Elevated cell-free plasma DNA level as an independent predictor of mortality in patients with severe traumatic brain injury

Journal of Neurotrauma

Volumn 31, Issue 19, 2014, Pages 1639-1646

  Rodrigues Filho, Edison Moraes ^a   Simon, Daniel ^a   Ikuta, Nilo ^a,b   Klovan, Caroline ^a   Dannebrock, Fernando Augusto ^a   Oliveira De Oliveira, Carla ^a   Regner, Andrea ^a  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b Simbios Biotecnologia   (Brazil)

Author keywords

biomarkers; outcome; plasma DNA; real time PCR; traumatic brain injury

Indexed keywords

DNA; PLASMA DNA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; ARTICLE; BETA GLOBIN GENE; BLOOD SAMPLING; CELL FREE SYSTEM; CONTROLLED STUDY; DEATH; FATALITY; FEMALE; GENE; GLASGOW COMA SCALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INJURY SEVERITY; INTENSIVE CARE UNIT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SURVIVAL; TRAUMATIC BRAIN INJURY; AREA UNDER THE CURVE; BLOOD; BRAIN INJURY; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC;

ADULT; AREA UNDER CURVE; BIOLOGICAL MARKERS; BRAIN INJURIES; DNA; FEMALE; GLASGOW COMA SCALE; HUMANS; MALE; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84907236810     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.3178     Document Type: Article

References (55)

