Acute effect of Ceylon cinnamon extract on postprandial glycemia: Alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Beejmohun, Vickram ^a   Peytavy Izard, Marie ^a   Mignon, Cyril ^a   Muscente Paque, Delphine ^b   Deplanque, Xavier ^b   Ripoll, Christophe ^b   Chapal, Nicolas ^a  

^a Parc Agropolis 2   (France)

^b Naturalpha SAS   (France)

Author keywords

Alpha amylase inhibitor; Cinnamon extract; Glycemic index; Metabolic syndrome; Postprandial glycemia; Pre diabetes; Starch digestion

Indexed keywords

ALPHA AMYLASE PANCREAS ISOENZYME; AMYLASE; AMYLASE INHIBITOR; ANTIDIABETIC AGENT; CEYLON CINNAMON AQUEOUS EXTRACT; CEYLON CINNAMON HYDRO ALCOHOLIC EXTRACT; CINNAMON EXTRACT; GLUCOSE; INSULIN; PLACEBO; STARCH; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

ABSENCE OF SIDE EFFECTS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CINNAMON; COMPARATIVE EFFECTIVENESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MALE; NONHUMAN; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; RANDOMIZED CONTROLLED TRIAL; RAT; STARCH TOLERANCE TEST; TEST MEAL; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CINNAMOMUM ZEYLANICUM; DRUG EFFECTS; METABOLISM; POSTPRANDIAL STATE; WISTAR RAT;

ADULT; ALPHA-AMYLASES; ANIMALS; BLOOD GLUCOSE; CINNAMOMUM ZEYLANICUM; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; MALE; PLANT EXTRACTS; POSTPRANDIAL PERIOD; RATS; RATS, WISTAR; STARCH;

EID: 84907260493     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-351     Document Type: Article

References (33)

