The efficacy of exercise in reducing depressive symptoms among cancer survivors: A meta-analysis

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Brown, Justin C ^a   Huedo Medina, Tania B ^b   Pescatello, Linda S ^b   Ryan, Stacey M ^c   Pescatello, Shannon M ^d   Moker, Emily ^b   LaCroix, Jessica M ^b   Ferrer, Rebecca A ^e   Johnson, Blair T ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d WESTERN NEW ENGLAND UNIVERSITY   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEROBIC EXERCISE; ARTICLE; BREAST CANCER; CANCER SURVIVOR; COLORECTAL CANCER; DEPRESSION; EXERCISE; HUMAN; LEUKEMIA; LYMPHOMA; META ANALYSIS; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL (TOPIC); ADULT; AGED; FEMALE; KINESIOTHERAPY; MALE; MIDDLE AGED; NEOPLASM; PSYCHOLOGICAL ASPECT; SURVIVOR; TREATMENT OUTCOME;

ADULT; AGED; DEPRESSION; EXERCISE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; SURVIVORS; TREATMENT OUTCOME;

EID: 84856386446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030955     Document Type: Article

References (90)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61 (2): 69-90.
2. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, et al. (2010) American college of sports medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42 (7): 1409-1426.
3. Reich M, Lesur A, Perdrizet-Chevallier C, (2008) Depression, quality of life and breast cancer: A review of the literature. Breast Cancer Res Treat 110 (1): 9-17.
4. Newport DJ, Nemeroff CB, (1998) Assessment and treatment of depression in the cancer patient. J Psychosom Res 45 (3): 215-237.
5. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE, (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62 (6): 617-627.
6. Lebovits AH, Strain JJ, Schleifer SJ, Tanaka JS, Bhardwaj S, et al. (1990) Patient noncompliance with self-administered chemotherapy. Cancer 65 (1): 17-22.
7. Gilbar O, De-Nour AK, (1989) Adjustment to illness and dropout of chemotherapy. J Psychosom Res 33 (1): 1-5.
8. Watson M, Haviland JS, Greer S, Davidson J, Bliss JM, (1999) Influence of psychological response on survival in breast cancer: A population-based cohort study. Lancet 354 (9187): 1331-1336.
9. Pasquini M, Biondi M, (2007) Depression in cancer patients: A critical review. Clin Pract Epidemiol Ment Health 3: 2.
10. Conn VS, (2010) Depressive symptom outcomes of physical activity interventions: Meta-analysis findings. Ann Behav Med 39 (2): 128-138.
11. Coventry PA, Hind D, (2007) Comprehensive pulmonary rehabilitation for anxiety and depression in adults with chronic obstructive pulmonary disease: Systematic review and meta-analysis. J Psychosom Res 63 (5): 551-565.
12. O'Brien K, Nixon S, Tynan AM, Glazier R, (2010) Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev (8) (8): CD001796.
13. Clark AM, Haykowsky M, Kryworuchko J, MacClure T, Scott J, et al. (2010) A meta-analysis of randomized control trials of home-based secondary prevention programs for coronary artery disease. Eur J Cardiovasc Prev Rehabil 17 (3): 261-270.
14. Ferrer RA, Huedo-Medina TB, Johnson BT, Ryan S, Pescatello LS, (2011) Exercise interventions for cancer survivors: A meta-analysis of quality of life outcomes. Ann Behav Med 41 (1): 32-47.
15. Brown JC, Huedo-Medina TB, Pescatello LS, Pescatello SM, Ferrer RA, et al. (2011) Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: A meta-analysis. Cancer Epidemiol Biomarkers Prev 20 (1): 123-133.
16. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH, (2010) An update of controlled physical activity trials in cancer survivors: A systematic review and meta-analysis. J Cancer Surviv 4 (2): 87-100.
17. Daley AJ, Crank H, Saxton JM, Mutrie N, Coleman R, et al. (2007) Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol 25 (13): 1713-1721.
18. Courneya KS, Sellar CM, Stevinson C, McNeely ML, Peddle CJ, et al. (2009) Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol 27 (27): 4605-4612.
