Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: Mechanistic insights from rabbit ventricular models

Heart Rhythm

Volumn 10, Issue 11, 2013, Pages 1710-1717

  Boyle, Patrick M ^a,b   Massé, Stéphane ^c   Nanthakumar, Kumaraswamy ^c   Vigmond, Edward J ^a,d  

^a UNIVERSITY OF CALGARY   (Canada)

^b Johns Hopkins University   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Activation rate; ATP sensitive potassium current; Purkinje system; Transmural heterogeneity; Ventricular fibrillation

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE;

ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CARDIOVASCULAR PARAMETERS; COMPUTER SIMULATION; CONTROLLED STUDY; ENDOCARDIUM; EPICARDIUM; EXPERIMENTAL RABBIT; GENE EXPRESSION; GENETIC HETEROGENEITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE WALL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE FIBER; TRANSMURAL ACTIVATION RATE GRADIENT; ACTION POTENTIAL; ANIMAL; ELECTROCARDIOGRAPHY; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBITS AND HARES;

ACTION POTENTIAL DURATION; ACTIVATION RATE; ACTIVATION RATE GRADIENT; ADENOSINE TRIPHOSPHATE; APD; AR; ATP; ATP-SENSITIVE POTASSIUM CURRENT; ECG; ELECTROCARDIOGRAM; EXTRACELLULAR POTASSIUM CONCENTRATION; F(ATP); FRACTION OF CHANNELS IN THE ACTIVE STATE; I(K(ATP)); PMJ; PS; PURKINJE SYSTEM; PURKINJE-MYOCARDIAL JUNCTION; TRANSMEMBRANE VOLTAGE; TRANSMURAL HETEROGENEITY; V(M); VENTRICULAR FIBRILLATION; VF; [K(+)](E); ΔAR;

ACTION POTENTIALS; ANIMALS; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; KATP CHANNELS; RABBITS; VENTRICULAR FIBRILLATION;

MLCS; MLOWN;

EID: 84886997852     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.08.010     Document Type: Article

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