 48
    • 0034190391 scopus 로고    scopus 로고
    • Pressure-induced periprosthetic osteolysis: A rat model
    • R. Skripitz and P. Aspenberg, "Pressure-induced periprosthetic osteolysis: a rat model," Journal of Orthopaedic Research, vol. 18, no. 3, pp. 481-484, 2000.
    • (2000) Journal of Orthopaedic Research , vol.18 , Issue.3 , pp. 481-484
    • Skripitz, R.1    Aspenberg, P.2
  • 49
    • 0025335336 scopus 로고
    • Venous pressure and bone formation
    • P. J. Kelly and J. T. Bronk, "Venous pressure and bone formation," Microvascular Research, vol. 39, no. 3, pp. 364-375, 1990.
    • (1990) Microvascular Research , vol.39 , Issue.3 , pp. 364-375
    • Kelly, P.J.1    Bronk, J.T.2
  • 50
    • 0033105940 scopus 로고    scopus 로고
    • Femoral vein ligation increases bone mass in the hindlimb suspended rat
    • A. P. Bergula, W. Huang, and J. A. Frangos, "Femoral vein ligation increases bone mass in the hindlimb suspended rat," Bone, vol. 24, no. 3, pp. 171-177, 1999.
    • (1999) Bone , vol.24 , Issue.3 , pp. 171-177
    • Bergula, A.P.1    Huang, W.2    Frangos, J.A.3
  • 51
    • 84894112074 scopus 로고    scopus 로고
    • Dynamic fluid flow stimulation on cortical bone and alterations of the gene expressions of osteogenic growth factors and transcription factors in a rat functional disuse model
    • M. Hu and Y. X. Qin, "Dynamic fluid flow stimulation on cortical bone and alterations of the gene expressions of osteogenic growth factors and transcription factors in a rat functional disuse model," Archives of Biochemistry and Biophysics, vol. 545, pp. 154-161, 2014.
    • (2014) Archives of Biochemistry and Biophysics , vol.545 , pp. 154-161
    • Hu, M.1    Qin, Y.X.2
  • 52
    • 57049139887 scopus 로고    scopus 로고
    • The effects of frequency-dependent dynamic muscle stimulation on inhibition of trabecular bone loss in a disuse model
    • H. Lam and Y. Qin, "The effects of frequency-dependent dynamic muscle stimulation on inhibition of trabecular bone loss in a disuse model," Bone, vol. 43, no. 6, pp. 1093-1100, 2008.
    • (2008) Bone , vol.43 , Issue.6 , pp. 1093-1100
    • Lam, H.1    Qin, Y.2
  • 54
  • 55
    • 79954503362 scopus 로고    scopus 로고
    • Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia
    • S. L. Ferreri, R. Talish, T. Trandafir, and Y. Qin, "Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia," Bone, vol. 48, no. 5, pp. 1095-1102, 2011.
    • (2011) Bone , vol.48 , Issue.5 , pp. 1095-1102
    • Ferreri, S.L.1    Talish, R.2    Trandafir, T.3    Qin, Y.4
  • 56
    • 84865622400 scopus 로고    scopus 로고
    • Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model
    • M. Hu, J. Cheng, and Y. X. Qin, "Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model," Bone, vol. 51, no. 4, 2012.
    • (2012) Bone , vol.51 , Issue.4
    • Hu, M.1    Cheng, J.2    Qin, Y.X.3
  • 57
    • 0034977855 scopus 로고    scopus 로고
    • Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance
    • J. E. Sherry, K. M. Oehrlein, K. S. Hegge, and B. J. Morgan, "Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance," Physical Therapy, vol. 81, no. 6, pp. 1183-1191, 2001.
    • (2001) Physical Therapy , vol.81 , Issue.6 , pp. 1183-1191
    • Sherry, J.E.1    Oehrlein, K.M.2    Hegge, K.S.3    Morgan, B.J.4
  • 58
    • 0742319021 scopus 로고    scopus 로고
    • Neuromuscular electrical stimulation enhances fracture healing: Results of an animal model
    • S. Park and M. Silva, "Neuromuscular electrical stimulation enhances fracture healing: results of an animal model," Journal of Orthopaedic Research, vol. 22, no. 2, pp. 382-387, 2004.
