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Volumn 9, Issue 9, 2014, Pages

Endostar, a modified recombinant human endostatin, suppresses angiogenesis through inhibition of wnt/β-catenin signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; RECOMBINANT ENDOSTATIN; VASCULOTROPIN; ENDOSTAR PROTEIN; ENDOSTATIN; RECOMBINANT PROTEIN; T CELL FACTOR PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN; WNT PROTEIN;

EID: 84907209949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107463     Document Type: Article
Times cited : (51)

References (44)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E, Wakelee H (2007) Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol 8: 15-27.
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 5
    • 34248653459 scopus 로고    scopus 로고
    • Plaque neovascularization and antiangiogenic therapy for atherosclerosis
    • Doyle B, Caplice N (2007) Plaque neovascularization and antiangiogenic therapy for atherosclerosis. J Am Coll Cardiol 49: 2073-2080.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2073-2080
    • Doyle, B.1    Caplice, N.2
  • 6
    • 49349103253 scopus 로고    scopus 로고
    • Intravitreous anti-VEGF for diabetic retinopathy: Hopes and fears for a new therapeutic strategy
    • Simo R, Hernandez C (2008) Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 51: 1574-1580.
    • (2008) Diabetologia , vol.51 , pp. 1574-1580
    • Simo, R.1    Hernandez, C.2
  • 7
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovasculariza-tion and plaque growth in apolipoprotein E-deficient mice
    • Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, et al. (1999) Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovasculariza-tion and plaque growth in apolipoprotein E-deficient mice. Circulation 99: 1726-1732.
    • (1999) Circulation , vol.99 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3    Flynn, E.4    Palinski, W.5
  • 8
    • 0035187305 scopus 로고    scopus 로고
    • Tissue examination to monitor antiangiogenic therapy: A phase i clinical trial with endostatin
    • Mundhenke C, Thomas JP, Wilding G, Lee FT, Kelzc F, et al. (2001) Tissue examination to monitor antiangiogenic therapy: a phase I clinical trial with endostatin. Clin Cancer Res 7: 3366-3374.
    • (2001) Clin Cancer Res , vol.7 , pp. 3366-3374
    • Mundhenke, C.1    Thomas, J.P.2    Wilding, G.3    Lee, F.T.4    Kelzc, F.5
  • 9
    • 32344443105 scopus 로고    scopus 로고
    • China offers alternative gateway for experimental drugs
    • Jia H, Kling J (2006) China offers alternative gateway for experimental drugs. Nat Biotechnol 24: 117-118.
    • (2006) Nat Biotechnol , vol.24 , pp. 117-118
    • Jia, H.1    Kling, J.2
  • 10
    • 84865136495 scopus 로고    scopus 로고
    • Recombinant human endostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-alpha, IL-1beta production
    • Hu W, Xia LJ, Chen FH, Wu FR, Tang J, et al. (2012) Recombinant human endostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-alpha, IL-1beta production. Inflamm Res 61: 827-835.
    • (2012) Inflamm Res , vol.61 , pp. 827-835
    • Hu, W.1    Xia, L.J.2    Chen, F.H.3    Wu, F.R.4    Tang, J.5
  • 11
    • 77955484157 scopus 로고    scopus 로고
    • Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits
    • Mao W, Kong J, Dai J, Huang ZQ, Wang DZ, et al. (2010) Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits. J Zhejiang Univ Sci B 11: 599-607.
    • (2010) J Zhejiang Univ Sci B , vol.11 , pp. 599-607
    • Mao, W.1    Kong, J.2    Dai, J.3    Huang, Z.Q.4    Wang, D.Z.5
  • 12
    • 34547106834 scopus 로고    scopus 로고
    • Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    • Ling Y, Yang Y, Lu N, You QD, Wang S, et al. (2007) Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun 361: 79-84.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 79-84
    • Ling, Y.1    Yang, Y.2    Lu, N.3    You, Q.D.4    Wang, S.5
  • 13
    • 61449159933 scopus 로고    scopus 로고
    • Endostar induces apoptotic effects in HUVECs through activation of caspase-3 and decrease of Bcl-2
    • Ling Y, Lu N, Gao Y, Chen Y, Wang S, et al. (2009) Endostar induces apoptotic effects in HUVECs through activation of caspase-3 and decrease of Bcl-2. Anticancer Res 29: 411-417.
    • (2009) Anticancer Res , vol.29 , pp. 411-417
    • Ling, Y.1    Lu, N.2    Gao, Y.3    Chen, Y.4    Wang, S.5
  • 14
    • 84855201014 scopus 로고    scopus 로고
    • Endostar down-regulates HIF-1 and VEGF expression and enhances the radioresponse to human lung adenocarcinoma cancer cells
    • Zhang L, Ge W, Hu K, Zhang Y, Li C, et al. (2012) Endostar down-regulates HIF-1 and VEGF expression and enhances the radioresponse to human lung adenocarcinoma cancer cells. Mol Biol Rep 39: 89-95.
