Glucocorticoid receptors in human epicardial adipose tissue: Role of coronary status

Journal of Endocrinological Investigation

Volumn 35, Issue 7, 2012, Pages 649-654

  Silaghi, A ^a   Silaghi, H ^b   Scridon, T ^c   Pais, R ^b   Achard, V ^d  

^a EMERGENCY COUNTY HOSPITAL   (Romania)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c Cluj Heart Institute   (Romania)

^d HÔPITAL DE LA CONCEPTION   (France)

Author keywords

11 hydroxysteroid dehydrogenase type 1; Cortisol; Epicardial adipose tissue; Glucocorticoid receptor; Promoter

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTISONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA;

ADULT; ARTICLE; BIOPSY; CARDIAC PATIENT; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; EPICARDIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOSE TISSUE, WHITE; ADULT; AGED; BIOPSY; CELL SIZE; CORONARY ARTERY DISEASE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; ORGAN SPECIFICITY; PERICARDIUM; PROMOTER REGIONS, GENETIC; RECEPTORS, GLUCOCORTICOID; RNA SPLICE SITES; RNA, MESSENGER; STROMAL CELLS; SUBCUTANEOUS FAT;

EID: 84865796341     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7969     Document Type: Article

References (36)

1. Girod JP, Brotman DJ. Does altered glucocorticoid homeostasis increase cardiovascular risk? Cardiovasc Res 2004, 64: 217-26.
2. Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 2004, 28 (Suppl 4): S25-65.
3. Iacobellis G, Assael F, Ribaudo MC, et al. Epicardial fat from echo-cardiography: a new method for visceral adipose tissue prediction. Obes Res 2003, 11: 304-10.
4. Iacobellis G, Ribaudo MC, Assael F, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003, 88: 5163-8.
5. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab 2005, 90: 6300-2.
6. Kankaanpää M, Lehto HR, Pärkkä JP, et al. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab 2006, 91: 4689-95.
7. Iacobellis G. Relation of epicardial fat thickness to right ventricular cavity size in obese subjects. Am J Cardiol 2009, 104: 1601-2.
8. Silaghi A, Piercecchi-Marti MD, Grino M, et al. Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy. Obesity 2008, 16: 2424-30.
9. Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003, 108: 2460-6.
10. Kremen J, Dolinkova M, Krajickova J, et al. Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance. J Clin Endocrinol Metab 2006, 91: 4620-7.
11. Dutour A, Achard V, Sell H, et al. Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease. J Clin Endocrinol Metab 2010, 95: 963-7.
12. Iacobellis G, Pistilli D, Gucciardo M, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 2005, 29: 251-5.
13. Silaghi A, Achard V, Paulmyer-Lacroix O, et al. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. Am J Physiol Endocrinol Metab 2007, 293: E1443-50.
14. Faggiano A, Pivonello R, Spiezia S, et al. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab 2003, 88: 2527-33.
15. Rosmond R, Björntorp P. The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Intern Med 2000, 247: 188-97.
16. Lin RC, Wang XL, Morris BJ. Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension 2003, 41: 404-7.
17. Rosmond R, Chagnon YC, Holm G, et al. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamo-pituitary-adrenal axis. Obes Res 2000, 8: 211-8.
18. Ukkola O, Rosmond R, Tremblay A, Bouchard C. Glucocorticoid receptor Bcl I variant is associated with an increased atherogenic profile in response to long-term overfeeding. Atherosclerosis 2001, 157: 221-4.
19. Rask E, Walker BR, Söderberg S, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 2002, 87: 3330-6.
20. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab 2002, 87: 2701-5.
21. Desbriere R, Vuaroqueaux V, Achard V, et al. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring) 2006, 14: 794-8.
22. Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005, 54: 872-9.
23. Boullu-Ciocca S, Paulmyer-Lacroix O, Fina F, et al. Expression of the mRNAs coding for the glucocorticoid receptor isoforms in obesity. Obes Res 2003, 11: 925-9.
24. Pedersen KB, Vedeckis WV. Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 2003, 42: 10978-90.
25. Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 1998, 83: 1325-35.
26. Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 2003, 88: 2738-44.
27. Webster JC, Oakley RH, Jewell CM, Cidlowski JA. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci U S A 2001, 98: 6865-70.
28. Ebrecht M, Buske-Kirschbaum A, Hellhammer D, et al. Tissue specificity of glucocorticoid sensitivity in healthy adults. J Clin Endocrinol Metab 2000, 85: 3733-9.
29. Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 2008, 197: 189-204.
30. Hauner H, Schmid P, Pfeiffer EF. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells. J Clin Endocrinol Metab 1987, 64: 832-5.
31. Halvorsen YD, Bond A, Sen A, et al. Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis. Metabolism 2001, 50: 407-13.
32. Presul E, Schmidt S, Kofler R, Helmberg A. Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor. J Mol Endocrinol 2007, 38: 79-90.
33. Turner JD, Alt SR, Cao L, et al. Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Biochem Pharmacol 2010, 80: 1860-8.
34. Nunez BS, Vedeckis WV. Characterization of promoter 1B in the human glucocorticoid receptor gene. Mol Cell Endocrinol 2002, 189: 191-9.
35. Geng C-D, Vedeckis WV. Steroid responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol Endocrinol 2005, 18: 912-24.
36. Breslin MB, Geng CD, Vedeckis WV. Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 2001, 15: 1381-95.