Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice

Experimental Gerontology

Volumn 58, Issue , 2014, Pages 146-153

  Takahashi, Kazuhide ^a   Noda, Yoshihiro ^a   Ohsawa, Ikuroh ^a   Shirasawa, Takuji ^b   Takahashi, Mayumi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Clk 1; Coenzyme Q; Leg skeletal muscles; Lifespan; Mitochondrial function; Oxygen consumption

Indexed keywords

ADENOSINE TRIPHOSPHATE; UBIQUINONE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIDECARENONE; CLK DUAL-SPECIFICITY KINASES; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY SIZE; CELL FUNCTION; CLK 1 GENE; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY YIELD; FEMALE; GENE; GENE EXPRESSION; LEG MUSCLE; LETHALITY; LIFE EXTENSION; MALE; MITOCHONDRION; MOUSE; MUSCLE MASS; MUSCLE METABOLISM; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; SKELETAL MUSCLE; TRANSGENIC MOUSE; BODY MASS; BODY WEIGHT; DARKNESS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXTENSOR DIGITORUM LONGUS MUSCLE; GASTROCNEMIUS MUSCLE; LIFESPAN; LIVER WEIGHT; LONGEVITY; MITOCHONDRIAL RESPIRATION; MUSCLE MITOCHONDRION; QUADRICEPS FEMORIS MUSCLE; SOLEUS MUSCLE; SURVIVAL RATE; TIBIALIS ANTERIOR MUSCLE; WILD TYPE; AGE; ANIMAL; C57BL MOUSE; ENERGY METABOLISM; ENZYMOLOGY; GENETICS; GENOTYPE; METABOLISM; ORGAN SIZE; PHENOTYPE;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ANIMALS; BODY SIZE; ENERGY METABOLISM; FEMALE; GENOTYPE; LONGEVITY; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, MUSCLE; ORGAN SIZE; OXYGEN CONSUMPTION; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; QUADRICEPS MUSCLE; UBIQUINONE;

EID: 84907377932     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.08.003     Document Type: Article

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