Pain, depression, and fatigue: Loneliness as a longitudinal risk factor

Health Psychology

Volumn 33, Issue 9, 2014, Pages 948-957

  Jaremka, Lisa M ^a   Andridge, Rebecca R ^a   Fagundes, Christopher P ^a   Alfano, Catherine M ^b   Povoski, Stephen P ^a   Lipari, Adele M ^a   Agnese, Doreen M ^a   Arnold, Mark W ^a   Farrar, William B ^a   Yee, Lisa D ^a   Carson III, William E ^a   Bekaii Saab, Tanios ^a   Martin Jr , Edward W ^a   Schmidt, Carl R ^a   Kiecolt Glaser, Janice K ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aging; Depression; Fatigue; Loneliness; Pain

Indexed keywords

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BECK DEPRESSION INVENTORY; BREAST CANCER; CANCER FATIGUE; CANCER PAIN; CANCER SURVIVOR; CHARLSON COMORBIDITY INDEX; COLORECTAL CANCER; CONTROLLED STUDY; DEMENTIA; DEPRESSION; FEMALE; HUMAN; LONELINESS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; PITTSBURGH SLEEP QUALITY INDEX; RISK FACTOR; SLEEP QUALITY; SPOUSE;

ADULT; AGED; AGED, 80 AND OVER; CAREGIVERS; CASE-CONTROL STUDIES; DEMENTIA; DEPRESSION; FATIGUE; FEMALE; HUMANS; LINEAR MODELS; LONELINESS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEOPLASMS; OHIO; PAIN; QUALITY OF LIFE; RISK FACTORS; SURVIVORS; SYNDROME;

EID: 84907318903     PISSN: 02786133     EISSN: 19307810     Source Type: Journal    
DOI: 10.1037/a0034012     Document Type: Article

References (62)