1. Faul, M., Xu, L., Wald, M.M., and Coronado, V. (2010). Traumatic brain injury in the United States: Emergency department visits, hospitalizations, and deaths, 2002-2006. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control: Atlanta, GA
2. Coronado, V.G., Xu, L., Basavaraju, S.V., Mcguire, L.C., Wald, M.M., Faul, M.D., Guzman, B.R., and Hemphill, J.D; Centers for Disease Control and Prevention. (2011). Surveillance for traumatic brain injury-related deaths-United States, 1997-2007. MMWR Surveil Summ 60, 1-32
3. Zaloshnja, E., Miller, T., Langlois, JA., and Selassie, AW. (2008). Prevalence of long-Term disability from traumatic brain injury in the civilian population of the United States, 2005. J. Head Trauma Rehab. 23, 394-400
4. Woertgen, C., Rothoerl, RD., Metz, C., and Brawanski, A. (1999). Comparison of clinical, radiologic, and serum marker as prognostic factors after severe head injury. J. Trauma 47, 1126-1130
5. Pelinka, LE., Toegel, E., Mauritz, W., and Redl, H. (2003). Serum S 100B: a marker of brain Damage in traumatic brain injury with and without multiple trauma. Shock 19, 195-200
6. Toschlog, E.A., MacElligot, J., Sagraves, S.G., Schenarts, P.J., Bard, M.R., Goettler, C.E., Rotondo, M.F., and Swanson, M.S. (2003). The relationship of Injury Severity Score and Glasgow Coma Score to rehabilitative potential in patients suffering traumatic brain injury. Am. Surg. 69, 491-498
7. Ghajar, J. (2000). Traumatic brain injury. Lancet 356, 923-929
8. Townend, W.J., Guy, M.J., Pani, M.A., Martin, B., and Yates, D.W. (2002). Head injury outcome prediction in the emergency department: a role for protein S-100B?. J. Neurol. Neurosurg. Psychiatry 73, 542-546
9. Coplin, W.M. (2001). Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale and protocol for a randomized clinical trial. Neurol. Res. 23, 277-290
10. Raabe, A., Grolms, C., Sorge, O., Zimmermann, M., and Seifert, V. (1999). Serum S-100B protein in severe head injury. Neurosurgery 45, 477-483
11. Raabe, A., Kopetsch, O., Woszczyk, A., Lang, J., Gerlach, R., Zimmermann, M., and Seifert, V. (2003). Serum S-100B protein as a molecular marker in severe traumatic brain injury. Restor. Neurol. Neurosci. 21, 159-169
12. Herrmann, M., Curio, N., Jost, S., Grubich, C., Ebert, A.D., Fork, M.L., and Synowitz, H. (2001). Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury. J. Neurol. Neurosurg. Psychiatry, 70, 95-100
13. Regner, A., Kaufman, M., Friedman, G., and Chemale, I. (2001). Increased serum S100beta protein concentrations following severe head injury in humans: a biochemical marker of brain Death?. Neuroreport 12, 691-694
14. Petzold, A., Green, A.J., Keir, G., Fairley, S., Kitchen, N., Smith, M., and Thompson, E.J. (2002). Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit. Care Med. 30, 2705-2710
15. Mussack, T., Biberthaler, P., Kanz, K.G., Wiedmann, E., Gippner-Steppert, C., Mutschler, W., and Jochum, M. (2002). Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit. Care Med. 30, 2669-2674
16. Pelinka, L.E., Kroepfl, A., Schmidhammer, R., Krenn, M., Buchinger, W., Redl, H., and Raabe, A. (2004). Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma. J. Trauma 57, 1006-1012
17. Savola, O., Pythinen, J., Leino, T.K., Siitonen, S., Niemela, O., and Hillbom, M. (2004). Effects of head and extracranial injuries on serum protein S100B levels in trauma patients. J. Trauma 56, 1229-1234
18. da Rocha, A.B., Zanoni, C., de Freitas, G.R., André, C., Himelfarb, S., Schneider, R.F., Grivicich, I., Borges, L., Schwartsmann, G., Kaufmann, M., and Regner, A. (2005). Serum Hsp70 as an early predictor of fatal outcome after severe traumatic brain injury in males. J. Neurotrauma 22, 966-977
