Structure of an agonist-bound ionotropic glutamate receptor

Science

Volumn 345, Issue 6200, 2014, Pages 100-1074

  Yelshanskaya, Maria V ^a   Li, Minfen ^a   Sobolevsky, Alexander I ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CYSTEINE; FANAPANEL; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; ION CHANNEL; IONOTROPIC RECEPTOR; 5 NITROWILLARDIINE; 5-NITROWILLARDIINE; CROSS LINKING REAGENT; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; GLUTAMIC ACID; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINOXALINE DERIVATIVE;

BIOASSAY; BIOENGINEERING; METABOLISM; NERVOUS SYSTEM; NEUROLOGY; ORGANIC COMPOUND; PHYSIOLOGICAL RESPONSE; PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BIOCHEMISTRY; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ELECTROPHYSIOLOGY; HEK293 CELL LINE; HUMAN; KINETICS; MOLECULAR MECHANICS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DRUG POTENTIATION; GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

RATTUS;

ANIMALS; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; GLUTAMIC ACID; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MODELS, CHEMICAL; ORGANOPHOSPHONATES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINONES; QUINOXALINES; RATS; RECEPTORS, AMPA;

EID: 84907261409     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1256508     Document Type: Article

References (37)

1. S. F. Traynelis et al., Pharmacol. Rev. 62, 405-496 (2010).
2. D. Bowie, CNS Neurol. Disord. Drug Targets 7, 129-143 (2008).
3. P. Paoletti, C. Bellone, Q. Zhou, Nat. Rev. Neurosci. 14, 383-400 (2013).
4. Z. Galen Wo, R. E. Oswald, Trends Neurosci. 18, 161-168 (1995).
5. A. I. Sobolevsky, M. P. Rosconi, E. Gouaux, Nature 462, 745-756 (2009).
6. C. H. Lee et al., Nature 511, 191-197 (2014).
7. E. Karakas, H. Furukawa, Science 344, 992-997 (2014).
8. M. V. Jones, G. L. Westbrook, Trends Neurosci. 19, 96-101 (1996).
9. M. D. Black, Psychopharmacology (Berl.) 179, 154-163 (2005).
10. D. K. Patneau, L. Vyklicky Jr., M. L. Mayer, J. Neurosci. 13, 3496-3509 (1993).
11. R. Jin, T. G. Banke, M. L. Mayer, S. F. Traynelis, E. Gouaux, Nat. Neurosci. 6, 803-810 (2003).
12. K. Poon, L. M. Nowak, R. E. Oswald, Biophys. J. 99, 1437-1446 (2010).
13. K. Poon, A. H. Ahmed, L. M. Nowak, R. E. Oswald, Mol. Pharmacol. 80, 49-59 (2011).
14. A. Robert, N. Armstrong, J. E. Gouaux, J. R. Howe, J. Neurosci. 25, 3752-3762 (2005).
15. R. Jin et al., EMBO J. 28, 1812-1823 (2009).
16. K. Menuz, R. M. Stroud, R. A. Nicoll, F. A. Hays, Science 318, 815-817 (2007).
17. N. Armstrong, E. Gouaux, Neuron 28, 165-181 (2000).
18. N. Armstrong, J. Jasti, M. Beich-Frandsen, E. Gouaux, Cell 127, 85-97 (2006).
19. A. S. Maltsev, A. H. Ahmed, M. K. Fenwick, D. E. Jane, R. E. Oswald, Biochemistry 47, 10600-10610 (2008).
20. A. J. Plested, M. L. Mayer, J. Neurosci. 29, 11912-11923 (2009).
21. M. K. Fenwick, R. E. Oswald, J. Biol. Chem. 285, 12334-12343 (2010).
22. C. F. Landes, A. Rambhadran, J. N. Taylor, F. Salatan, V. Jayaraman, Nat. Chem. Biol. 7, 168-173 (2011).
23. A. Y. Lau, B. Roux, Nat. Struct. Mol. Biol. 18, 283-287 (2011).
24. P. A. Postila, M. Ylilauri, O. T. Pentikäinen, J. Chem. Inf. Model. 51, 1037-1047 (2011).
25. S. Ramaswamy et al., J. Biol. Chem. 287, 43557-43564 (2012).
26. A. H. Ahmed et al., J. Biol. Chem. 288, 27658-27666 (2013).
27. Y. Yao, J. Belcher, A. J. Berger, M. L. Mayer, A. Y. Lau, Structure 21, 1788-1799 (2013).
28. Y. Stern-Bach, S. Russo, M. Neuman, C. Rosenmund, Neuron 21, 907-918 (1998).
29. Y. Sun et al., Nature 417, 245-253 (2002).
30. W. Zhang, Y. Cho, E. Lolis, J. R. Howe, J. Neurosci. 28, 932-943 (2008).
31. A. H. Ahmed, S. Wang, H. H. Chuang, R. E. Oswald, J. Biol. Chem. 286, 35257-35266 (2011).
32. D. M. MacLean, A. Y. Wong, A. M. Fay, D. Bowie, J. Neurosci. 31, 2136-2144 (2011).
33. M. C. Weston, C. Gertler, M. L. Mayer, C. Rosenmund, J. Neurosci. 26, 7650-7658 (2006).
34. A. L. Carbone, A. J. Plested, Neuron 74, 845-857 (2012).
35. C. R. Midgett, A. Gill, D. R. Madden, Front. Mol. Neurosci. 4, 56 (2012).
36. A. Y. Lau et al., Neuron 79, 492-503 (2013).
37. D. M. Schauder et al., Proc. Natl. Acad. Sci. U.S.A. 101, 5921-5926 (2013).