    • (2004) Journal of Orthopaedic Research , vol.22 , Issue.2 , pp. 382-387
    • Park, S.1    Silva, M.2
  • 59
    • 65249105399 scopus 로고    scopus 로고
    • Skeletal muscle contractions uncoupled from gravitational loading directly increase cortical bone blood flow rates in vivo
    • C. Caulkins, E. Ebramzadeh, and H. Winet, "Skeletal muscle contractions uncoupled from gravitational loading directly increase cortical bone blood flow rates in vivo," Journal of Orthopaedic Research, vol. 27, no. 5, pp. 651-656, 2009.
    • (2009) Journal of Orthopaedic Research , vol.27 , Issue.5 , pp. 651-656
    • Caulkins, C.1    Ebramzadeh, E.2    Winet, H.3
  • 60
    • 84895922168 scopus 로고    scopus 로고
    • Coupling the activities of bone formation and resorption: A multitude of signals within the basic multicellular unit
    • N. A. Sims and T. J. Martin, "Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit," BoneKEy Reports, vol. 3, article 481, 2014.
    • (2014) BoneKEy Reports , vol.3
    • Sims, N.A.1    Martin, T.J.2
  • 61
    • 77955497814 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of bone remodeling
    • L. J. Raggatt and N. C. Partridge, "Cellular and molecular mechanisms of bone remodeling," Journal of Biological Chemistry, vol. 285, no. 33, pp. 25103-25108, 2010.
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.33 , pp. 25103-25108
    • Raggatt, L.J.1    Partridge, N.C.2
  • 62
    • 0036125374 scopus 로고    scopus 로고
    • Osteocytes: A proposed multifunctional bone cell
    • L. F. Bonewald, "Osteocytes: a proposed multifunctional bone cell," Journal ofMusculoskeletal Neuronal Interactions, vol. 2, no. 3, pp. 239-241, 2002.
    • (2002) Journal OfMusculoskeletal Neuronal Interactions , vol.2 , Issue.3 , pp. 239-241
    • Bonewald, L.F.1
  • 64
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • L. F. Bonewald and M. L. Johnson, "Osteocytes, mechanosensing and Wnt signaling," Bone, vol. 42, no. 4, pp. 606-615, 2008.
    • (2008) Bone , vol.42 , Issue.4 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 65
    • 34547111836 scopus 로고    scopus 로고
    • Wnt/betacatenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor α
    • V. J. Armstrong, M. Muzylak, A. Sunters et al., "Wnt/betacatenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor α," Journal of Biological Chemistry, vol. 282, no. 28, pp. 20715-20727, 2007.
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.28 , pp. 20715-20727
    • Armstrong, V.J.1    Muzylak, M.2    Sunters, A.3
  • 66
    • 33846026749 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    • J. A. Robinson, M. Chatterjee-Kishore, P. J. Yaworsky et al., "Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone," Journal of Biological Chemistry, vol. 281, no. 42, pp. 31720-31728, 2006.
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.42 , pp. 31720-31728
    • Robinson, J.A.1    Chatterjee-Kishore, M.2    Yaworsky, P.J.3
  • 67
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and dickkopf-1 as therapeutic targets in bone diseases
    • H. Z. Ke, W. G. Richards, X. Li, and M. S. Ominsky, "Sclerostin and dickkopf-1 as therapeutic targets in bone diseases," Endocrine Reviews, vol. 33, no. 5, pp. 747-783, 2012.
    • (2012) Endocrine Reviews , vol.33 , Issue.5 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3    Ominsky, M.S.4
  • 68
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • X. Li, Y. Zhang, H. Kang et al., "Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling," Journal of Biological Chemistry, vol. 280, no. 20, pp. 19883-19887, 2005.
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.20 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3
  • 69
    • 25144448701 scopus 로고    scopus 로고
    • Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
    • X. Li, P. Liu, W. Liu et al., "Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation," Nature Genetics, vol. 37, no. 9, pp. 945-952, 2005.
    • (2005) Nature Genetics , vol.37 , Issue.9 , pp. 945-952
    • Li, X.1    Liu, P.2    Liu, W.3
  • 70
    • 75149150013 scopus 로고    scopus 로고
    • Mechanical signals as anabolic agents in bone
    • E. Ozcivici, Y. K. Luu, B. Adler et al., "Mechanical signals as anabolic agents in bone," Nature Reviews Rheumatology, vol. 6, no. 1, pp. 50-59, 2010.
