Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion

Vascular Cell

Volumn 3, Issue , 2011, Pages

  Planutiene, Marina ^a   Planutis, Kestutis ^a   Holcombe, Randall F ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

catenin; angiogenesis; cancer; endothelial cells; invasion assay; Lef1; MMP2; siRNA; Wnt signaling pathway

Indexed keywords

BETA CATENIN; GELATINASE A; LYMPHOID ENHANCER FACTOR 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR 7; WNT PROTEIN; WNT3A PROTEIN;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL INVASION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WNT SIGNALING PATHWAY;

VERTEBRATA;

EID: 84858051662     PISSN: None     EISSN: 2045824X     Source Type: Journal    
DOI: 10.1186/2045-824X-3-28     Document Type: Article

References (38)

1. Caught up in a Wnt storm: Wnt signaling in cancer. Giles RH, van Es JH, Clevers H, Biochimica Et Biophysica Acta-Reviews on Cancer 2003 1653 1 1 24 10.1016/S0304-419X(03)00005-2 (Pubitemid 36627817)
2. Prostate cancer cells promote osteoblastic bone metastases through Wnts. Hall C, Bafico A, Dai J, Aaronson S, Keller E, Cancer Res 2005 65 17 7554 7560 16140917 (Pubitemid 41297224)
3. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Holcombe RF, Marsh JL, Waterman ML, Lin F, Milovanovic T, Truong T, Journal of Clinical Pathology-Molecular Pathology 2002 55 4 220 226 10.1136/mp.55.4.220
4. Expression of Frzb/secreted frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cell suppresses tumor growth and cellular invasiveness. Zi X, Guo Y, Simoneau A, Hope C, Xie J, Holcombe R, Hoang B, CANCER RESEARCH 2005 65 21 9762 9770 10.1158/0008-5472.CAN- 05-0103 16266997 (Pubitemid 41541453)
5. Stromal gene expression predicts clinical outcome in breast cancer. Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu G, Meterissian S, Omeroglu A, et al. Nature Medicine 2008 14 5 518 527 10.1038/nm1764 18438415 (Pubitemid 351655218)
6. Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor-An expression in non-small-cell lung cancer. Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, Ueno M, Journal of Clinical Oncology 2005 23 34 8765 8773 10.1200/JCO.2005.02.2871 16314637 (Pubitemid 46211522)
7. The role of wnt signaling in physiological and pathological angiogenesis. Dejana E, Circ Res 2010 107 8 943 952 10.1161/CIRCRESAHA.110.223750 20947863
8. Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. Planutis K, Planutiene M, Moyer MP, Nguyen AV, Perez CA, Holcombe RF, BMC Cell Biology 2007 8 Article No.: 12
9. Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Goodwin AM, Sullivan KM, D'Amore PA, Developmental Dynamics 2006 235 11 3110 3120 10.1002/dvdy.20939 17013885 (Pubitemid 44749701)
10. Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. Wright M, Aikawa M, Szeto W, Papkoff J, Biochemical and Biophysical Research Communications 1999 263 2 384 388 10.1006/bbrc.1999.1344 10491302 (Pubitemid 29467205)
11. Wnt/Frizzled signaling in angiogenesis. Zerlin M, Julius MA, Kitajewski J, Angiogenesis 2008 11 1 63 69 10.1007/s10456-008-9095-3 18253847
12. Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not. Goodwin AM, Kitajewski J, D'Amore PA, Growth Factors 2007 25 1 25 32 10.1080/08977190701272933 17454147 (Pubitemid 46672283)
13. Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. Levy L, Neuveut C, Renard CA, Charneau P, Branchereau S, Gauthier F, Van Nhieu JT, Cherqui D, Petit-Bertron AF, Mathieu D, et al. Journal of Biological Chemistry 2002 277 44 42386 42393 10.1074/jbc.M207418200 12200448 (Pubitemid 35257561)
14. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Masckauchan TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J, Angiogenesis 2005 8 1 43 51 10.1007/s10456-005-5612-9 16132617 (Pubitemid 41223838)
15. Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. Gherghe CM, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A, FASEB J 2011 25 6 1836 1843 10.1096/fj.10-172981 21321190
16. Wnt-1 signaling inhibits human umbilical vein endothelial cell proliferation and alters cell morphology. Chenga CW, Smith SK, Charnock-Jones DS, Experimental Cell Research 2003 291 2 415 425 10.1016/j.yexcr.2003.07.006 14644163 (Pubitemid 37485729)
17. Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways. Samarzija I, Sini P, Schlange T, Macdonald G, Hynes NE, Biochem Biophys Res Commun 2009 386 3 449 454 10.1016/j.bbrc.2009. 06.033 19523451
18. Endostatin causes G(1) arrest of endothelial cells through inhibition of cyclin D1. Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP, Journal of Biological Chemistry 2002 277 19 16464 16469 10.1074/jbc.M112274200 11815623 (Pubitemid 34967659)
19. FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo. Ezan J, Leroux L, Barandon L, Dufourcq P, Jaspard W, Moreau C, Allieres C, Daret D, Couffinhal T, Duplaa C, Cardiovascular Research 2004 63 4 731 738 10.1016/j.cardiores.2004.05.006 15306229 (Pubitemid 39078687)
20. Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors. Klingel S, Morath I, et al. Wnt Meeting Proceedings 2011 33
21. Functional diversity of Xenopus lymphoid enhancer factor/T-cell factor transcription factors relies on combinations of activating and repressing elements. Gradl D, König A, Wedlich D, J Biol Chem 2002 277 16 14159 14171 10.1074/jbc.M107055200 11821382 (Pubitemid 34968028)
22. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H, Science 1999 285 5435 1923 1926 10.1126/science.285. 5435.1923 10489374 (Pubitemid 29444623)
23. Regulation of -Catenin Nuclear Dynamics by GSK-3 Involves a LEF-1 Positive Feedback Loop. Jamieson C, Sharma M, Henderson BR, Traffic 2011 12 8 983 999 10.1111/j.1600-0854.2011.01207.x 21496192
24. Wnt pathway component Lef1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression. Nguyen A, Rosner A, Milovanovic T, Hope C, Planutis K, Saha B, Chaiwun B, Lin F, Imam SA, Marsh JL, et al. International Journal of Oncology 2005 27 4 949 956 16142310
25. Snail and Slug Promote Epithelial-Mesenchymal Transition through beta-Catenin-T-Cell Factor-4-dependent Expression of Transforming Growth Factor-beta 3. Medici D, Hay ED, Olsen BR, Molecular Biology of the Cell 2008 19 11 4875 4887 10.1091/mbc.E08-05-0506 18799618
26. PERMANENT CELL-LINE EXPRESSING HUMAN FACTOR-VIII-RELATED ANTIGEN ESTABLISHED BY HYBRIDIZATION. Edgell CJ, McDonald CC, Graham JB, Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1983 80 12 3734 3737 10.1073/pnas.80.12.3734 (Pubitemid 13063134)
27. Coculture methodologies for the study of Wnt signals. Planutis K, Planutiene M, Holcombe RF, Methods Mol Biol 2008 468 255 261 10.1007/978-1-59745-249-6-20 19099261
28. Wnt proteins are lipid-modified and can act as stem cell growth factors. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R, Nature 2003 423 6938 448 452 10.1038/nature01611 12717451 (Pubitemid 36626997)
29. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Wu B, Crampton S, Hughes C, Immunity 2007 26 2 227 239 10.1016/j.immuni.2006.12.007 17306568 (Pubitemid 46329437)
30. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Albini A, Benelli R, Nature Protocols 2007 2 3 504 511 10.1038/nprot.2006.466 17406614 (Pubitemid 47040014)
31. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Vacca A, Ribatti D, Presta M, Minischetti M, Iurlaro M, Ria R, Albini A, Bussolino F, Dammacco F, Blood 1999 93 9 3064 3073 10216103 (Pubitemid 29200799)
32. Wnt signaling in the vasculature. Goodwin A, D'Amore P, Angiogenesis 2002 5 1-2 1 9 12549854 (Pubitemid 36076918)
33. A new beta-catenin-dependent activation domain in T cell factor. Atcha F, Munguia J, Li T, Hovanes K, Waterman M, J Biol Chem 2003 278 18 16169 16175 10.1074/jbc.M213218200 12582159 (Pubitemid 36799739)
34. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Waterman ML, Cancer Metastasis Rev 2004 23 1-2 41 52 15000148 (Pubitemid 38228369)
35. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Davis G, Senger D, Circ Res 2005 97 11 1093 1107 10.1161/01.RES.0000191547.64391.e3 16306453
36. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Masckauchán TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, Khoo A, Tycko B, Brown AM, Kitajewski J, Mol Biol Cell 2006 17 12 5163 5172 10.1091/mbc.E06-04-0320 17035633 (Pubitemid 44907359)
37. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Ju R, Cirone P, Lin S, Griesbach H, Slusarski DC, Crews CM, Proc Natl Acad Sci USA 2010 107 15 6906 6911 10.1073/pnas.1001075107 20351293
38. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, Holcombe RF, Waterman ML, Nat Genet 2001 28 1 53 57 11326276 (Pubitemid 32405817)