1. International Diabetes Federation - Guideline for management of postmeal glucose. http://www.idf.org/2011-guideline-management-postmeal-glucose-diabetes.
2. Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, Brand-Miller JC. Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies. Am J Clin Nutr 2008, 87(3):627-637.
3. Monnier L, Benichou M, Charra-Ebrard S, Boegner C, Colette C. An overview of the rationale for pharmacological strategies in type 2 diabetes: from the evidence to new perspectives. Diabetes Metab 2005, 31(2):101-109. 10.1016/S1262-3636(07)70174-X, 15959415.
4. Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 2003, 26(3):881-885. 10.2337/diacare.26.3.881, 12610053.
5. Monnier L, Colette C, Dunseath GJ, Owens DR. The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes. Diabetes Care 2007, 30(2):263-269. 10.2337/dc06-1612, 17259492.
6. de Rougemont A, Normand S, Nazare JA, Skilton MR, Sothier M, Vinoy S, Laville M. Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects. Br J Nutr 2007, 98(6):1288-1298.
7. Bouche C, Rizkalla SW, Luo J, Vidal H, Veronese A, Pacher N, Fouquet C, Lang V, Slama G. Five-week, low-glycemic index diet decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men. Diabetes Care 2002, 25(5):822-828. 10.2337/diacare.25.5.822, 11978675.
8. McMillan-Price J, Petocz P, Atkinson F, O'Neill K, Samman S, Steinbeck K, Caterson I, Brand-Miller J. Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Arch Intern Med 2006, 166(14):1466-1475. 10.1001/archinte.166.14.1466, 16864756.
9. Jenkins DJ, Wolever TM, Kalmusky J, Giudici S, Giordano C, Wong GS, Bird JN, Patten R, Hall M, Buckley G, Little JA. Low glycemic index carbohydrate foods in the management of hyperlipidemia. Am J Clin Nutr 1985, 42(4):604-617.
10. Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Esposito K, Giugliano D. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes 2004, 53(3):701-710. 10.2337/diabetes.53.3.701, 14988255.
11. Hanefeld M, Koehler C, Schaper F, Fuecker K, Henkel E, Temelkova-Kurktschiev T. Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individuals. Atherosclerosis 1999, 144(1):229-235. 10.1016/S0021-9150(99)00059-3, 10381296.
12. Philippou E, McGowan BM, Brynes AE, Dornhorst A, Leeds AR, Frost GS. The effect of a 12-week low glycaemic index diet on heart disease risk factors and 24 h glycaemic response in healthy middle-aged volunteers at risk of heart disease: a pilot study. Eur J Clin Nutr 2008, 62(1):145-149. 10.1038/sj.ejcn.1602688, 17311054.
13. Hanefeld M, Cagatay M, Petrowitsch T, Neuser D, Petzinna D, Rupp M. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur Heart J 2004, 25(1):10-16. 10.1016/S0195-668X(03)00468-8, 14683737.
14. Blake DR, Meigs JB, Muller DC, Najjar SS, Andres R, Nathan DM. Impaired glucose tolerance, but not impaired fasting glucose, is associated with increased levels of coronary heart disease risk factors: results from the Baltimore Longitudinal Study on Aging. Diabetes 2004, 53(8):2095-2100. 10.2337/diabetes.53.8.2095, 15277391.
15. Derosa G, Maffioli P. Efficacy and safety profile evaluation of acarbose alone and in association with other antidiabetic drugs: a systematic review. Clin Therapeut 2012, 34(6):1221-1236.
16. Pan CY. Reducing the risk of type 2 diabetes: early identification of high-risk individuals and treatment with acarbose. Curr Diabetes Rev 2007, 3(2):141-148. 10.2174/157339907780598243, 18220665.
17. O'Keefe JH, Gheewala NM, O'Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 2008, 51(3):249-255. 10.1016/j.jacc.2007.10.016, 18206731.
18. Woehrlin F, Fry H, Abraham K, Preiss-Weigert A. Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from Indonesia. J Agric Food Chem 2010, 58(19):10568-10575. 10.1021/jf102112p, 20853872.
19. Abraham K, Wohrlin F, Lindtner O, Heinemeyer G, Lampen A. Toxicology and risk assessment of coumarin: focus on human data. Mol Nutr Food Res 2010, 54(2):228-239. 10.1002/mnfr.200900281, 20024932.
20. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003, 26(12):3215-3218. 10.2337/diacare.26.12.3215, 14633804.
21. Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 2006, 136(4):977-980.
22. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006, 36(5):340-344. 10.1111/j.1365-2362.2006.01629.x, 16634838.
23. Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res 2012, 32(6):408-412. 10.1016/j.nutres.2012.05.003, 22749176.
24. Akilen R, Tsiami A, Devendra D, Robinson N. Cinnamon in glycaemic control: systematic review and meta analysis. Clin Nutr 2012, 31(5):609-615. 10.1016/j.clnu.2012.04.003, 22579946.
25. Rafehi H, Ververis K, Karagiannis TC. Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Diabetes Obes Metabol 2012, 14(6):493-499.
26. Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care 2008, 31(1):41-43.
27. Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K. Cinnamon extract inhibits alpha-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab 2011, 8(1):46.
28. Wickenberg J, Lindstedt S, Berntorp K, Nilsson J, Hlebowicz J. Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance. Br J Nutr 2012, 107(12):1845-1849. 10.1017/S0007114511005113, 21929834.
29. Markey O, McClean CM, Medlow P, Davison GW, Trinick TR, Duly E, Shafat A. Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovasc Diabetol 2011, 10:78. 10.1186/1475-2840-10-78, 3180260, 21899741.
30. Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr 2007, 85(6):1552-1556.
31. Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr 2009, 89(3):815-821. 10.3945/ajcn.2008.26807, 19158209.
32. Magistrelli A, Chezem JC. Effect of ground cinnamon on postprandial blood glucose concentration in normal-weight and obese adults. J Acad Nutr Diet 2012, 112(11):1806-1809. 10.1016/j.jand.2012.07.037, 23102179.
33. Koch GG. The use of non-parametric methods in the statistical analysis of the two-period change-over design. Biometrics 1972, 28(2):577-584. 10.2307/2556170, 4556704.