    • (2012) Mol Biol Rep , vol.39 , pp. 89-95
    • Zhang, L.1    Ge, W.2    Hu, K.3    Zhang, Y.4    Li, C.5
  • 15
    • 77958450885 scopus 로고    scopus 로고
    • The role of wnt signaling in physiological and pathological angiogenesis
    • Dejana E (2010) The role of wnt signaling in physiological and pathological angiogenesis. Circ Res 107: 943-952.
    • (2010) Circ Res , vol.107 , pp. 943-952
    • Dejana, E.1
  • 17
    • 77954210220 scopus 로고    scopus 로고
    • An updated overview on Wnt signaling pathways: A prelude for more
    • Rao TP, Kuhl M (2010) An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 106: 1798-1806.
    • (2010) Circ Res , vol.106 , pp. 1798-1806
    • Rao, T.P.1    Kuhl, M.2
  • 18
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 19
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • Macdonald, B.T.1    Tamai, K.2    He, X.3
  • 20
    • 24044500959 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells
    • Masckauchan TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J (2005) Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis 8: 43-51.
    • (2005) Angiogenesis , vol.8 , pp. 43-51
    • Masckauchan, T.N.1    Shawber, C.J.2    Funahashi, Y.3    Li, C.M.4    Kitajewski, J.5
  • 21
    • 84858051662 scopus 로고    scopus 로고
    • Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion
    • Planutiene M, Planutis K, Holcombe RF (2011) Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion. Vasc Cell 3: 28.
    • (2011) Vasc Cell , vol.3 , pp. 28
    • Planutiene, M.1    Planutis, K.2    Holcombe, R.F.3
  • 22
    • 84861609140 scopus 로고    scopus 로고
    • In vitro and in vivo anti-angiogenic activities of Panduratin A
    • Lai SL, Cheah SC, Wong PF, Noor SM, Mustafa MR (2012) In vitro and in vivo anti-angiogenic activities of Panduratin A. PLoS One 7: e38103.
    • (2012) PLoS One , vol.7 , pp. e38103
    • Lai, S.L.1    Cheah, S.C.2    Wong, P.F.3    Noor, S.M.4    Mustafa, M.R.5
  • 23
    • 73849115202 scopus 로고    scopus 로고
    • Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
    • Wang Q, Sun ZX, Allgayer H, Yang HS (2010) Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. Oncogene 29: 128-138.
    • (2010) Oncogene , vol.29 , pp. 128-138
    • Wang, Q.1    Sun, Z.X.2    Allgayer, H.3    Yang, H.S.4
  • 24
    • 33746864818 scopus 로고    scopus 로고
    • Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling
    • Du Q, Park KS, Guo Z, He P, Nagashima M, et al. (2006) Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res 66: 7024-7031.
    • (2006) Cancer Res , vol.66 , pp. 7024-7031
    • Du, Q.1    Park, K.S.2    Guo, Z.3    He, P.4    Nagashima, M.5
  • 25
    • 77958478957 scopus 로고    scopus 로고
    • Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function
    • Cowan CE, Kohler EE, Dugan TA, Mirza MK, Malik AB, et al. (2010) Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res 107: 959-966.
    • (2010) Circ Res , vol.107 , pp. 959-966
    • Cowan, C.E.1    Kohler, E.E.2    Dugan, T.A.3    Mirza, M.K.4    Malik, A.B.5
  • 26
    • 2342430184 scopus 로고    scopus 로고
    • Vasculogenesis and angiogenesis
    • Patan S (2004) Vasculogenesis and angiogenesis. Cancer Treat Res 117: 3-32.
    • (2004) Cancer Treat Res , vol.117 , pp. 3-32
    • Patan, S.1
  • 27
    • 34547221505 scopus 로고    scopus 로고
    • Understanding the biology of angiogenesis: Review of the most important molecular mechanisms
    • Otrock ZK, Mahfouz RA, Makarem JA, Shamseddine AI (2007) Understanding the biology of angiogenesis: review of the most important molecular mechanisms. Blood Cells Mol Dis 39: 212-220.
    • (2007) Blood Cells Mol Dis , vol.39 , pp. 212-220
    • Otrock, Z.K.1    Mahfouz, R.A.2    Makarem, J.A.3    Shamseddine, A.I.4
  • 28
    • 78651433124 scopus 로고    scopus 로고
    • Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth
    • Li XQ, Shang BY, Wang DC, Zhang SH, Wu SY, et al. (2011) Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth. Cancer Lett 301: 212-220.
    • (2011) Cancer Lett , vol.301 , pp. 212-220
    • Li, X.Q.1    Shang, B.Y.2    Wang, D.C.3    Zhang, S.H.4    Wu, S.Y.5
  • 29
    • 84883227223 scopus 로고    scopus 로고
    • Antitumor effects of Endostar on non-Hodgkin's lymphoma by regulating endothelial progenitor cells through protein kinase B-dependent pathway
    • Yu D, Wu H, Yang B, Yang K, Liu H, et al. (2013) Antitumor effects of Endostar on non-Hodgkin's lymphoma by regulating endothelial progenitor cells through protein kinase B-dependent pathway. Acta Biochim Biophys Sin (Shanghai) 45: 742-748.
