A new ibuprofen derivative inhibits platelet aggregation and ros mediated platelet apoptosis

PLoS ONE

Volumn 9, Issue 9, 2014, Pages e2718-

  Rakesh, Kodagahalli S ^a   Jagadish, Swamy ^a   Vinayaka, Ajjampura C ^a   Hemshekhar, Mahadevappa ^a   Paul, Manoj ^a   Thushara, Ram M ^a   Sundaram, Mahalingam S ^a   Swaroop, Toreshettahally R ^a   Mohan, Chakrabhavi D ^a   Basappa, ^b   Sadashiva, Marilinganadoddi P ^a   Kemparaju, Kempaiah ^a   Girish, Kesturu S ^a,c   Rangappa, Kanchugarakoppal S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b BANGALORE UNIVERSITY   (India)

^c TUMKUR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 METHYLPROPYL]PHENYL] N' (PHENYLSULFONYL)PROPANEHYDRAZIDE; CALCIMYCIN; CALCIUM ION; CASPASE; CYTOCHROME C; IBUPROFEN; IBUPROFEN DERIVATIVE; LACTATE DEHYDROGENASE; N' [[2,5 DICHLOROPHENYL]SULFONYL] 2 [4 [2 METHYLPROPYL]PHENYL]PROPANEHYDRAZIDE; N' [[4 BROMOPHENYL]SULFONYL] 2 [4 [2 METHYLPROPYL]PHENYL]PROPANEHYDRAZIDE; N' [[4 FLUOROPHENYL]SULFONYL] 2 [4 [2 METHYLPROPYL]PHENYL]PROPANEHYDRAZIDE; N' [[4 METHOXYPHENYL]SULFONYL] 2 [4 [2 METHYLPROPYL]PHENYL]PROPANEHYDRAZIDE; N' [[4 NITROPHENYL]SULFONYL] 2 [4 [2 METHYLPROPYL]PHENYL]PROPANEHYDRAZIDE; PHOSPHATIDYLSERINE; QUERCETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA; THROMBOCYTOPENIA; ANALOGS AND DERIVATIVES; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM;

APOPTOSIS; BLOOD PLATELETS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IBUPROFEN; OXIDATIVE STRESS; PLATELET AGGREGATION; REACTIVE OXYGEN SPECIES;

EID: 84907212853     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107182     Document Type: Article

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