Cytotoxicity and modes of action of 4′-hydroxy-2′,6′-dimethoxychalcone and other flavonoids toward drug-sensitive and multidrug-resistant cancer cell lines

Phytomedicine

Volumn 21, Issue 12, 2014, Pages 1651-1657

  Kuete, Victor ^a,b   Nkuete, Antoine H L ^b   Mbaveng, Armelle T ^b   Wiench, Benjamin ^a   Wabo, Hippolyte K ^b   Tane, Pierre ^b   Efferth, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

Anticancer; Apoptosis; Chalcones; Flavanones; Mode of action; Resistance

Indexed keywords

2',4' DIHYDROXY 2',6' DIMETHOXYCHALCONE; 4' HYDROXY 2',6' DIMETHOXYCHALCONE; ALPINETIN; ANTINEOPLASTIC AGENT; CARDAMOMIN; CHALCONE DERIVATIVE; DOXORUBICIN; FLAVONOID; MULTIDRUG RESISTANCE PROTEIN; ONYSILIN; PINOSTROBIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 4'-HYDROXY-2',6'-DIMETHOXYCHALCONE; CARDAMONIN; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CELL CYCLE G0 PHASE; CONTROLLED STUDY; CROSS RESISTANCE; CYTOTOXICITY; DRUG MECHANISM; DRUG TREATMENT FAILURE; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; TISSUE SPECIFICITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; POLYGONUM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CHALCONES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; PLANT EXTRACTS; POLYGONUM; REACTIVE OXYGEN SPECIES;

EID: 84907205285     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.08.001     Document Type: Article

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