Loneliness predicts pain, depression, and fatigue: Understanding the role of immune dysregulation

Psychoneuroendocrinology

Volumn 38, Issue 8, 2013, Pages 1310-1317

  Jaremka, Lisa M ^a   Fagundes, Christopher P ^a   Glaser, Ronald ^a   Bennett, Jeanette M ^b   Malarkey, William B ^a   Kiecolt Glaser, Janice K ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Cytomegalovirus; Depression; Epstein Barr virus; Fatigue; Herpesvirus; Immune dysregulation; Loneliness; Pain; Symptom cluster

Indexed keywords

VIRUS ANTIBODY;

ANTIBODY TITER; ARTICLE; BLOOD SAMPLING; BREAST CANCER; CANCER PATIENT; CANCER SURVIVOR; CYTOMEGALOVIRUS; DEPRESSION; EPSTEIN BARR VIRUS; FATIGUE; HUMAN; IMMUNE DYSREGULATION; IMMUNOASSAY; LONELINESS; PAIN; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; SOCIAL INTERACTION; TREATMENT DURATION; VIRUS REACTIVATION;

ADULT; AGED; ANTIBODIES, VIRAL; BREAST NEOPLASMS; CYTOMEGALOVIRUS; DEPRESSION; FATIGUE; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; LONELINESS; MIDDLE AGED; PAIN; SURVIVORS;

EID: 84878632229     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2012.11.016     Document Type: Article

References (73)

1. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., Sethi G. Inflammation and cancer: how hot is the link?. Biochem. Pharmacol. 2006, 72:1605-1621.
2. Bair M.J., Robinson R.L., Katon W., Kroenke K. Depression and pain comorbidity: a literature review. Arch. Intern. Med. 2003, 163:2433-2445.
3. Becker N., Bondegaard Thomsen A., Olsen A.K., Sjøgren P., Bech P., Eriksen J. Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center. Pain 1997, 73:393-400.
4. Berlin A.A., Kop W.J., Deuster P.A. Depressive mood symptoms and fatigue after exercise withdrawal: the potential role of decreased fitness. Psychosom. Med. 2006, 68:224-230.
5. Bower J.E., Ganz P.A., Desmond K.A., Rowland J.H., Meyerowitz B.E., Belin T.R. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J. Clin. Oncol. 2000, 18:743-753.
6. Buemi M., Allegra A., Aloisi C., Corica F., Alonci A., Ruello A., Montalto G., Frisina N. Cold pressor test raises serum concentrations of ICAM-1, VCAM-1, and E-Selectin in normotensive and hypertensive patients. Hypertension 1997, 30:845-847.
7. Buysse D.J., Reynolds C.F., Monk T.H., Berman S.R., Kupfer D.J. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989, 28:193-213.
8. Cacioppo J.T., Hawkley L.C., Crawford L.E., Ernst J.M., Burleson M.H., Kowalewski R.B., Malarkey W.B., Van Cauter E., Berntson G.G. Loneliness and health: potential mechanisms. Psychosom. Med. 2002, 64:407-417.
9. Cacioppo J.T., Hawkley L.C., Thisted R.A. Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health Aging, and Social Relations Study. Psychol. Aging 2010, 25:453-463.
10. Cappuccio F.P., D'Elia L., Strazzullo P., Miller M.A. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010, 33:585-592.
11. Charlson M., Szatrowski T.P., Peterson J., Gold J. Validation of a combined comorbidity index. J. Clin. Epidemiol. 1994, 47:1245-1251.
12. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., Jones D.W., Materson B.J., Oparil S., Wright J.T., et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure - The JNC 7 Report. JAMA 2003, 289:2560-2572.
13. Cleeland C.S., Bennett G.J., Dantzer R., Dougherty P.M., Dunn A.J., Meyers C.A., Miller A.H., Payne R., Reuben J.M., Wang X.S., et al. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer 2003, 97:2919-2925.
14. Cole S.W., Hawkley L.C., Arevalo J.M., Sung C.Y., Rose R.M., Cacioppo J.T. Social regulation of gene expression in human leukocytes. Genome Biol. 2007, 8:R189.
15. Collado-Hidalgo A., Bower J.E., Ganz P.A., Cole S.W., Irwin M.R. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin. Cancer Res. 2006, 12:2759-2766.
16. Deshmane S.L., Kremlev S., Amini S., Sawaya B.E. Monocyte chemoattractant protein-1 (MCP-1): An overview. J. Interferon Cytokine Res. 2009, 29:313-326.
17. Dixon D., Cruess S., Kilbourn K., Klimas N., Fletcher M.A., Ironson G., Baum A., Schneiderman N., Antoni M.H. Social support mediates loneliness and human herpesvirus type 6 (HHV-6) antibody titers. J. Appl. Soc. Psychol. 2006, 31:1111-1132.
18. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctot K.L. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67:446-457.
19. Ershler W.B., Keller E.T. Age-associated increased Interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 2000, 51:245-270.
20. Esterling B.A., Antoni M.H., Schneiderman N., Carver C.S., LaPerriere A., Ironson G., Klimas N.G., Fletcher M.A. Psychosocial modulation of antibody to Epstein-Barr viral capsid antigen and human herpesvirus type-6 in HIV-1-infected and at-risk gay men. Psychosom. Med. 1992, 54:354-371.
21. Fagundes C.P., Glaser R., Alfano C.M., Bennett J.M., Povoski S.P., Lipari A.M., Agnese D.M., Yee L.D., Carson W.E., Farrar W.B., et al. Fatigue and herpesvirus latency in women newly diagnosed with breast cancer. Brain Behav. Immun. 2012, 26:394-400.
22. Fleishman S.B. Treatment of symptom clusters: pain, depression, and fatigue. J. Natl. Cancer Inst. Monogr. 2004, 2004:119-123.
23. Given C.W., Given B., Azzouz F., Kozachik S., Stommel M. Predictors of pain and fatigue in the year following diagnosis among elderly cancer patients. J Pain Symptom Manage. 2001, 21:456-466.
