Down-regulating ERK1/2 and SMAD2/3 phosphorylation by physical barrier of celecoxib-loaded electrospun fibrous membranes prevents tendon adhesions

Biomaterials

Volumn 35, Issue 37, 2014, Pages 9920-9929

  Jiang, Shichao ^a   Zhao, Xin ^b   Chen, Shuai ^a   Pan, Guoqing ^b,c   Song, Jialin ^a   He, Ning ^a   Li, Fengfeng ^a   Cui, Wenguo ^b,c   Fan, Cunyi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b SOOCHOW UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Celecoxib; Electrospun fiber; ERK; Phosphorylation; SMAD; Tendon adhesions

Indexed keywords

ADHESION; CELL CULTURE; COLLAGEN; ELECTROSPINNING; FIBROBLASTS; LACTIC ACID; PHOSPHORYLATION; REPAIR; SYNTHESIS (CHEMICAL); TENDONS;

CELECOXIB; ELECTROSPUN FIBERS; ERK; SMAD; TENDON ADHESIONS;

FIBROUS MEMBRANES;

CELECOXIB; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COPOLYMER; MACROGOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYLACTIC ACID; SMAD2 PROTEIN; SMAD3 PROTEIN; ARTIFICIAL MEMBRANE; CYCLOOXYGENASE 2 INHIBITOR; LACTIC ACID DERIVATIVE; MACROGOL DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; POLY(LACTIC ACID-ETHYLENE GLYCOL); PYRAZOLE DERIVATIVE; SMAD PROTEIN; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG RELEASE; ELECTROSPINNING; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PERITENDINOUS ADHENSION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; TENDON DISEASE; TENDON RECONSTRUCTION; TISSUE ADHESION; ANIMAL; ARTIFICIAL MEMBRANE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; TENDON; TISSUE ADHESIONS;

ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; DRUG DELIVERY SYSTEMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; LACTATES; MEMBRANES, ARTIFICIAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; POLYETHYLENE GLYCOLS; PYRAZOLES; RABBITS; SMAD PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; SULFONAMIDES; TENDONS; TISSUE ADHESIONS;

EID: 84907272822     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.08.028     Document Type: Article

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