Effects of cocaine on the hypothalamic-pituitary-adrenal axis

Journal of Endocrinological Investigation

Volumn 37, Issue 8, 2014, Pages 701-708

  Manetti, L ^a   Cavagnini, F ^b   Martino, E ^a   Ambrogio, A ^b  

^a UNIVERSITY OF PISA   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

ACTH; Cocaine; Cortisol; HPA axis

Indexed keywords

CANNABIS; COCAINE; CENTRAL STIMULANT AGENT; HYDROCORTISONE; PSYCHOTROPIC AGENT; STREET DRUG;

ANIMAL MODEL; ANIMAL TISSUE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG ABUSE; ENDOCRINE SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NONHUMAN; PATHOPHYSIOLOGY; RAT; REINFORCEMENT; SHORT SURVEY; SYSTEMATIC REVIEW; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NERVE CELL; SECRETION (PROCESS); UPREGULATION;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, BIOLOGICAL; NEURONS; PITUITARY-ADRENAL SYSTEM; PSYCHOTROPIC DRUGS; STREET DRUGS; UP-REGULATION;

EID: 84907334911     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0091-8     Document Type: Short Survey

References (79)

1. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2012). Trend report for the evaluation of the 2005-12 EU drugs strategy. EMCDDA, Lisbon
2. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2013). European Drug Report 2013: Trends and developments. EMCDDA
3. Cone EJ (1995) Pharmacokinetics and pharmacodynamics of cocaine. J Anal Toxicol 19:459-478
4. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2013). Perspective on drugs: Emergency health consequences of cocaine use in Europe
5. Piazza PV, Le Moal M (1998) The role of stress in drug self-administration. Trends Pharmacol Sci 19:67-74
6. Koob GF (1999) Stress, corticotropin-releasing factor, and drug addiction. Ann N Y Acad Sci 897:27-45
7. Goeders NE (2002) The HPA axis and cocaine reinforcement. Psychoneuroendocrinology 27:13-33
8. Johnson EO, Kamilaris TC, Calogero AE, Konstandi M, Chrousos GP (2013) Effects of short- and long-duration hypothyroidism on function of the rat hypothalamic-pituitary-adrenal axis. J Endocrinol Invest 36:104-110
9. Moldow RL, Fischman AJ (1987) Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone. Peptides 8:819-822
10. Rivier C, Vale W (1987) Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism. Brain Res 422:403-406 (Pubitemid 18024051)
11. Borowsky B, Kuhn CM (1991) Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation. J Pharmacol Exp Ther 256:204-210
12. Levy AD, Li QA, Kerr JE et al (1991) Cocaine-induced elevation of plasma adrenocorticotropin hormone and corticosterone is mediated by serotonergic neurons. J Pharmacol Exp Ther 259:495-500
13. Sarnyai Z, Biro E, Penke B, Telegdy G (1992) The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing factor (CRF) in rats. Brain Res 589:154-156
14. Sarnyai Z, Biro E, Telegdy G (1993) Cocaine-induced elevation of plasma corticosterone is mediated by different neurotransmitter systems in rats. Pharmacol Biochem Behav 45:209-214
15. Schmidt ED, Tilders FJ, Janszen AW, Binnekade R, De Vries TJ, Schoffelmeer AN (1995) Intermittent cocaine exposure causes delayed and long-lasting sensitization of cocaine-induced ACTH secretion in rats. Eur J Pharmacol 285:317-321
16. Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164:1149-1159 (Pubitemid 47292402)
17. Sarnyai Z, Vecsernyes M, Laczi F, Biro E, Szabo G, Kovacs GL (1992) Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats. Neuropeptides 23:27-31
18. Rivier C, Lee S (1994) Stimulatory effect of cocaine on ACTH secretion: role of the hypothalamus. Mol Cell Neurosci 5:189-195 (Pubitemid 24118424)