19. da Rocha, A.B., Schneider, R.F., de Freitas, G.R., André, C., Grivicich, I., Zanoni, C., Fossá, A., Gehrke, J.T, Pereira Jotz, G., Kaufmann, M., Simon, D., and Regner, A. (2006). Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males. Clin. Chem. Lab. Med. 44, 1234-1242
20. Crespo, A.R., Rocha, A.B., Jotz, G.P., Schneider, R.F., Grivicich, I., Pinheiro, K., Zanoni, C., and Regner, A. (2007). Increased serum sFas and TNFa following isolated severe head injury in males. Brain Inj. 21, 441-447
21. de Oliveira, C.O., Reimer, A.G., da Rocha, A.B., Grivicich, I., Schneider, R.F., Roisenberg, I., Regner, A., and Simon, D. (2007). Plasma von Willebrand factor levels correlate with clinical outcome of severe traumatic brain injury. J. Neurotrauma 24, 1331-1338
22. Campello Yurgel, V., Ikuta, N., Brondani da Rocha, A., Lunge, V.R., Fett Schneider, R., Kazantzi Fonseca, A.S., Grivicich, I., Zanoni, C., and Regner, A. (2007). Role of plasma DNA as a predictive marker of fatal outcome following severe head injury in males. J. Neurotrauma 24, 1172-1181
23. Rodrigues, E., Oliveira, C., Cambrussi, A., Gomes, G., Godoy, D., da Rocha, A.B., Grivicich, I., and Regner, A. (2008). Increased serum brain Derived neurotrophic factor (BDNF) following isolated severe traumatic brain injury in humans. Brain Inj. 22, Suppl 1, 165
24. Hergenroeder, G.W., Redell J.B., Moore A.N., and Dash P.K. (2008). Biomarkers in the clinical diagnosis and management of traumatic brain injury. Mol. Diagn. Ther. 12, 345-358
25. Papa L., Akinyi L., Liu, M.C., Pineda, J.A., Tepas, J.J., Oli, M.W., Zheng, W., Robinson, G., Robicsek, S.A., Gabrielli, A., Heaton, S.C., Hannay, H.J., Demery, J.A., Brophy, G.M., Layon, J., Robertson, C.S., Hayes, R.L., and Wang, K.K. (2010). Ubiquitin c-Terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit. Care Med. 38, 138-144
26. Svetlov, S.I., Larner, S.F., Kirk, D.R., Atkinson, J., Hayes, R.L., and Wang, K.K. (2009). Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury. J. Neurotrauma 26, 913-921
27. Macher, H., Egea-Guerrero, J.J., Revuelto-Rey, L., Gordillo-Escobar, E., Enamorado-Enamorado, J., Boza, A., Rodriguez, A., Molinero, P., Guerrero, J.M., Dominguez-Roldán, J.M., Murillo-Cabezas, F., and Rubio, A. (2012). Role of early cell-free DNA levels decreased as a predictive marker of fatal outcome after severe traumatic brain injury. Clin. Chim. Acta, 414, 12-17
28. Schneider Soares, F.M., Menezes d Souza, N., Liborio Schwarzbold, M., Paim Diaz, A., Costa Nunes, J., Hohl, A., Nunes Abreu da Silva, P., Vieira, J., Lisboa de Souza, R., Moré Bertotti, M., Schoder Prediger R.D., Neves Linhares, M., Bafica, A., and Walz, R. (2012). Interleukin-10 is an independent biomarker of severe traumatic brain injury prognosis. Neuroimmunomodulation 19, 377-385
29. Mandel, P., and Metais, P. (1948). Les acides nucleiques du plasma sanguin chez l'homme. C. R. Acad. Sci. Paris, 142, 241-243
30. Lo, Y.M., Corbetta, N., Chamberlain, P.F., Rai, V., Sargent, I.L., Redman, C.W., and Wainscoat, JS. (1997) Presence of fetal DNA in maternal plasma and serum. Lancet 350, 485-487
31. Lo, Y.M., Tein, M.S., Pang, C.C., Yeung, C.K., Tong, K.L., and Hjelm, NM. (1998). Presence of donor-specific DNA in plasma of kidney and liver-Transplant recipients. Lancet 351, 1329-1330
32. Lo, Y.M., Tein, M.S., Lau, T.K., Haines, C.J., Leung, T.N., Poon, P.M., Wainscoat, J.S., Johnson, P.J., Chang, A.M., and Hjelm, N.M. (1998). Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am. J. Hum. Genet. 62, 768-775
33. Johnson, P.J., and Lo, Y.M. (2002). Plasma nucleic acids in the diagnosis and management of malignant disease. Clin. Chem. 48, 1186-1193
34. Wang, B.G., Huang, H., Chen, Y., Bristow, R.E., Kassauei, K., Cheng, C., Roden, R., Skoll, L.J., Chan, D.W., and Shih, IeM. (2003). Increased plasma DNA integrity in cancer patients. Cancer Res. 63, 3966-3968
35. Rainer, T.H., Wong, L.K., Lam, W., Yuen, E., Lam, N.Y., Metreweli, C., and Lo, Y.M. (2003). Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin. Chem. 49, 562-569