    • (2010) Nature Reviews Rheumatology , vol.6 , Issue.1 , pp. 50-59
    • Ozcivici, E.1    Luu, Y.K.2    Adler, B.3
  • 71
    • 36749045201 scopus 로고    scopus 로고
    • Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals
    • C. T. Rubin, E. Capilla, Y. K. Luu et al., "Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 45, pp. 17879-17884, 2007.
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.45 , pp. 17879-17884
    • Rubin, C.T.1    Capilla, E.2    Luu, Y.K.3
  • 72
    • 58149084456 scopus 로고    scopus 로고
    • Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity
    • Y. K. Luu, E. Capilla, C. J. Rosen et al., "Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity," Journal of Bone and Mineral Research, vol. 24, no. 1, pp. 50-61, 2009.
    • (2009) Journal of Bone and Mineral Research , vol.24 , Issue.1 , pp. 50-61
    • Luu, Y.K.1    Capilla, E.2    Rosen, C.J.3
  • 73
    • 80051982519 scopus 로고    scopus 로고
    • Mechanical signals as a non-invasive means to influence mesenchymal stem cell fate, promoting bone and suppressing the fat phenotype
    • Y. K. Luu, J. E. Pessin, S. Judex, J. Rubin, and C. T. Rubin, "Mechanical signals as a non-invasive means to influence mesenchymal stem cell fate, promoting bone and suppressing the fat phenotype," BoneKEy Osteovision, vol. 6, no. 4, pp. 132-149, 2009.
    • (2009) BoneKEy Osteovision , vol.6 , Issue.4 , pp. 132-149
    • Luu, Y.K.1    Pessin, J.E.2    Judex, S.3    Rubin, J.4    Rubin, C.T.5
  • 74
    • 21044441395 scopus 로고    scopus 로고
    • Distinct effects of PPARγ insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells
    • H. Kawaguchi, T. Akune, M. Yamaguchi et al., "Distinct effects of PPARγ insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells," Journal of Bone and Mineral Metabolism, vol. 23, no. 4, pp. 275-279, 2005.
    • (2005) Journal of Bone and Mineral Metabolism , vol.23 , Issue.4 , pp. 275-279
    • Kawaguchi, H.1    Akune, T.2    Yamaguchi, M.3
  • 75
    • 84862923506 scopus 로고    scopus 로고
    • A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density
    • J. Liu, N. Hoppman, J. R. O'Connell et al., "A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density," Journal of Bone and Mineral Research, vol. 27, no. 2, pp. 331-341, 2012.
    • (2012) Journal of Bone and Mineral Research , vol.27 , Issue.2 , pp. 331-341
    • Liu, J.1    Hoppman, N.2    O'Connell, J.R.3
  • 76
    • 67650272844 scopus 로고    scopus 로고
    • Fatmass is negatively associated with cortical bone size in young healthy male siblings
    • Y. E. C. Taes, B. Lapauw, G. Vanbillemont et al., "Fatmass is negatively associated with cortical bone size in young healthy male siblings," Journal of Clinical Endocrinology andMetabolism, vol. 94, no. 7, pp. 2325-2331, 2009.
    • (2009) Journal of Clinical Endocrinology AndMetabolism , vol.94 , Issue.7 , pp. 2325-2331
    • Taes, Y.E.C.1    Lapauw, B.2    Vanbillemont, G.3
  • 77
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-relatedprotein 5 (LRP5) affects bone accrual and eye development
    • Y. Gong, R. B. Slee, N. Fukai et al., "LDL receptor-relatedprotein 5 (LRP5) affects bone accrual and eye development," Cell, vol. 107, no. 4, pp. 513-523, 2001.
    • (2001) Cell , vol.107 , Issue.4 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 78
    • 0036862205 scopus 로고    scopus 로고
    • Mechanotransduction in bone: Genetic effects onmechanosensitivity in mice
    • A. G. Robling and C. H. Turner, "Mechanotransduction in bone: genetic effects onmechanosensitivity in mice," Bone, vol. 31, no. 5, pp. 562-569, 2002.