19. Zhou Y, Litvin Y, Piras AP, Pfaff DW, Kreek MJ (2011) Persistent increase in hypothalamic arginine vasopressin gene expression during protracted withdrawal from chronic escalating-dose cocaine in rodents. Neuropsychopharmacology 36:2062-2075
20. Calogero AE, Gallucci WT, Kling MA, Chrousos GP, Gold PW (1989) Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain Res 505:7-11 (Pubitemid 20011104)
21. Ago Y, Nakamura S, Baba A, Matsuda T (2008) Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine and cocaine-induced behavioral sensitization in mice. J Pharmacol Sci 106:15-21 (Pubitemid 351159064)
22. Goeders NE (1997) A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 22:237-259
23. Goeders NE (2002) Stress and cocaine addiction. J Pharmacol Exp Ther 301:785-789
24. Haleem DJ, Kennett G, Curzon G (1988) Adaptation of female rats to stress: shift to male pattern by inhibition of corticosterone synthesis. Brain Res 458:339-347
25. Goeders NE, Guerin GF (1996) Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats. Brain Res 722:145-152
26. Iranmanesh A, Lizarralde G, Short D, Veldhuis JD (1990) Intensive venous sampling paradigms disclose high frequency adrenocorticotropin release episodes in normal men. J Clin Endocrinol Metab 71:1276-1283
27. Carnes M, Kalin NH, Lent SJ, Barksdale CM, Brownfield MS (1988) Pulsatile ACTH secretion: variation with time of day and relationship to cortisol. Peptides 9:325-331 (Pubitemid 19260239)
28. Sarnyai Z, Mello NK, Mendelson JH, Nguyen PH, Eros-Sarnyai M (1995) Effects of cocaine and corticotropin-releasing factor on pulsatile ACTH and cortisol release in ovariectomized rhesus monkeys. J Clin Endocrinol Metab 80:2745-2751
29. Sarnyai Z, Veldhuis JD, Mello NK et al (1995) The concordance of pulsatile ultradian release of adrenocorticotropin and cortisol in male rhesus monkeys. J Clin Endocrinol Metab 80:54-59
30. Carnes M, Lent SJ, Goodman B, Mueller C, Saydoff J, Erisman S (1990) Effects of immunoneutralization of corticotropin-releasing hormone on ultradian rhythms of plasma adrenocorticotropin. Endocrinology 126:1904-1913 (Pubitemid 20139733)
31. Sarnyai Z, Mello NK, Mendelson JH, Eros-Sarnyai M, Mercer G (1996) Effects of cocaine on pulsatile activity of hypothalamic-pituitary-adrenal axis in male rhesus monkeys: neuroendocrine and behavioral correlates. J Pharmacol Exp Ther 277:225-234
32. Post RM, Kopanda RT, Black KE (1976) Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis. Biol Psychiatry 11:403-419
33. Gawin FH, Kleber HD (1985) Neuroendocrine findings in a chronic cocaine abusers: a preliminary report. Br J Psychiatry 147:569-573 (Pubitemid 16192402)
34. Vescovi PP, Coiro V, Volpi R, Passeri M (1992) Diurnal variations in plasma ACTH, cortisol and beta-endorphin levels in cocaine addicts. Horm Res 37:221-224 (Pubitemid 23053664)
35. Vescovi PP, Coiro V, Volpi R, Giannini A, Passeri M (1992) Hyperthermia in sauna is unable to increase the plasma levels of ACTH/cortisol, beta-endorphin and prolactin in cocaine addicts. J Endocrinol Invest 15:671-675
36. Mendelson JH, Teoh SK, Mello NK, Ellingboe J, Rhoades E (1992) Acute effects of cocaine on plasma adrenocorticotropic hormone, luteinizing hormone and prolactin levels in cocaine-dependent men. J Pharmacol Exp Ther 263:505-509
37. Teoh SK, Sarnyai Z, Mendelson JH et al (1994) Cocaine effects on pulsatile secretion of ACTH in men. J Pharmacol Exp Ther 270:1134-1138 (Pubitemid 24315230)
38. Negro-Vilar A, Johnston C, Spinedi E, Valenca MM, Lopez F (1987) Physiological role of peptides and amines on the regulation of ACTH secretion. Ann NY Acad Sci 512:219-237