1. Albers, J. M., Kuper, H. H., Riel, P. L., van Prevoo, M. L., van't Hof, M. A., van Gestel, A. M., & Severens, J. L. (1999). Socio-economic consequences of rheumatoid arthritis in the first years of the disease. Rheumatology, 38, 423-430.
2. Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.
3. Becker, N., Bondegaard Thomsen, A., Olsen, A. K., Sjøgren, P., Bech, P., & Eriksen, J. (1997). Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center. Pain, 73, 393-400.
4. Blazer, D., Hughes, D. C., & George, L. K. (1987). The epidemiology of depression in an elderly community population. The Gerontologist, 27, 281-287.
5. Bower, J. E., Ganz, P. A., Desmond, K. A., Rowland, J. H., Meyerowitz, B. E., & Belin, T. R. (2000). Fatigue in breast cancer survivors: Occurrence, correlates, and impact on quality of life. Journal of Clinical Oncology, 18, 743-753.
6. Bower, J. E., Ganz, P. A., Irwin, M. R., Kwan, L., Breen, E. C., & Cole, S. W. (2011). Inflammation and behavioral symptoms after breast cancer treatment: Do fatigue, depression, and sleep disturbance share a common underlying mechanism? Journal of Clinical Oncology, 29, 3517-3522.
7. Brown, J. C., Huedo-Medina, T. B., Pescatello, L. S., Ryan, S. M., Pescatello, S. M., Moker, E., . . . Johnson, B. T. (2012). The efficacy of exercise in reducing depressive symptoms among cancer survivors: A meta-analysis. PloS ONE, 7, e30955.
8. Burman, B., & Margolin, G. (1992). Analysis of the association between marital relationships and health problems: An interactional perspective. Psychological Bulletin, 112, 39-63.
9. Buysse, D. J., Reynolds, C. F., III, Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193-213.
10. Cacioppo, J. T., Burleson, M. H., Poehlmann, K. M., Malarkey, W. B., Kiecolt-Glaser, J. K., Berntson, G. G., . . . Glaser, R. (2000). Autonomic and neuroendocrine responses to mild psychological stressors: Effects of chronic stress on older women. Annals of Behavioral Medicine, 22, 140-148.
11. Cacioppo, J. T., Hawkley, L. C., Berntson, G. G., Ernst, J. M., Gibbs, A. C., Stickgold, R., & Hobson, J. A. (2002). Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychological Science, 13, 384-387.
12. Cacioppo, J. T., Hawkley, L. C., & Thisted, R. A. (2010). Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychology and Aging, 25, 453-463.
13. Cacioppo, J. T., Hughes, M. E., Waite, L. J., Hawkley, L. C., & Thisted, R. A. (2006). Loneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses. Psychology and Aging, 21, 140-151.
14. Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994). Validation of a combined comorbidity index. Journal of Clinical Epidemiology, 47, 1245-1251.
15. Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9, 46-56.
16. de Groot, V., Beckerman, H., Lankhorst, G. J., & Bouter, L. M. (2003). How to measure comorbidity: A critical review of available methods. Journal of Clinical Epidemiology, 56, 221-229.
17. Diggle, P., Heagerty, P., Liang, K-Y., & Zeger, S. (2002). Analysis of longitudinal data (2nd ed.). New York, NY: Oxford University Press.
18. Elliott, A. M., Smith, B. H., Penny, K. I., Cairns Smith, W., & Alastair Chambers, W. (1999). The epidemiology of chronic pain in the community. The Lancet, 354, 1248-1252.
19. Ershler, W. B., & Keller, E. T. (2000). Age-associated increased Interleukin-6 gene expression, late-life diseases, and frailty. Annual Review of Medicine, 51, 245-270.
20. Fillenbaum, G. G., & Smyer, M. A. (1981). The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. Journal of Gerontology, 36, 428-434.
21. Forbes, A., While, A., Mathes, L., & Griffiths, P. (2006). Health problems and health-related quality of life in people with multiple sclerosis. Clinical Rehabilitation, 20, 67-78.
22. Fox, S. W., & Lyon, D. E. (2006). Symptom clusters and quality of life in survivors of lung cancer. Oncology Nursing Forum, 33, 931-936.
23. Godin, G., & Shephard, R. J. (1985). A simple method to assess exercise behavior in the community. Canadian Journal of Applied Sport Sciences, 10, 141-146.
24. Goldney, R., Fisher, L., Grande, E., & Taylor, A. (2004). Subsyndromal depression: Prevalence, use of health services and quality of life in an Australian population. Social Psychiatry and Psychiatric Epidemiology, 39, 293-298.
25. Hackett, R. A., Hamer, M., Endrighi, R., Brydon, L., & Steptoe, A. (2012). Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women. Psychoneuroendocrinology, 37, 1801-1809.
26. Hardy, S. E., & Studenski, S. A. (2008). Fatigue predicts mortality in older adults. Journal of the American Geriatrics Society, 56, 1910-1914.
27. Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine, 40, 218-227.
28. Hawkley, L. C., Preacher, K. J., & Cacioppo, J. T. (2010). Loneliness impairs daytime functioning but not sleep duration. Health Psychology, 29, 124-129.
29. Hays, R. D., Sherbourne, C. D., & Mazel, R. M. (1993). The RAND 36-item health survey 1.0. Health Economics, 2, 217-227.
30. Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7, e1000316.
31. Jaremka, L. M., Fagundes, C. P., Glaser, R., Bennett, J. M., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013). Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation. Psychoneuroendocrinology, 38, 1310-1317.
32. Jaremka, L. M., Fagundes, C. P., Peng, J., Bennett, J. M., Glaser, R., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013). Loneliness promotes inflammation during acute stress. Psychological Science, 24, 1089-1097.
33. Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proceedings of the National Academy of Sciences of the United States if America, 100, 9090-9095.