    • (2002) Bone , vol.31 , Issue.5 , pp. 562-569
    • Robling, A.G.1    Turner, C.H.2
  • 80
    • 33747674263 scopus 로고    scopus 로고
    • The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
    • K. Sawakami, A. G. Robling, M. Ai et al., "The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment," The Journal of Biological Chemistry, vol. 281, no. 33, pp. 23698-23711, 2006.
    • (2006) The Journal of Biological Chemistry , vol.281 , Issue.33 , pp. 23698-23711
    • Sawakami, K.1    Robling, A.G.2    Ai, M.3
  • 81
    • 77955567263 scopus 로고    scopus 로고
    • Insights from the conduct of a device trial in older persons: Low magnitude mechanical stimulation for musculoskeletal health
    • D. P. Kiel, M. T. Hannan, B. A. Barton et al., "Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health," Clinical Trials, vol. 7, no. 4, pp. 354-367, 2010.
    • (2010) Clinical Trials , vol.7 , Issue.4 , pp. 354-367
    • Kiel, D.P.1    Hannan, M.T.2    Barton, B.A.3
  • 82
    • 0036138175 scopus 로고    scopus 로고
    • Amutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • R.D. Little, J. P. Carulli, R. G.Del Mastro et al., "Amutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait," American Journal of Human Genetics, vol. 70, no. 1, pp. 11-19, 2002.
    • (2002) American Journal of Human Genetics , vol.70 , Issue.1 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3
  • 83
    • 84864772292 scopus 로고    scopus 로고
    • Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner
    • P. J. Niziolek, M. L. Warman, and A. G. Robling, "Mechanotransduction in bone tissue: the A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner," Bone, vol. 51, no. 3, pp. 459-465, 2012.
    • (2012) Bone , vol.51 , Issue.3 , pp. 459-465
    • Niziolek, P.J.1    Warman, M.L.2    Robling, A.G.3
  • 84
    • 84875747127 scopus 로고    scopus 로고
    • Comparisonof the biological response of osteoblasts after tension and compression
    • Z. Zhong, X. Zeng, J. Ni, and X. Huang, "Comparisonof the biological response of osteoblasts after tension and compression," European Journal of Orthodontics, vol. 35, no. 1, pp. 59-65, 2013.
    • (2013) European Journal of Orthodontics , vol.35 , Issue.1 , pp. 59-65
    • Zhong, Z.1    Zeng, X.2    Ni, J.3    Huang, X.4
  • 85
    • 84878252664 scopus 로고    scopus 로고
    • Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts
    • T. S. Lisse, R. F. Chun, S. Rieger, J. S. Adams, and M. Hewison, "Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts," Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1478-1488, 2013.
    • (2013) Journal of Bone and Mineral Research , vol.28 , Issue.6 , pp. 1478-1488
    • Lisse, T.S.1    Chun, R.F.2    Rieger, S.3    Adams, J.S.4    Hewison, M.5
  • 86
    • 84876461818 scopus 로고    scopus 로고
    • Systemic administration of an antagomir designed to inhibit mir-92, a regulator of angiogenesis, failed to modulate skeletal anabolic response to mechanical loading
    • A. Sengul, R. Santisuk, W. Xing, and C. Kesavan, "Systemic administration of an antagomir designed to inhibit mir-92, a regulator of angiogenesis, failed to modulate skeletal anabolic response to mechanical loading," Physiological Research, vol. 62, no. 2, pp. 221-226, 2013.
    • (2013) Physiological Research , vol.62 , Issue.2 , pp. 221-226
    • Sengul, A.1    Santisuk, R.2    Xing, W.3    Kesavan, C.4
  • 87
    • 84862777464 scopus 로고    scopus 로고
    • MicroRNA control of bone formation and homeostasis
    • J. B. Lian, G. S. Stein, A. J. van Wijnen et al., "MicroRNA control of bone formation and homeostasis," Nature Reviews Endocrinology, vol. 8, no. 4, pp. 212-227, 2012.