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , pp. 742-748
    • Yu, D.1    Wu, H.2    Yang, B.3    Yang, K.4    Liu, H.5
  • 30
    • 84867375369 scopus 로고    scopus 로고
    • Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116
    • Jin F, Ji H, Jia C, Brockmeier U, Hermann DM, et al. (2012) Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. PLoS One 7: e47161.
    • (2012) PLoS One , vol.7 , pp. e47161
    • Jin, F.1    Ji, H.2    Jia, C.3    Brockmeier, U.4    Hermann, D.M.5
  • 31
    • 33750973380 scopus 로고    scopus 로고
    • Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling
    • Goodwin AM, Sullivan KM, D'Amore PA (2006) Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Dev Dyn 235: 3110-3120.
    • (2006) Dev Dyn , vol.235 , pp. 3110-3120
    • Goodwin, A.M.1    Sullivan, K.M.2    D'Amore, P.A.3
  • 32
    • 77955977167 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    • Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, et al. (2010) The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 18: 938-949.
    • (2010) Dev Cell , vol.18 , pp. 938-949
    • Corada, M.1    Nyqvist, D.2    Orsenigo, F.3    Caprini, A.4    Giampietro, C.5
  • 33
    • 0141768242 scopus 로고    scopus 로고
    • The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    • Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, et al. (2003) The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 162: 1111-1122.
    • (2003) J Cell Biol , vol.162 , pp. 1111-1122
    • Cattelino, A.1    Liebner, S.2    Gallini, R.3    Zanetti, A.4    Balconi, G.5
  • 34
    • 77951050199 scopus 로고    scopus 로고
    • Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family
    • Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, et al. (2010) Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci USA 107: 6900-6905.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6900-6905
    • Zhang, B.1    Abreu, J.G.2    Zhou, K.3    Chen, Y.4    Hu, Y.5
  • 35
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5
  • 36
    • 0027154638 scopus 로고
    • Cyclin D1 is a nuclear protein required for cell cycle progression in G1
    • Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7: 812-821.
    • (1993) Genes Dev , vol.7 , pp. 812-821
    • Baldin, V.1    Lukas, J.2    Marcote, M.J.3    Pagano, M.4    Draetta, G.5
  • 38
    • 80053010958 scopus 로고    scopus 로고
    • Comparison of the effects of recombinant human endostatin and docetaxel on human umbilical vein endothelial cells in different growth states
    • Xu WJ, Huang C, Wang J, Jiang RC, Wang LC, et al. (2011) Comparison of the effects of recombinant human endostatin and docetaxel on human umbilical vein endothelial cells in different growth states. Chin Med J (Engl) 124: 2883-2889.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 2883-2889
    • Xu, W.J.1    Huang, C.2    Wang, J.3    Jiang, R.C.4    Wang, L.C.5
  • 39
    • 33646893508 scopus 로고    scopus 로고
    • Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    • Li Z, Wang C, Jiao X, Lu Y, Fu M, et al. (2006) Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 26: 4240-4256.
    • (2006) Mol Cell Biol , vol.26 , pp. 4240-4256
    • Li, Z.1    Wang, C.2    Jiao, X.3    Lu, Y.4    Fu, M.5
  • 40
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 41
    • 11144357806 scopus 로고    scopus 로고
    • Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: Implications for ocular angiogenesis
    • Duh EJ, Yang HS, Haller JA, De Juan E, Humayun MS, et al. (2004) Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol 137: 668-674.
    • (2004) Am J Ophthalmol , vol.137 , pp. 668-674
    • Duh, E.J.1    Yang, H.S.2    Haller, J.A.3    De Juan, E.4    Humayun, M.S.5
  • 42
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    • Zhang X, Gaspard JP, Chung DC (2001) Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61: 6050-6054.
    • (2001) Cancer Res , vol.61 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 43
    • 0038745735 scopus 로고    scopus 로고
    • Beta-Catenin regulates vascular endothelial growth factor expression in colon cancer
    • Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, et al. (2003) beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 63: 3145-3153.
    • (2003) Cancer Res , vol.63 , pp. 3145-3153
    • Easwaran, V.1    Lee, S.H.2    Inge, L.3    Guo, L.4    Goldbeck, C.5
  • 44
    • 14044278776 scopus 로고    scopus 로고
    • Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells
    • Skurk C, Maatz H, Rocnik E, Bialik A, Force T, et al. (2005) Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circ Res 96: 308-318.
    • (2005) Circ Res , vol.96 , pp. 308-318
    • Skurk, C.1    Maatz, H.2    Rocnik, E.3    Bialik, A.4    Force, T.5


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