34. Laird, B. J. A., Scott, A. C., Colvin, L. A., McKeon, A.-L., Murray, G. D., Fearon, K. C. H., & Fallon, M. T. (2011). Pain, depression, and fatigue as a symptom cluster in advanced cancer. Journal of Pain and Symptom Management, 42(1), 1-11.
35. Landmark, T., Romundstad, P., Borchgrevink, P. C., Kaasa, S., & Dale, O. (2011). Associations between recreational exercise and chronic pain in the general population: Evidence from the HUNT 3 study. Pain, 152, 2241-2247.
36. Lenz, E. R., Pugh, L. C., Milligan, R. A., Gift, A., & Suppe, F. (1997). The middle-range theory of unpleasant symptoms: An update. Advances in nursing science, 19, 14-27.
37. Luo, Y., Hawkley, L. C., Waite, L. J., & Cacioppo, J. T. (2012). Loneliness, health, and mortality in old age: A national longitudinal study. Social Science&Medicine, 74, 907-914.
38. Marchand, F., Perretti, M., & McMahon, S. B. (2005). Role of the immune system in chronic pain. Nature Reviews Neuroscience, 6, 521-532.
39. McMillan, E. M., & Newhouse, I. J. (2011). Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: A meta-analysis. Applied Physiology, Nutrition, and Metabolism, 36, 892-903.
40. Moreh, E., Jacobs, J. M., & Stessman, J. (2010). Fatigue, function, and mortality in older adults. The Journals of Gerontology, 65, 887-895.
41. Motl, R. W., & McAuley, E. (2009). Symptom cluster as a predictor of physical activity in multiple sclerosis: Preliminary evidence. Journal of Pain and Symptom Management, 38, 270-280.
42. Motl, R. W., & McAuley, E. (2010). Symptom cluster and quality of life: Preliminary evidence in multiple sclerosis. The Journal of Neuroscience Nursing, 42, 212-216.
43. National Institute of Health. (2002). Symptom management in cancer: Pain, depression, and fatigue. NIH Consensus State-of-the-Science Statements, 19, 1-29.
44. Nicassio, P. M., Moxham, E. G., Schuman, C. E., & Gevirtz, R. N. (2002). The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain, 100, 271-279.
45. Ohayon, M. M., & Schatzberg, A. F. (2003). Using chronic pain to predict depressive morbidity in the general population. Archives of General Psychiatry, 60, 39-47.
46. Peel, C., Sawyer Baker, P., Roth, D. L., Brown, C. J., Brodner, E. V., & Allman, R. M. (2005). Assessing mobility in older adults: The UAB Study of Aging Life-Space Assessment. Physical Therapy, 85, 1008-1119.
47. Pereira, M. A., Fitzgerald, S. J., Gregg, E. W., Joswiak, M. L., Ryan, W. J., Suminski, R. R., . . . Zmuda, J. M. (1997). A collection of Physical Activity Questionnaires for health-related research. Medicine & Science in Sports&Exercise, 29, S1-S205.
48. Perissinotto, C. M., Stijacic Cenzer, I., & Covinsky, K. E. (2012). Loneliness in older persons: A predictor of functional decline and death. Archives of internal medicine, 172, 1078-1083.
49. Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385-401.
50. Reyes-Gibby, C. C., Aday, L. A., Anderson, K. O., Mendoza, T. R., & Cleeland, C. S. (2006). Pain, depression, and fatigue in communitydwelling adults with and without a history of cancer. Journal of Pain and Symptom Management, 32, 118-128.
51. Reynolds, W. M.,&Gould, J. W. (1981). A psychometric investigation of the standard and short form Beck Depression Inventory. Journal of Consulting and Clinical Psychology, 49, 306-307.
52. Rubenstein, C.,&Shaver, P. (1982). The experience of loneliness. In L. A. Peplau&D. Perlman (Eds.), Loneliness: A sourcebook of current theory, research and therapy (1st ed., Vol. 36, pp. 207-223). Hoboken, NJ: Wiley.
53. Russell, D. W. (1996). UCLA Loneliness Scale (Version 3): Reliability, validity, and factor structure. Journal of Personality Assessment, 66, 20-40.
54. Schulz, R., Beach, S. R., Ives, D. G., Martire, L. M., Ariyo, A. A.,&Kop, W. J. (2000). Association between depression and mortality in older adults: The Cardiovascular Health Study. Archives of Internal Medicine, 160, 1761-1768.
55. Stein, K. D., Jacobsen, P. B., Blanchard, C. M.,&Thors, C. (2004). Further validation of the multidimensional fatigue symptom inventory-short form. Journal of Pain and Symptom Management, 27, 14-23.
56. Stepanski, E. J., Walker, M. S., Schwartzberg, L. S., Blakely, L. J., Ong, J. C., & Houts, A. C. (2009). The relation of trouble sleeping, depressed mood, pain, and fatigue in patients with cancer. Journal of Clinical Sleep Medicine, 5, 132-136.
57. Sugisawa, H., Liang, J., & Liu, X. (1994). Social networks, social support, and mortality among older people in Japan. Journal of Gerontology, 49, S3-S13.
58. Thornton, L. M., Andersen, B. L., & Blakely, W. P. (2010). The pain, depression, and fatigue symptom cluster in advanced breast cancer: Covariation with the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Health Psychology, 29, 333-337.
59. Thurston, R. C., & Kubzansky, L. D. (2009). Women, loneliness, and incident coronary heart disease. Psychosomatic Medicine, 71, 836-842.
60. Vander Zee, K. I., Sanderman, R., Heyink, J. W., & de Haes, H. (1996). Psychometric qualities of the RAND 36-Item Health Survey 1.0: A multidimensional measure of general health status. International Journal of Behavioral Medicine, 3, 104-122.
61. Van't Leven, M., Zielhuis, G. A., van der Meer, J. W., Verbeek, A. L., & Bleijenberg, G. (2010). Fatigue and chronic fatigue syndrome-like complaints in the general population. European Journal of Public Health, 20, 251-257.
62. Walker, E. A., Katon, W. J., & Jemelka, R. P. (1993). Psychiatric disorders and medical care utilization among people in the general population who report fatigue. Journal of General Internal Medicine, 8, 436-440.