Pioglitazone normalizes insulin signaling in the diabetic rat retina through reduction in tumor necrosis factor α and suppressor of cytokine signaling 3

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26395-26405

  Jiang, Youde ^a   Thakran, Shalini ^a   Bheemreddy, Rajini ^a   Ye, Eun Ah ^a   He, Hui ^a   Walker, Robert J ^a,b   Steinle, Jena J ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b PHILANDER SMITH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; INSULIN; MACROPHAGES; OPHTHALMOLOGY; RATS; TUMORS;

DIABETIC RATS; INSULIN RESISTANCE; INSULIN SIGNALING; PIOGLITAZONE; RETINAL CELLS; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; TYPE-2 DIABETES;

SIGNALING;

INSULIN; INSULIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCOSE BLOOD LEVEL; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, RAT; PROTEIN BCL X; PROTEIN KINASE B; SOCS3 PROTEIN, RAT; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LYSATE; CELL TYPE; CONTROLLED STUDY; ELECTRORETINOGRAM; ENDOTHELIUM CELL; ENZYME ACTIVITY; INSULIN RESISTANCE; MALE; MUELLER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; RETINA; RETINA CELL; SIGNAL TRANSDUCTION; ANIMAL; BETA RHYTHM; DIABETIC RETINOPATHY; DRUG EFFECTS; DRUG SCREENING; GLUCOSE BLOOD LEVEL; INTRAOCULAR PRESSURE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; ZUCKER RAT;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BETA RHYTHM; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DRUG EVALUATION, PRECLINICAL; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTRAOCULAR PRESSURE; MALE; PHOSPHORYLATION; PPAR GAMMA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS, ZUCKER; RECEPTOR, INSULIN; RETINA; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907222557     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.583880     Document Type: Article

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