The threshold shift paradigm of obesity: Evidence from surgically induced weight loss

American Journal of Clinical Nutrition

Volumn 100, Issue 4, 2014, Pages 996-1002

  Ferrannini, Ele ^a   Rosenbaum, Michael ^b   Leibel, Rudolph L ^b  

^a UNIVERSITY OF PISA   (Italy)

^b Columbia University College of Physicians and Surg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGE; ARTICLE; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CALORIC RESTRICTION; COHORT ANALYSIS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; PREDICTIVE VALUE; ROUX Y ANASTOMOSIS; STOMACH BYPASS; SURGICAL PATIENT; WEIGHT REDUCTION; BLOOD; COMPARATIVE STUDY; DIET THERAPY; LOW CALORY DIET; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; STATISTICAL MODEL;

ADULT; ANASTOMOSIS, ROUX-EN-Y; BODY MASS INDEX; COHORT STUDIES; DIET, REDUCING; ENERGY INTAKE; FEMALE; GASTRIC BYPASS; HUMANS; LEPTIN; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PREVALENCE; WEIGHT LOSS;

EID: 84907270847     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.090167     Document Type: Article

References (62)

1. Long-term pharmacotherapy in the management of obesity: National Task Force on the Prevention and Treatment of Obesity. JAMA 1996; 276:1907-15.
2. Elfhag K, Rössner S. Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev 2005;6:67-85.
3. Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, Smith RJ, Smith SR. Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab 2011;96:1654-63.
4. National Task Force on the Prevention and Treatment of Obesity. Dieting and the development of eating disorders in overweight and obese adults. Arch Intern Med 2000;160:2581-9.
5. Rosenbaum M, Leibel RL, Hirsch J. Obesity. N Engl J Med 1997;337: 396-407.
6. Wlodek D, Gonzales M. Decreased energy levels can cause and sustain obesity. J Theor Biol 2003;225:33-44.
7. Guyenet SJ, Schwartz MW. Clinical review: regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 2012;97:745-55.
8. Leibel RL, Rosenbaum M. Metabolic responses to weight perturbation. In: Clément K, et al., eds. Novel insights into adipose cell functions, research and perspectives in endocrine interactions. Berlin, Heidelberg: Springer-Verlag, 2010:121-33.
9. Rosenbaum M, Kissileff HR, Mayer LES, Hirsch J, Leibel RL. Energy intake in weight-reduced humans. Brain Res 2010;1350:95-102.
10. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8.
11. Pankevich DE, Teegarden SL, Hedin AD, Jensen CL, Blale TL. Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating. J Neurosci 2010;30:16399-407.
12. Rosenbaum M, Leibel RL. Adaptive response to weight loss. In: Kushner RF, Bessesen DH, eds. Treatment of the obese patient. 2nd ed. New York, NY: Springer-Verlag New York, LLC (in press).
13. Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, Bantle JP, Sledge I. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122:248-56.
14. Romeo S, Maglio C, Burza MA, Pirazzi C, Sjöholm K, Jacobson P, Svensson PA, Peltonen M, Sjöström L, Carlsson LM. Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes. Diabetes Care 2012;35:2613-7.
15. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357:741-52.
16. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC. Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357:753-61.
17. Stylopoulos N, Davis P, Pettit JD, Rattner DW, Kaplan LM. Changes in serum ghrelin predict weight loss after Roux-en-Y gastric bypass in rats. Surg Endosc 2005;19:942-6.
18. Ikramuddin S, Korner J, Lee WJ, Connett JE, Inabnet WB, Billington CJ, Thomas AJ, Leslie DB, Chong K, Jeffery RW, et al. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. JAMA 2013;309:2240-9.
19. Dixon JB, le Roux CW, Rubino F, Zimmet P. Bariatric surgery for type 2 diabetes. Lancet 2012;379:2300-11.
20. Ochner CN, Laferrere B, Afifi L, Atalayer D, Geleibter A, Texeira J. Neural responsivity to food cues in fasted and fed states pre and post gastric bypass surgery. Neurosci Res 2012;74:138-43.
21. Iesari S, le Roux CS, De Gaetano A, Manco M, Nanni G, Mingrone G. Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric surgery. J Clin Endocrinol Metab 2013;98:E321-7.
22. Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A. RISC Investigators. Natural history and physiological determinants of changes in glucose tolerance in a nondiabetic population: the RISC Study. Diabetologia 2011;54:1507-16.
23. Rebelos E, Muscelli E, Natali A, Balkau B, Mingrone G, Piatti P, Konrad T, Mari A, Ferrannini E; RISC Study Investigators. Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study. Diabetes 2011;60:1938-45.
24. Ferrannini E, Mingrone G. Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diabetes Care 2009;32:514-20.
25. Astiarraga B, Gastaldelli A, Muscelli E, Baldi S, Camastra S, Mari A, Papadia F, Camerini G, Adami G, Scopinaro N, et al. Biliopancreatic diversion in nonobese patients with type 2 diabetes: impact and mechanisms. J Clin Endocrinol Metab 2013;98:2765-73.
26. Strain GW, Wang J, Gagner M, Pomp A, Inabnet WB, Heymsfield SB. Bioimpedance for severe obesity: comparing research methods for total body water and resting energy expenditure. Obesity (Silver Spring) 2008;16:1953-6.
27. Hall KD. Mathematical modelling of energy expenditure during tissue deposition. Br J Nutr 2010;104:4-7.
28. Hall KD. Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrinol Metab 2010;298: E449-66.
29. Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, Gortmaker SL, Swinburn BA. Quantification of the effect of energy imbalance on bodyweight. Lancet 2011;378:826-37.
30. Hall KD. Mechanisms of metabolic fuel selection: modeling human metabolism and body-weight. IEEE Eng Med Biol Mag 2010;29: 36-41.
31. Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Bouchard C, Wilmore JH. The effect of sex, age and race on estimating percentage body fat from body mass index: the Heritage Family Study. Int J Obes Relat Metab Disord 2002;26:789-96.
32. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990;51:241-7.
33. Hall KD. Body fat and fat-free mass inter-relationships: Forbes's theory revisited. Br J Nutr 2007;97:1059-63.
34. Balkau B, Mhamdi L, Oppert JM, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E; EGIR-RISC Study Group. Physical activity and insulin sensitivity: the RISC study. Diabetes 2008;57:2613-8.
35. Martin CK, Heilbronn LK, de Jonge L, de Jonge L, DeLany JP, Volaufova J, Anton SD, Redman LM, Smith SR, Ravussin E. Effect of calorie restriction on resting metabolic rate and spontaneous physical activity. Obesity (Silver Spring) 2007;15:2964-73.
36. Albu JB, Heilbronn LK, Kelley DE, DeLany JP, Volaufova J, Anton SD, Redman LM, Smith SR, Ravussin E. Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes. Diabetes 2010;59:627-33.
37. Heo M. Faith MS, Pietrobelli A. Resistance to change of adulthood body mass index. Int J Obes Relat Metab Disord 2002;26:1404-5.
38. Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, Delany JP, Ravussin E; Pennington CALERIE Team. Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS ONE 2009;4:e4377.
39. Nicklas JM, Huskey KW, Davis RB, Wee CC. Successful weight loss among obese U.S. adults. Am J Prev Med 2012;42:481-5.
40. Christiansen E, Garby L. Prediction of body weight changes caused by changes in energy balance. Eur J Clin Invest 2002;32:826-30.
41. Laurenius A, Larsson I, Bueter M, Melanson KJ, Bosaeus I, Forslund HB, Lönroth H, Fändriks L, Olbers T. Changes in eating behaviour and meal pattern following Roux-en-Y gastric bypass. Int J Obes (Lond) 2012;36:348-55.
42. Ortega J, Ortega-Evangelio G, Cassinello N, Sebastia V. What are obese patients able to eat after Roux-en-Y gastric bypass? Obes Facts 2012;5:339-48.
43. Laurenius A, Larsson I, Melanson KJ, Lindroos AK, Lönroth H, Bosaeus I, Olbers T. Decreased energy density and changes in food selection following Roux-en-Y gastric bypass. Eur J Clin Nutr 2013; 67:168-73.
44. Johannsen DL, Knuth ND, Huizenga R, Rood JC, Ravussin E, Hall KD. Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab 2012;97:2489-96.
45. Carrasco F, Papapietro K, Csendes A, Salazar G, Echenique C, Lisboa C, Díaz E, Rojas J. Changes in resting energy expenditure and body composition after weight loss following Roux-en-Y gastric bypass. Obes Surg 2007;17:608-16.
46. Thivel D, Brakonieki K, Duche P, Morio B, Boirie Y, Laferrère B. Surgical weight loss: impact on energy expenditure. Obes Surg 2013;23:255-66.
47. Werling M, Olbers T, Fändriks L, Bueter M, Lönroth H, Stenlöf K, le Roux CW. Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty. PLoS ONE 2013;8:e60280.
48. Wilms B, Ernst B, Schmid SM, Thurnheer M, Schultes B. Enhanced thermic effect of food after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab 2013;98:3776-84.
49. Scopinaro N, Marinari GM, Pretolesi F, Papadia F, Murelli F, Marini P, Adami GF. Energy and nitrogen absorption after biliopancreatic diversion. Obes Surg 2000;10:436-41.
50. Cornicelli M, Noli G, Marinari GM, Adami GF. Dietary habits and body weight at long-term following biliopancreatic diversion. Obes Surg 2010;20:1278-80.
51. Mendieta-Zerón H, Larrad-Jiménez Á, Rodríguez MM, Da Boit K, Frühbeck G, Diéguez C. Biliopancreatic diversion induces villi elongation and cholecystokinin and ghrelin increase. Diabetes Metab Syndr 2011;5:66-70.
52. Scopinaro N. Biliopancreatic diversion: mechanisms of action and long-term results. Obes Surg 2006;16:683-9.
53. Scopinaro N. Thirty-five years of biliopancreatic diversion: notes on gastrointestinal physiology to complete the published information useful for a better understanding and clinical use of the operation. Obes Surg 2012;22:427-32.
54. Breen DM, Rasmussen BA, Kokorovic A, Wang R, Cheung GW, Lam TK. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med 2012;18:950-5.
55. Leibel RL. The role of leptin in the control of body weight. Nutr Rev 2002;60:S15-9.
56. Könner AC, Brüning JC. Selective insulin and leptin resistance in metabolic disorders. Cell Metab 2012;16:144-52.
57. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999;282:1568-75.
58. Korner J, Conroy R, Febres G, McMahon DJ, Conwell I, Karmally W, Aronne LJ. Randomized double-blind placebo-controlled study of leptin administration after gastric bypass. Obesity (Silver Spring) 2013; 21:951-6.
59. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. Low dose leptin administration reverses effects of sustained weightreduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 2002;87:2391-4.
60. Ryan KK, Woods SC, Seeley RJ. Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab 2012;15:137-49.
61. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005;115:3579-86.
62. Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL. Is the energy homeostasis system inherently biased toward weight gain? Diabetes 2003;52:232-8.