Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death

FASEB Journal

Volumn 28, Issue 9, 2014, Pages 3891-3905

  Cook, Katherine L ^a   Clarke, Pamela A G ^a   Parmar, Jignesh ^b   Hu, Rong ^a   Schwartz Roberts, Jessica L ^a   Abu Asab, Mones ^d   Wärri, Anni ^a   Baumann, William T ^c   Clarke, Robert ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c Virginia Polytechnic Institute and State University   (United States)

^d NATIONAL EYE INSTITUTE   (United States)

Author keywords

Apoptosis; Fulvestrant; ICI 182780; Reactive oxygen species

Indexed keywords

ANTIESTROGEN; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; KELCH LIKE ECH ASSOCIATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ESTRADIOL; ESTROGEN RECEPTOR ALPHA, HUMAN; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; AUTOPHAGY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER GROWTH; CANCER RESISTANCE; CELL SURVIVAL; CHEMOSENSITIVITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG EFFICACY; GENE SILENCING; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; CONFOCAL MICROSCOPY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; METABOLISM; MOUSE; NUDE MOUSE; OXIDATIVE STRESS; PATHOLOGY; THEORETICAL MODEL; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; FEMALE; FLOW CYTOMETRY; HUMANS; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MODELS, THEORETICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UNFOLDED PROTEIN RESPONSE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907225947     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-247353     Document Type: Article

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