Hepatocellular toxicity of benzbromarone: Effects on mitochondrial function and structure

Toxicology

Volumn 324, Issue , 2014, Pages 136-146

  Felser, Andrea ^a,b   Lindinger, Peter W ^a,b,c   Schnell, Dominik ^a,b   Kratschmar, Denise V ^b,c   Odermatt, Alex ^b,c   Mies, Suzette ^d   Jenö, Paul ^d   Krähenbühl, Stephan ^a,b,c  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c Swiss Centre for Applied Human Toxicology   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Benzbromarone; Mitochondrial fragmentation; Mitochondrial toxicity; Respiratory chain; oxidation

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZBROMARONE; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE I ALPHA; LACTIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; MITOCHONDRIAL DNA; PALMITIC ACID; PALMITOYLCARNITINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL RESPIRATION; CELL STRUCTURE; DNA CONTENT; DRUG EFFECT; FATTY ACID OXIDATION; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; MITOCHONDRIAL VOLUME; MOUSE; NECROSIS; NERVE CELL NETWORK; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CONTENT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL MODEL; ANIMAL TISSUE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; DRUG EXPOSURE; ENZYME INHIBITION; GLYCOLYSIS; HEPATIC MITOCHONDRIAL TOXICITY; LIVER CELL; LIVER STRUCTURE; MOLECULAR BIOLOGY; STRUCTURE ANALYSIS;

BENZBROMARONE; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL TOXICITY; RESPIRATORY CHAIN; Β-OXIDATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BENZBROMARONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENERGY METABOLISM; GLYCOLYSIS; HEP G2 CELLS; HUMANS; LACTIC ACID; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; NECROSIS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84907318201     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.08.002     Document Type: Article

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