Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity

Cardiovascular Research

Volumn 103, Issue 4, 2014, Pages 629-640

  Walton, Richard D ^a,b   Martinez, Marine E ^a,b   Bishop, Martin J ^c   Hocini, Mélèze ^a,b,d   Haïssaguerre, Michel ^a,b,d   Plank, Gernot ^e   Bernus, Olivier ^a,b   Vigmond, Edward J ^a,f  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CENTRE DE RECHERCHE CARDIO THORACIQUE DE BORDEAUX   (France)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d HAUT LÉVÊQUE HOSPITAL   (France)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f UNIVERSITY OF CALGARY   (Canada)

Author keywords

Conduction system; Optical mapping; Purkinje muscle junction; Repolarization; Transmural heterogeneity

Indexed keywords

ACTION POTENTIAL DURATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOCARDIUM; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE; HEART REPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER MEMBRANE POTENTIAL; PURKINJE MUSCLE JUNCTION; SHEEP; STIMULATION; CELL HETEROGENEITY; CELL JUNCTION; CELL STRUCTURE; EXPERIMENTAL SHEEP; HEART MUSCLE CELL; PURKINJE FIBER; SURFACE PROPERTY; ACTION POTENTIAL; ANIMAL; HEART VENTRICLE; HUMAN; IMAGE PROCESSING; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PURKINJE CELL;

ACTION POTENTIALS; ANIMALS; ENDOCARDIUM; HEART FAILURE; HEART VENTRICLES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MYOCARDIUM; PURKINJE CELLS; SHEEP;

EID: 84907344249     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu165     Document Type: Article

References (37)

1. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, LiuDW. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 1991;69: 1427-1449.
2. Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev 2005; 85: 1205-1253.
3. Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, KalishPW, Schuessler RB, Moazami N, Efimov IR. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 2010;106: 981-991.
4. Antzelevitch C, Fish J. Electrical heterogeneity within the ventricular wall. Basic Res Cardiol 2001;96: 517-527.
5. Rouzioux JM. Who is responsible for what? Fundam Clin Pharmacol 1990;4(Suppl 2): 183s-187s.
6. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res 1991;68: 1729-1741.
7. Scubon-Mulieri B, Sichel FJ. Intracellular resistance and conduction in bullfrog atrium. Physiol Chem Phys 1975;7: 541-554.
8. Walton RD, Benson AP, Hardy ME, White E, Bernus O. Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence. Front Physiol 2013;4: 281.
9. Mendez C, MuellerWJ, Merideth J, Moe GK. Interaction of transmembrane potentials in canine Purkinje fibers and at Purkinje fiber-muscle junctions. Circ Res 1969;24: 361-372.
10. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation 1998;98: 1921-1927.
11. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998;98: 1928-1936.
12. ten Tusscher KH, Noble D, Noble PJ, PanfilovAV. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 2004;286: H1573-H1589.
13. Antzelevitch C, Shimizu W, Yan GX, Sicouri S. Cellular basis for QT dispersion. J Electrocardiol 1998;30(Suppl): 168-175.
14. Tranum-Jensen J, Wilde AA, Vermeulen JT, Janse MJ. Morphology of electrophysiologically identified junctions between Purkinje fibers and ventricular muscle in rabbit and pig hearts. Circ Res 1991;69: 429-437.
15. Boyle PM, Masse S, Nanthakumar K, Vigmond EJ. Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: mechanistic insights from rabbit ventricular models. Heart Rhythm 2013;10: 1710-1717.
16. Deo M, Boyle P, Plank G, Vigmond E. Arrhythmogenic mechanisms of the Purkinje system during electric shocks: a modeling study. Heart Rhythm 2009;6: 1782-1789.
17. Zamiri N, Masse S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PF, Vigmond EJ, Boyle PM, Behradfar E, Al-Hesayen A, Waxman MB, Backx P, Dorian P, Nanthakumar K. Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models. Circulation 2014;129: 875-885.
18. Vigmond EJ, Hughes M, Plank G, Leon LJ. Computational tools for modeling electrical activity in cardiac tissue. J Electrocardiol 2003;36(Suppl): 69-74.
19. Boyle PM, Deo M, Plank G, Vigmond EJ. Purkinje-mediated effects in the response of quiescent ventricles to defibrillation shocks. Ann Biomed Eng 2010;38: 456-468.
20. Walton RD, Smith RM, Mitrea BG, White E, Bernus O, Pertsov AM. Extracting surface activation time from the optically recorded action potential in three-dimensional myocardium. Biophys J 2012;102: 30-38.
21. Sheu SS, Korth M, Lathrop DA, Fozzard HA. Intra- and extracellular K+ and Na+ activities and resting membrane potential in sheep cardiac purkinje strands. Circ Res 1980;47: 692-700.
22. Boyden PA, Albala A, Dresdner KP Jr. Electrophysiology and ultrastructure of canine subendocardial Purkinje cells isolated from control and 24-hour infarcted hearts. Circ Res 1989;65: 955-970.
23. Robinson RB, Boyden PA, Hoffman BF, Hewett KW. Electrical restitution process in dispersed canine cardiac Purkinje and ventricular cells. Am J Physiol 1987;253: H1018-H1025.
24. Martinez-Palomo A, Alanis J, Benitez D. Transitional cardiac cells of the conductive system of the dog heart. Distinguishing morphological and electrophysiological features. J Cell Biol 1970;47: 1-17.
25. Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 2008;80: 9-19.
26. Shimada T, Nakamura M, Notohara A. The Purkinje fiber-myocardial cell region in the goat heart as studied by combined scanning electron microscopy and chemical digestion. Experientia 1984;40: 849-850.
27. Wiedmann RT, Tan RC, Joyner RW. Discontinuous conduction at Purkinje-ventricular muscle junction. Am J Physiol 1996;271: H1507-H1516.
28. Veenstra RD, Joyner RW, Rawling DA. Purkinje and ventricular activation sequences of canine papillary muscle. Effects of quinidine and calcium on the Purkinje-ventricular conduction delay. Circ Res 1984;54: 500-515.
29. Myerburg RJ, StewartJW, Hoffman BF. Electrophysiological properties of the canine peripheral A-V conducting system. Circ Res 1970;26: 361-378.
30. Tribulova N, Novakova S, Macsaliova A, Sass S, Thomas S, Goetzfried S, Podzuweit T, Manoach M. Histochemical and ultrastructural characterisation of an arrhythmogenic substrate in ischemic pig heart. Acta Histochem 2002;104: 393-397.
31. Huelsing DJ, SpitzerKW, Cordeiro JM, Pollard AE. Modulation of repolarization in rabbit Purkinje and ventricular myocytes coupled by a variable resistance.Am J Physiol 1999;276: H572-H581.
32. Zaniboni M, Pollard AE, Yang L, Spitzer KW. Beat-to-beat repolarization variability in ventricular myocytes and its suppression by electrical coupling. Am J Physiol Heart Circ Physiol 2000;278: H677-H687.
33. Janse MJ, Coronel R, Opthof T, Sosunov EA, Anyukhovsky EP, Rosen MR. Repolarization gradients inthe intact heart: transmuralorapico-basal? Prog BiophysMolBiol2012;109: 6-15.
34. Balati B, Varro A, Papp JG. Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium, M cells, endocardium and Purkinje fibres. Acta Physiol Scand 1998;164: 181-190.
35. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res 2003;93: 638-645.
36. Verkerk AO, Schumacher CA, van Ginneken AC, VeldkampMW, Ravesloot JH. Role of Ca(2+)-activated Cl(2) current in ventricular action potentials of sheep during adrenoceptor stimulation. Exp Physiol 2001;86: 151-159.
37. HanW, Chartier D, Li D, Nattel S. Ionic remodeling of cardiac Purkinje cells by congestive heart failure. Circulation 2001;104: 2095-2100.