19. Culos-Reed SN, Robinson JW, Lau H, Stephenson L, Keats M, et al. (2010) Physical activity for men receiving androgen deprivation therapy for prostate cancer: Benefits from a 16-week intervention. Support Care Cancer 18 (5): 591-599.
20. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, et al. (2007) Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: A multicenter randomized controlled trial. J Clin Oncol 25 (28): 4396-4404.
21. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, et al. (2000) Compendium of physical activities: An update of activity codes and MET intensities. Med Sci Sports Exerc 32 (9 Suppl): S498-504.
22. Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M, (2003) Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther 83 (8): 713-721.
23. Reddon JR, Marceau R, Holden RR, (1985) A confirmatory evaluation of the profile of mood states: Convergent and discriminant item validity. Journal of Psychopathology and Behavioral Assessment 7 (3): 243-259.
24. Salkind MR, (1969) Beck depression inventory in general practice. J R Coll Gen Pract 18 (88): 267-271.
25. Kohout FJ, Berkman LF, Evans DA, Cornoni-Huntley J, (1993) Two shorter forms of the CES-D (center for epidemiological studies depression) depression symptoms index. J Aging Health 5 (2): 179-193.
26. Zigmond AS, Snaith RP, (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67 (6): 361-370.
27. Sutherland HJ, Walker P, Till JE, (1988) The development of a method for determining oncology patients' emotional distress using linear analogue scales. Cancer Nurs 11 (5): 303-308.
28. Hedges LV, Olkin I, (1985) Statistical methods for meta-analysis Orlando, FL Academic Press Inc.
29. Becker BJ, (1988) Synthesizing standardized mean-change measures. Br J Math Stat Psychol 41 (2): 257-278.
30. Morris SB, DeShon RP, (2002) Combining effect size estimates in meta-analysis with repeated measures and independent-groups designs. Psychol Methods 7 (1): 105-125.
31. Cohen J, (1998) Statistical power analysis for the behavioral sciences New York, NY Erlbaum.
32. Becker BJ, (2000) Handbook of applied multivariate statistics and mathematical modeling San Diego, CA Academic Press pp. 499-525.
33. Lipsey MW, Wilson DB, (2001) Practical meta-analysis Thousand Oaks, CA SAGE.
34. Begg CB, Mazumdar M, (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50 (4): 1088-1101.
35. Egger M, Smith GD, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315 (7109): 629-634.
36. Duval S, Tweedie R, (2000) A nonparametric "trim and fill" method of accounting for publication bias in meta-analysis. Journal of the American Statistical Association 95 (449): 89-98.
37. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21 (11): 1539-1558.
38. Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J, (2006) Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods 11 (2): 193-206.
39. Harbord RM, Higgins JPT, (2008) Meta-regression in stata. The Stata Journal 8 pp. 493-519.
40. Thompson SG, Higgins JP, (2002) How should meta-regression analyses be undertaken and interpreted? Stat Med 21 (11): 1559-1573.
41. Johnson BT, Huedo-Medina TB, (2011) Depicting estimates using the intercept in meta-regression models:The moving constant technique. Research Syn Method.
42. Burnham TR, Wilcox A, (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34 (12): 1863-1867.
43. Dimeo FC, Stieglitz RD, Novelli-Fischer U, Fetscher S, Keul J, (1999) Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer 85 (10): 2273-2277.
44. Dodd MJ, Cho MH, Miaskowski C, Painter PL, Paul SM, et al. (2010) A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy. Cancer Nurs 33 (4): 245-257.
45. Berglund G, Bolund C, Gustafsson UL, Sjoden PO, (1994) One-year follow-up of the 'starting again' group rehabilitation programme for cancer patients. Eur J Cancer 30A (12): 1744-1751.
46. Courneya KS, Friedenreich CM, Sela RA, Quinney HA, Rhodes RE, et al. (2003) The group psychotherapy and home-based physical exercise (group-hope) trial in cancer survivors: Physical fitness and quality of life outcomes. Psychooncology 12 (4): 357-374.
47. Thorsen L, Skovlund E, Stromme SB, Hornslien K, Dahl AA, et al. (2005) Effectiveness of physical activity on cardiorespiratory fitness and health-related quality of life in young and middle-aged cancer patients shortly after chemotherapy. J Clin Oncol 23 (10): 2378-2388.