    • (2012) Nature Reviews Endocrinology , vol.8 , Issue.4 , pp. 212-227
    • Lian, J.B.1    Stein, G.S.2    Van Wijnen, A.J.3
  • 88
    • 38549101581 scopus 로고    scopus 로고
    • Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor
    • E. Luzi, F. Marini, S. C. Sala, I. Tognarini, G. Galli, and M. L. Brandi, "Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor," Journal of Bone and Mineral Research, vol. 23, no. 2, pp. 287-295, 2008.
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.2 , pp. 287-295
    • Luzi, E.1    Marini, F.2    Sala, S.C.3    Tognarini, I.4    Galli, G.5    Brandi, M.L.6
  • 89
    • 69249143283 scopus 로고    scopus 로고
    • miR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling
    • K. Kapinas, C. B. Kessler, and A. M. Delany, "miR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling," Journal of Cellular Biochemistry, vol. 108, no. 1, pp. 216-224, 2009.
    • (2009) Journal of Cellular Biochemistry , vol.108 , Issue.1 , pp. 216-224
    • Kapinas, K.1    Kessler, C.B.2    Delany, A.M.3
  • 90
    • 39549105164 scopus 로고    scopus 로고
    • miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation
    • Y. Mizuno, K. Yagi, Y. Tokuzawa et al., "miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation," Biochemical and Biophysical Research Communications, vol. 368, no. 2, pp. 267-272, 2008.
    • (2008) Biochemical and Biophysical Research Communications , vol.368 , Issue.2 , pp. 267-272
    • Mizuno, Y.1    Yagi, K.2    Tokuzawa, Y.3
  • 91
    • 84872687459 scopus 로고    scopus 로고
    • MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by coregulating BMP signaling
    • J. Zhang, W. Fu, M. He et al., "MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by coregulating BMP signaling," RNA Biology, vol. 8, no. 5, pp. 829-838, 2011.
    • (2011) RNA Biology , vol.8 , Issue.5 , pp. 829-838
    • Zhang, J.1    Fu, W.2    He, M.3
  • 93
    • 0034905007 scopus 로고    scopus 로고
    • Biomaterials and bone mechanotransduction
    • V. I. Sikavitsas, J. S. Temenoff, and A. G. Mikos, "Biomaterials and bone mechanotransduction," Biomaterials, vol. 22, no. 19, pp. 2581-2593, 2001.
    • (2001) Biomaterials , vol.22 , Issue.19 , pp. 2581-2593
    • Sikavitsas, V.I.1    Temenoff, J.S.2    Mikos, A.G.3
  • 94
    • 79952628636 scopus 로고    scopus 로고
    • Low-intensity amplitude modulated ultrasound increases osteoblastic mineralization
    • S. M. Z. Uddin, J. Cheng, W. Lin, and Y. Qin, "Low-intensity amplitude modulated ultrasound increases osteoblastic mineralization," Cellular and Molecular Bioengineering, vol. 4, no. 1, pp. 81-90, 2011.
    • (2011) Cellular and Molecular Bioengineering , vol.4 , Issue.1 , pp. 81-90
    • Uddin, S.M.Z.1    Cheng, J.2    Lin, W.3    Qin, Y.4
  • 96
    • 2442477849 scopus 로고    scopus 로고
    • Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro
    • J. R. Mauney, S. Sjostorm, J. Blumberg et al., "Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro," Calcified Tissue International, vol. 74, no. 5, pp. 458-468, 2004.
    • (2004) Calcified Tissue International , vol.74 , Issue.5 , pp. 458-468
    • Mauney, J.R.1    Sjostorm, S.2    Blumberg, J.3
  • 97
    • 67649884736 scopus 로고    scopus 로고
    • Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold
    • J. Milan, J. A. Planell, and D. Lacroix, "Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold," Biomaterials, vol. 30, no. 25, pp. 4219-4226, 2009.
    • (2009) Biomaterials , vol.30 , Issue.25 , pp. 4219-4226
    • Milan, J.1    Planell, J.A.2    Lacroix, D.3
  • 98
    • 79959933094 scopus 로고    scopus 로고
    • Biomechanics and tissue engineering
    • D. P. Pioletti, "Biomechanics and tissue engineering," Osteoporosis International, vol. 22, no. 6, pp. 2027-2031, 2011.
    • (2011) Osteoporosis International , vol.22 , Issue.6 , pp. 2027-2031
    • Pioletti, D.P.1


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