39. Gambacciani M, Liu JH, Swartz WH, Tueros VS, Rasmussen DD, Yen SS (1987) Intrinsic pulsatility of ACTH release from the human pituitary in vitro. Clin Endocrinol (Oxf) 26:557-563 (Pubitemid 17052487)
40. Sholar MB, Mendelson JH, Mello NK et al (1998) Concurrent pharmacokinetic analysis of plasma cocaine and adrenocorticotropic hormone in men. J Clin Endocrinol Metab 83:966-968 (Pubitemid 28496477)
41. Baumann MH, Gendron TM, Becketts KM, Henningfield JE, Gorelick DA, Rothman RB (1995) Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers. Biol Psychiatry 38:751-755
42. Elman I, Breiter HC, Gollub RL et al (1999) Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with cocaine dependence. Drug Alcohol Depend 56:39-45 (Pubitemid 29295376)
43. Mendelson JH, Mello NK, Sholar MB, Siegel AJ, Mutschler N, Halpern J (2002) Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. Psychoneuroendocrinology 27:71-82 (Pubitemid 34028158)
44. Phillips K, Luk A, Soor GS, Abraham JR, Leong S, Butany J (2009) Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options. Am J Cardiovasc Drugs 9:177-196
45. Jacobsen TN, Grayburn PA, Snyder RW et al (1997) Effects of intranasal cocaine on sympathetic nerve discharge in humans. J Clin Invest 99:628-634 (Pubitemid 27097663)
46. Vongpatanasin W, Mansour Y, Chavoshan B, Arbique D, Victor RG (1999) Cocaine stimulates the human cardiovascular system via a central mechanism of action. Circulation 100:497-502 (Pubitemid 29360158)
47. Mittleman MA, Mintzer D, Maclure M, Tofler GH, Sherwood JB, Muller JE (1999) Triggering of myocardial infarction by cocaine. Circulation 99:2737-2741 (Pubitemid 29250018)
48. Silaghi A, Silaghi H, Scridon T, Pais R, Achard V (2012) Glucocorticoid receptors in human epicardial adipose tissue: role of coronary status. J Endocrinol Invest 35:649-654
49. Heesch CM, Wilhelm CR, Ristich J, Adnane J, Bontempo FA, Wagner WR (2000) Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans. Heart 83:688-695 (Pubitemid 30345974)
50. Siegel AJ, Mendelson JH, Sholar MB et al (2002) Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen. Am J Cardiol 89:1133-1135 (Pubitemid 34462865)
51. Steffel J, Iseli S, Arnet C, Luscher TF, Tanner FC (2006) Cocaine unbalances endothelial tissue factor and tissue factor pathway inhibitor expression. J Mol Cell Cardiol 40:746-749
52. O'Leary ME, Hancox JC (2010) Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. Br J Clin Pharmacol 69:427-442
53. Ambre JJ, Belknap SM, Nelson J, Ruo TI, Shin SG, Atkinson AJ Jr (1988) Acute tolerance to cocaine in humans. Clin Pharmacol Ther 44:1-8
54. Foltin RW, Haney M (2004) Intranasal cocaine in humans: acute tolerance, cardiovascular and subjective effects. Pharmacol Biochem Behav 78:93-101 (Pubitemid 38670517)
55. Mendelson JH, Sholar M, Mello NK, Teoh SK, Sholar JW (1998) Cocaine tolerance: behavioral, cardiovascular, and neuroendocrine function in men. Neuropsychopharmacology 18:263-271 (Pubitemid 28085525)
56. Elman I, Lukas SE, Karlsgodt KH, Gasic GP, Breiter HC (2003) Acute cortisol administration triggers craving in individuals with cocaine dependence. Psychopharmacol Bull 37:84-89
57. Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ (2003) Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cueinduced cocaine craving states. Psychopharmacology 170:62-72 (Pubitemid 37372479)
58. Ward AS, Collins ED, Haney M, Foltin RW, Fischman MW (1998) Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humans. Behav Pharmacol 9:577-586 (Pubitemid 28552551)
59. Ward AS, Collins ED, Haney M, Foltin RW, Fischman MW (1999) Blockade of cocaine-induced increases in adrenocorticotrophic hormone and cortisol does not attenuate the subjective effects of smoked cocaine in humans. Behav Pharmacol 10:523-529 (Pubitemid 29440560)