48. Culos-Reed SN, Carlson LE, Daroux LM, Hately-Aldous S, (2006) A pilot study of yoga for breast cancer survivors: Physical and psychological benefits. Psychooncology 15 (10): 891-897.
49. Rausch SM, (2007) Evaluating the psychosocial effects of two interventions, tai chi and spiritual growth groups, in women with breast cancer. PhD Dissertation.
50. Ohira T, Schmitz KH, Ahmed RL, Yee D, (2006) Effects of weight training on quality of life in recent breast cancer survivors: The weight training for breast cancer survivors (WTBS) study. Cancer 106 (9): 2076-2083.
51. Perna FM, Craft L, Freund KM, Skrinar G, Stone M, et al. (2010) The effect of a cognitive behavioral exercise intervention on clinical depression in a multiethnic sample of women with breast cancer: A randomized controlled trial. International Journal of Sport and Exercise Psychology 8 (1): 36-47.
52. Lee SA, Kang JY, Kim YD, An AR, Kim SW, et al. (2010) Effects of a scapula-oriented shoulder exercise programme on upper limb dysfunction in breast cancer survivors: A randomized controlled pilot trial. Clin Rehabil 24 (7): 600-613.
53. Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, et al. (2008) Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer 8 (1): 70-79.
54. Targ EF, Levine EG, (2002) The efficacy of a mind-body-spirit group for women with breast cancer: A randomized controlled trial. Gen Hosp Psychiatry 24 (4): 238-248.
55. Mutrie N, Campbell AM, Whyte F, McConnachie A, Emslie C, et al. (2007) Benefits of supervised group exercise programme for women being treated for early stage breast cancer: Pragmatic randomised controlled trial. BMJ 334 (7592): 517.
56. Latka RN, Alvarez-Reeves M, Cadmus L, Irwin ML, (2009) Adherence to a randomized controlled trial of aerobic exercise in breast cancer survivors: The yale exercise and survivorship study. J Cancer Surviv 3 (3): 148-157.
57. Patel SR, (2004) The effects of yoga on mood disturbance and pain in an underserved breast cancer population. PhD Dissertation.
58. Vadiraja HS, Raghavendra RM, Nagarathna R, Nagendra HR, Rekha M, et al. (2009) Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: A randomized controlled trial. Integr Cancer Ther 8 (1): 37-46.
59. McClure MK, McClure RJ, Day R, Brufsky AM, (2010) Randomized controlled trial of the breast cancer recovery program for women with breast cancer-related lymphedema. Am J Occup Ther 64 (1): 59-72.
60. Pinto BM, Clark MM, Maruyama NC, Feder SI, (2003) Psychological and fitness changes associated with exercise participation among women with breast cancer. Psychooncology 12 (2): 118-126.
61. Mock V, Dow KH, Meares CJ, Grimm PM, Dienemann JA, et al. (1997) Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Oncol Nurs Forum 24 (6): 991-1000.
62. Danhauer SC, Mihalko SL, Russell GB, Campbell CR, Felder L, et al. (2009) Restorative yoga for women with breast cancer: Findings from a randomized pilot study. Psychooncology 18 (4): 360-368.
63. Cadmus LA, Salovey P, Yu H, Chung G, Kasl S, et al. (2009) Exercise and quality of life during and after treatment for breast cancer: Results of two randomized controlled trials. Psychooncology 18 (4): 343-352.
64. Drouin JS, Armstrong H, Krause S, Orr J, Birk TJ, et al. (2005) Effects of aerobic exercise training on peak aerobic capacity, fatigue, and psyhchological factors during radiation for breast cancer. Rehabilitation Oncology 1 (23): 11-17.
65. Chandwani KD, Thornton B, Perkins GH, Arun B, Raghuram NV, et al. (2010) Yoga improves quality of life and benefit finding in women undergoing radiotherapy for breast cancer. J Soc Integr Oncol 8 (2): 43-55.
66. Vito NL, (2007) The effects of a yoga intervention on physical and psychological functioning for breast cancer survivors. PhD Dissertation.
67. Payne JK, Held J, Thorpe J, Shaw H, (2008) Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy. Oncol Nurs Forum 35 (4): 635-642.