24. Glaser R., Jones J. Human Herpesvirus Infections 1994, Dekker, New York, NY.
25. Glaser R., Kiecolt-Glaser J.K. Stress-induced immune dysfunction: implications for health. Nat. Rev. Immunol. 2005, 5:243-251.
26. Glaser R., Kiecolt-Glaser J.K., Speicher C.E., Holliday J.E. Stress, loneliness, and changes in herpesvirus latency. J. Behav. Med. 1985, 8:249-260.
27. Glaser R., Litsky M.L., Padgett D.A., Baiocchi R.A., Yang E.V., Chen M., Yeh P.-E., Green-Church K.B., Caligiuri M.A., Williams M.V. EBV-encoded dUTPase induces immune dysregulation: implications for the pathophysiology of EBV-associated disease. Virology 2006, 346:205-218.
28. Glaser R., Robles T.F., Sheridan J., Malarkey W.B., Kiecolt-Glaser J.K. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Arch. Gen. Psychiatry 2003, 60:1009-1014.
29. Glaser R., Strain E.C., Tarr K.L., Holliday J.E., Donnerberg R.L., Kiecolt-Glaser J.K. Changes in Epstein-Barr virus antibody titers associated with aging. Proc. Soc. Exp. Biol. Med. 1985, 179:352-355.
30. Hackett R.A., Hamer M., Endrighi R., Brydon L., Steptoe A. Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women. Psychoneuroendocrinology 2012, 37:1801-1809.
31. Hardy S.E., Studenski S.A. Fatigue predicts mortality in older adults. J. Am. Geriatr. Soc. 2008, 56:1910-1914.
32. Hawkley L.C., Burleson M.H., Berntson G.G., Cacioppo J.T. Loneliness in everyday life: cardiovascular activity, psychosocial context, and health behaviors. J. Pers. Soc. Psychol. 2003, 85:105-120.
33. Hawkley L.C., Cacioppo J.T. Loneliness and pathways to disease. Brain Behav. Immun. 2003, 17(Suppl. 1):S98-S105.
34. Hawkley L.C., Cacioppo J.T. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann. Behav. Med. 2010, 40:218-227.
35. Hawkley L.C., Preacher K.J., Cacioppo J.T. Loneliness impairs daytime functioning but not sleep duration. Health Psychol. 2010, 29:124-129.
36. Hawkley L.C., Thisted R.A., Cacioppo J.T. Loneliness predicts reduced physical activity: cross-sectional & longitudinal analyses. Health Psychol. 2009, 28:354-363.
37. Hawkley L.C., Thisted R.A., Masi C.M., Cacioppo J.T. Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults. Psychol. Aging 2010, 25:132-141.
38. Hays R.D., Sherbourne C.D., Mazel R.M. The RAND 36-item health survey 1.0. Health Econ. 1993, 2:217-227.
39. Irwin M. Effects of sleep and sleep loss on immunity and cytokines. Brain Behav. Immun. 2002, 16:503-512.
40. Jaremka, L.M., Fagundes, C.P., Peng, J., Bennett, J.M., Glaser, R., Malarkey, W.B., Kiecolt-Glaser, J.K. Loneliness promotes inflammation during acute stress. Psychol. Sci., in press.
41. Joynt K.E., Whellan D.J., O'Connor C.M. Depression and cardiovascular disease: mechanisms of interaction. Biol. Psychiatry 2003, 54:248-261.
42. Kiecolt-Glaser J.K., Garner W., Speicher C., Penn G.M., Holliday J., Glaser R. Psychosocial modifiers of immunocompetence in medical students. Psychosom. Med. 1984, 46:7-14.
43. Kiecolt-Glaser J.K., Ricker D., George J., Messick G., Speicher C., Garner W., Glaser R. Urinary cortisol levels, cellular immunocompetency, and loneliness in psychiatric inpatients. Psychosom. Med. 1984, 46:15-23.
44. Kurina L.M., Knutson K.L., Hawkley L.C., Cacioppo J.T., Lauderdale D.S., Ober C. Loneliness is associated with sleep fragmentation in a communal society. Sleep 2011, 34:1519-1526.
45. Laird B.J.A., Scott A.C., Colvin L.A., McKeon A.-L., Murray G.D., Fearon K.C.H., Fallon M.T. Pain, depression, and fatigue as a symptom cluster in advanced cancer. J. Pain Symptom Manage. 2011, 42:1-11.
46. Landmark T., Romundstad P., Borchgrevink P.C., Kaasa S., Dale O. Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 study. Pain 2011, 152:2241-2247.
47. Marchand F., Perretti M., McMahon S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 2005, 6:521-532.
48. Matalka K.Z., Sidki A., Abdul-Malik S.M., Thewaini A.J. Academic stress - influence on Epstein-Barr virus and cytomegalovirus reactivation, cortisol, and prolactin. Lab. Med. 2000, 31:163-168.