36. Rhodes, A., Wort S.J., Thomas, H., Collinson, P., and Bennett, E.D. (2006). Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit. Care 10, R60
37. Rainer, T.H., Lam, N.Y., Man, C.Y., Chiu, R.W., Woo, K.S., and Lo, Y.M. (2006). Plasma beta-globin DNA as a prognostic marker in chest pain patients. Clin. Chim. Acta. 368, 110-113
38. Saukkonen, K., Lakkisto, P., Pettilä, V., Varpula, M., Karlsson, S., Ruokonen, E., and Pulkki, K.; Finnsepsis Study Group. (2008). Cellfree plasma DNA as a predictor of outcome in severe sepsis and septic shock. Clin. Chem. 54, 1000-1007
39. Arnalich, F., Menéndez, M., Lagos, V., Ciria, E., Quesada, A., Codoceo, R., Vazquez, J.J., López-Collazo, E., and Montiel, C. (2010). Prognostic value of cell-free plasma DNA in patients with cardiac arrest outside the hospital: an observational cohort study. Crit. Care 14, R47
40. Lo, Y.M., Rainer, T.H., Chan, L.Y., Hjelm, N.M., and Cocks, R.A. (2000). Plasma DNA as a prognostic marker in trauma patients. Clin. Chem. 46, 319-323
41. Lam, N.Y., Rainer, T.H., Chan, l.Y.S., Joynt, G.M., and Lo, Y.M. (2003). Time course of early and late changes in plasma DNA in trauma patients. Clin. Chem. 49, 1286-1291
42. Boom, R., Sol, C.J., Salimans, M.M., Jansen, C.L., Wertheim-van Dillen, P.M, and Van Der Noordaa, J. (1990). Rapid and simple method for purification of nucleic acids. J. Clin. Microbiol. 28, 495-503
43. Heid, C.A., Stevens, J., Livak, K.J., and Williams, P.M. (1996). Real time quantitative PCR. Genome Res. 6, 986-994
44. Holland, P.M., Abramson, R.D., Watson, R., and Gelfand, D.H. (1991). Detection of specific polymerase chain reaction product by utilizing the 5¢-3¢ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 88, 7276-7280
45. Lam, N.Y., Rainer, T.H., Chiu, R.W., Joynt, G.M., and Lo, Y.M. (2004). Plasma mitochondrial DNA concentrations after trauma. Clin. Chem. 50, 213-216
46. Jahr, S., Hentze, H., Englisch, S., Hardt, D., Fackelmayer, F.O., Hesch, R.D., and Knippers, R. (2001). DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61, 1659-1665
47. Gahan, P.B., Anker, P., and Stroun, M. (2008). Metabolic DNA as the origin of spontaneously released DNA?. Ann. N.Y. Acad. Sci. 1137, 7-17
48. Van Der Vaart, M., and Pretorius, P.J. (2008). Circulating DNA. Its origin and fluctuation. Ann. N.Y. Acad. Sci. 1137, 18-26
49. Lo, Y.M., Zhang, J., Leung, T.N., Lau, T.K., Chang, A.M., and Hjelm, N.M. (1999). Rapid clearance of fetal DNA from maternal plasma. Am. J. Hum. Genet. 64, 218-224
50. Teasdale, G., and Jennett, B. (1974). Assessment of coma and impaired consciousness: a practical scale. Lancet 2, 81-84
51. Zafonte, R.D., Hammond, F.M., Mann, N.R., Wood, D.L., Black, K.L., and Millis, S.R. (1996). Relationship between Glasgow coma scale and functional outcome. Am. J. Phys. Med. Rehabil. 75, 364-369
52. Diringer, M.N., and Edwards, D.F. (1997). Does modification of the Innsbruck and the Glasgow Coma Scales improve their ability to predict functional outcome?. Arch. Neurol. 54, 606-611
53. Balestreri, M., Czosnyka, M., Chatfield, D.A., Steiner, L.A., Schmidt, E.A., Smielewski, P., Matta, B., and Pickard, J.D. (2004). Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years. J. Neurol. Neurosurg. Psychiatry 75, 161-162
54. van Leeuwen, N., Lingsma, H.F., Perel, P., Lecky, P., Roozenbeek, B., Lu, J., Shakur, H., Weir, J., Steyerberg, E.W., and Maas, A.I. (2012). Prognostic value of major extracranial injury in traumatic brain injury: an individual patient data meta-Analysis in 39,274 patients. Neurosurgery 70, 811-818
55. Andriessen, T.M., Horn, J., Franchsman, G., van Der Naalt, J., Haitsma, I., Jacobs, B., Steyerberg, E.W., and Vos P.E. (2011). Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study. J. Neurotrauma 28, 2019-2031