68. Mock V, Burke MB, Sheehan P, Creaton EM, Winningham ML, et al. (1994) A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum 21 (5): 899-907; discussion 908.
69. Eyigor S, Karapolat H, Yesil H, Uslu R, Durmaz B, (2010) Effects of pilates exercises on functional capacity, flexibility, fatigue, depression and quality of life in female breast cancer patients: A randomized controlled study. Eur J Phys Rehabil Med 46 (4): 481-487.
70. Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, et al. (2007) Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Arch Phys Med Rehabil 88 (11): 1416-1422.
71. Courneya KS, Friedenreich CM, Quinney HA, Fields AL, Jones LW, et al. (2003) A randomized trial of exercise and quality of life in colorectal cancer survivors. European Journal of Cancer Care 12 (4): 347-357.
72. Jarden M, Nelausen K, Hovgaard D, Boesen E, Adamsen L, (2009) The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: A randomized controlled trial. J Pain Symptom Manage 38 (2): 174-190.
73. Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, et al. (2008) Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: A randomized controlled trial. J Pain Symptom Manage 35 (5): 524-534.
74. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A, (2004) Psychological adjustment and sleep quality in a randomized trial of the effects of a tibetan yoga intervention in patients with lymphoma. Cancer 100 (10): 2253-2260.
75. Duijts SF, Faber MM, Oldenburg HS, van Beurden M, Aaronson NK, (2011) Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors-a meta-analysis. Psychooncology 20 (2): 115-126.
76. Craft L, Vaniterson EH, Helenowski IB, Rademaker A, Courneya KS, (2011) Exercise effects on depressive symptoms in cancer survivors: A systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev.
77. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO, (2005) Exercise treatment for depression: Efficacy and dose response. Am J Prev Med 28 (1): 1-8.
78. Jones LW, Eves ND, Peppercorn J, (2010) Pre-exercise screening and prescription guidelines for cancer patients. Lancet Oncol 11 (10): 914-916.
79. Thompson WR, Gordon NF, Pescatello LS, eds. (2010) ACSM's guidelines for exercise testing and prescription Philadelphia, PA Lippincott, Williams & Wilkins.
80. Velthuis MJ, Agasi-Idenburg SC, Aufdemkampe G, Wittink HM, (2010) The effect of physical exercise on cancer-related fatigue during cancer treatment: A meta-analysis of randomised controlled trials. Clin Oncol (R Coll Radiol) 22 (3): 208-221.
81. Spence RR, Heesch KC, Brown WJ, (2011) Colorectal cancer survivors' exercise experiences and preferences: Qualitative findings from an exercise rehabilitation programme immediately after chemotherapy. Eur J Cancer Care (Engl) 20 (2): 257-266.
82. Whitehead S, Lavelle K, (2009) Older breast cancer survivors' views and preferences for physical activity. Qual Health Res 19 (7): 894-906.
83. Mor V, Allen S, Malin M, (1994) The psychosocial impact of cancer on older versus younger patients and their families. Cancer 74 (7 Suppl): 2118-2127.
84. Mao JJ, Armstrong K, Bowman MA, Xie SX, Kadakia R, et al. (2007) Symptom burden among cancer survivors: Impact of age and comorbidity. J Am Board Fam Med 20 (5): 434-443.
85. Holland JC, Andersen B, Breitbart WS, Compas B, Dudley MM, et al. (2010) Distress management. J Natl Compr Canc Netw 8 (4): 448-485.
86. Brosse AL, Sheets ES, Lett HS, Blumenthal JA, (2002) Exercise and the treatment of clinical depression in adults: Recent findings and future directions. Sports Med 32 (12): 741-760.
87. North TC, McCullagh P, Tran ZV, (1990) Effect of exercise on depression. Exerc Sport Sci Rev 18: 379-415.
88. Papakostas GI, (2008) Tolerability of modern antidepressants. J Clin Psychiatry 69 (Suppl E1): 8-13.
89. Kelly CM, Juurlink DN, Gomes T, Duong-Hua M, Pritchard KI, et al. (2010) Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: A population based cohort study. BMJ 340: c693.
90. Greenwood BN, Fleshner M, (2011) Exercise, stress resistance, and central serotonergic systems. Exerc Sport Sci Rev 39 (3): 140-149.