Cinnamon in glycaemic control: Systematic review and meta analysis

Clinical Nutrition

Volumn 31, Issue 5, 2012, Pages 609-615

  Akilen, Rajadurai ^a   Tsiami, Amalia ^a   Devendra, Devasenan ^b   Robinson, Nicola ^c  

^a UNIVERSITY OF WEST LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c LONDON SOUTH BANK UNIVERSITY   (United Kingdom)

Author keywords

Blood glucose; Cinnamon; Diabetes; Dietary supplement; HbA1c; Nutrition

Indexed keywords

CINNAMOMUM CASSIA EXTRACT; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

CHOLESTEROL BLOOD LEVEL; CINNAMOMUM CASSIA; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

BIOLOGICAL AGENTS; BLOOD GLUCOSE; CINNAMOMUM ZEYLANICUM; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; GLYCEMIC INDEX; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; PLANT EXTRACTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84866616033     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2012.04.003     Document Type: Review

References (30)

1. Khan A., Safdar M., li Khan M.M., Khattak K.N., Anderson R.A. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003, 26(12):3215-3218.
2. Mang B., Wolters M., Schmitt B., Kelb K., Lichtinghagen R., Stichtenoth D.O., et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006, 36(5):340-344.
3. Verspohl E.J., Bauer K., Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res 2005, 19(3):203-206.
4. Blevins S.M., Leyva M.J., Brown J., Wright J., Scofield R.H., Aston C.E. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care 2007, 30(9):2236-2237.
5. Vanschoonbeek K., Thomassen B.J., Senden J.M., Wodzig W.K., van Loon L.J. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 2006, 136(4):977-980.
6. Altschuler J.A., Casella S.J., MacKenzie T.A., Curtis K.M. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007, 30(4):813-816.
7. Solomon T.P., Blannin A.K. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab 2007, 19(6):895-901.
8. Ziegenfuss T.N., Hofheins J.E., Mendel R.W., Landis J., Anderson R.A. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr 2006, 3:45-53.
9. Anderson R.A. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc 2008, 67(1):48-53.
10. Broadhurst C.L., Polansky M.M., Anderson R.A. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000, 48(3):849-852.
11. Cao H., Polansky M.M., Anderson R.A. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys 2007, 459(2):214-222.
12. Imparl-Radosevich J., Deas S., Polansky M.M., Baedke D.A., Ingebritsen T.S., Anderson R.A., et al. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm Res 1998, 50(3):177-182.
13. Jarvill-Taylor K., Anderson R.A., Graves O.J. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001, 20(4):327-336.
14. Kim W., Khil L.Y., Clark R., Bok S.H., Kim E.E., Lee S., et al. Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4. Diabetologia 2006, 49(10):2437-2448.
15. Anderson R.A., Broadhurst C.L., Polansky M.M., Schmidt W.F., Khan A., Flanagan V.P., et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004, 52(1):65-70.
16. Baker W.L., Gutierrez-Williams G., White C.M., Kluger J., Coleman C.I. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care 2008, 31(1):41-43.
17. Kirkham S., Akilen R., Sharma S., Tsiami A. The potential of cinnamon to reduce blood glucose levels in patients with diabetes. Diabetes Obes Metab 2009, 11(12):1100-1113.
18. Pham A.Q., Kourlas H., Pham D.Q. Cinnamon supplementation in patients with type 2 diabetes mellitus. Pharmacotherapy 2007, 27(4):595-599.
19. Hlebowicz J., Hlebowicz A., Lindstedt S., Bjorgell O., Hoglund P., Holst J.J. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr 2009, 89:815-821.
20. Hlebowicz J., Darwiche G., Bjorgell O., Almer L.O. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr 2007, 85(6):1552-1556.
21. Solomon T.P., Blannin A.K. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol 2009, 105:969-976.
22. Tang M., Larson-Meyer D.E., Liebman M. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. Am J Clin Nutr 2008, 87:1262-1267.
23. Wang J.G., Anderson R.A., Graham G.M., Chu M.C., Sauer M.V., Guarnaccia M.M. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril 2007, 88:240-243.
24. Roussel A.M., Hininger I., Benaraba R., Ziegenfuss T.N., Anderson R.A. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr 2009, 28:16-21.
25. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009, 22:507-512.
26. Akilen R., Tsiami A., Devendra D., Robinson N. Glycated Haemoglobin and blood Pressure lowering effect of cinnamon in Multi ethnic type 2 diabetic patients in UK; A randomized, placebo controlled, double blind clinical trial. Diabet Med 2010, 27:1159-1167.
27. American Diabetes Association Standards of medical care in diabetes. Diabetes Care 2005, 28(1):S4-S36.
28. American Diabetes Association Standards of medical care in diabetes. Diabetes Care 2006, 29:S4-S42.
29. Pessin J.E., Saltiel A.R. Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 2000, 106(2):165-169.
30. Shepherd P., Kahn B. Glucose transporters and insulin action. New Engl J Med 1999, 248-258.