60. Quinones-Jenab V (2006) Why are women from Venus and men from Mars when they abuse cocaine? Brain Res 1126:200-203
61. Najavits LM, Lester KM (2008) Gender differences in cocaine dependence. Drug Alcohol Depend 97:190-194
62. Evans SM, Foltin RW (2010) Does the response to cocaine differ as a function of sex or hormonal status in human and non-human primates? Horm Behav 2010(58):13-21
63. Mendelson JH, Mello NK, Sholar MB et al (1999) Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle. Neuropsychopharmacology 21:294-303 (Pubitemid 29304589)
64. Halpern JH, Sholar MB, Glowacki J, Mello NK, Mendelson JH, Siegel AJ (2003) Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration. J Clin Endocrinol Metab 88:1188-1193 (Pubitemid 36337776)
65. Fox HC, Garcia M Jr, Kemp K, Milivojevic V, Kreek MJ, Sinha R (2006) Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals. Psychopharmacology 185:348-357
66. Waldrop AE, Price KL, Desantis SM et al (2010) Community-dwelling cocaine-dependent men and women respond differently to social stressors versus cocaine cues. Psychoneuroendocrinology 35:798-806
67. Jacobsen LK, Giedd JN, Kreek MJ, Gottschalk C, Kosten TR (2001) Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary- adrenal axis function in cocaine dependence: a preliminary report. Drug Alcohol Depend 62:49-56 (Pubitemid 32149964)
68. Buydens-Branchey L, Branchey M, Hudson J, Dorota Majewska M (2002) Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts. Psychoneuroendocrinology 27:83-97 (Pubitemid 34028159)
69. Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R (2008) Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females. Psychopharmacology 195:527-536 (Pubitemid 350160490)
70. Vescovi PP (2000) Cardiovascular and hormonal responses to hyperthermic stress in cocaine addicts after a long period of abstinence. Addict Biol 5:91-95
71. Starkman MN, Giordani B, Berent S, Schork MA, Schteingart DE (2001) Elevated cortisol levels in Cushing's disease are associated with cognitive decrements. Psychosom Med 63:985-993 (Pubitemid 33101385)
72. Michaud K, Forget H, Cohen H (2009) Chronic glucocorticoid hypersecretion in Cushing's syndrome exacerbates cognitive aging. Brain Cogn 71:1-8
73. Starkman MN, Gebarski SS, Berent S, Schteingart DE (1992) Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 32:756-765
74. Maheu FS, Mazzone L, Merke DP et al (2008) Altered amygdala and hippocampus function in adolescents with hypercortisolemia: a functional magnetic resonance imaging study of Cushing syndrome. Dev Psychopathol 20:1177-1189
75. Resmini E, Santos A, Gomez-Anson B et al (2012) Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome. J Clin Endocrinol Metab 97:663-671
76. Jovanovski D, Erb S, Zakzanis KK (2005) Neurocognitive deficits in cocaine users: a quantitative review of the evidence. J Clin Exp Neuropsychol 27:189-204 (Pubitemid 40389048)
77. Di Sclafani V, Tolou-Shams M, Price LJ, Fein G (2002) Neuropsychological performance of individuals dependent on crackcocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence. Drug Alcohol Depend 66:161-171 (Pubitemid 34242893)
78. Fox HC, Jackson ED, Sinha R (2009) Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes. Psychoneuroendocrinology 34:1198-1207
79. Di Sclafani V, Truran DL, Bloomer C et al (1998) Abstinent chronic crack-cocaine and crackcocaine/alcohol abusers evidence normal hippocampal volumes on MRI despite persistent cognitive impairments. Addict Biol 3:261-270 (Pubitemid 28391525)