49. McNeely M.L., Campbell K.L., Rowe B.H., Klassen T.P., Mackey J.R., Courneya K.S. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ 2006, 175:34-41.
50. Mehta S.K., Pierson D.L. Reactivation of latent herpes viruses in cosmonauts during a Soyuz taxi mission. Microgravity Sci. Technol. 2007, 19:215-218.
51. Motl R.W., McAuley E. Symptom cluster as a predictor of physical activity in multiple sclerosis: preliminary evidence. J. Pain Symptom Manage. 2009, 38:270-280.
52. Motl R.W., McAuley E. Symptom cluster and quality of life: preliminary evidence in multiple sclerosis. J. Neurosci. Nurs. 2010, 42:212-216.
53. Nicassio P.M., Moxham E.G., Schuman C.E., Gevirtz R.N. The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain 2002, 100:271-279.
54. Ohayon M.M., Schatzberg A.F. Using chronic pain to predict depressive morbidity in the general population. Arch. Gen. Psychiatry 2003, 60:39-47.
55. Oishi S., Schiller J., Gross E.B. Felt understanding and misunderstanding affect the perception of pain, slant, and distance. Soc. Psychol. Pers. Sci. 2012.
56. Palesh O.G., Roscoe J.A., Mustian K.M., Roth T., Savard J., Ancoli-Israel S., Heckler C., Purnell J.Q., Janelsins M.C., Morrow G.R. Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center - Community Clinical Oncology Program. J. Clin. Oncol. 2010, 28:292-298.
57. Phillips A.C., Carroll D., Khan N., Moss P. Cytomegalovirus is associated with depression and anxiety in older adults. Brain Behav. Immun. 2008, 22:52-55.
58. Preacher K.J., Hayes A.F. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav. Res. Methods 2008, 40:879-891.
59. Pressman S.D., Cohen S., Miller G.E., Barkin A., Rabin B.S., Treanor J.J. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. 2005, 24:297-306.
60. Radloff L.S. The CES-D Scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1977, 1:385-401.
61. Reyes-Gibby C.C., Aday L.A., Anderson K.O., Mendoza T.R., Cleeland C.S. Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer. J. Pain Symptom Manage. 2006, 32:118-128.
62. Reyes-Gibby C.C., Mendoza T.R., Wang S., Anderson K.O., Cleeland C.S. Pain and fatigue in community-dwelling adults. Pain Med. 2003, 4:231-237.
63. Roberts E.T., Haan M.N., Dowd J.B., Aiello A.E. Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am. J. Epidemiol. 2010, 172:363-371.
64. Russell D.W. UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. J. Pers. Assess. 1996, 66:20-40.
65. Schulz R., Beach S.R., Ives D.G., Martire L.M., Ariyo A.A., Kop W.J. Association between depression and mortality in older adults: the Cardiovascular Health Study. Arch. Intern. Med. 2000, 160:1761-1768.
66. Staras S.A.S., Dollard S.C., Radford K.W., Flanders W.D., Pass R.F., Cannon M.J. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin. Infect. Dis. 2006, 43:1143-1151.
67. Stein K.D., Jacobsen P.B., Blanchard C.M., Thors C. Further validation of the multidimensional fatigue symptom inventory-short form. J. Pain Symptom Manage. 2004, 27:14-23.
68. Stewart A.L., Mills K.M., King A.C., Haskell W.L., Gillis D., Ritter P.L. CHAMPS physical activity questionnaire for older adults: outcomes for interventions. Med. Sci. Sports Exerc. 2001, 33:1126-1141.
69. Stewart J.C., Rand K.L., Muldoon M.F., Kamarck T.W. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav. Immun. 2009, 23:936-944.
70. Thornton L.M., Andersen B.L., Blakely W.P. The pain, depression, and fatigue symptom cluster in advanced breast cancer: covariation with the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Health Psychol. 2010, 29:333-337.
71. VanderZee K.I., Sanderman R., Heyink J.W., de Haes H. Psychometric qualities of the RAND 36-Item Health Survey 1.0: a multidimensional measure of general health status. Int. J. Behav. Med. 1996, 3:104-122.
72. Walker E.A., Katon W.J., Jemelka R.P. Psychiatric disorders and medical care utilization among people in the general population who report fatigue. J. Gen. Intern. Med. 1993, 8:436-440.
73. WHO World Health Organization: Initiative for Vaccine Research Viral Cancers - Epstein-Barr Virus 2012, http://www.who.int/vaccine_research/diseases/viral_cancers/en/index1.html.