Reduced miR-125a-5p expression is associated with gastric carcinogenesis through the targeting of E2F3

Molecular Medicine Reports

Volumn 10, Issue 5, 2014, Pages 2601-2608

  Xu, Yanjun ^a   Huang, Zhenxia ^b   Liu, Yueli ^b  

^a ZHEJIANG CANCER HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

E2F3; Gastric cancer; Invasion; Migration; MiR 125a 5p; Proliferation

Indexed keywords

MICRORNA; MICRORNA 125A 5P; TRANSCRIPTION FACTOR E2F3; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; E2F3 PROTEIN, HUMAN; MIRN125 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; BINDING SITE; CANCER GROWTH; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DISTANT METASTASIS; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC SCREENING; HUMAN; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MALE; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR INVASION; TUMOR SUPPRESSOR GENE; CARCINOGENESIS; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PATHOLOGY; RNA INTERFERENCE; STOMACH TUMOR; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; AGED; CARCINOGENESIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; E2F3 TRANSCRIPTION FACTOR; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MALE; MICRORNAS; MIDDLE AGED; RNA INTERFERENCE; STOMACH NEOPLASMS;

EID: 84907202613     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2567     Document Type: Article

References (45)

1. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
2. Calin GA, Sevignani C, Dumitru CD, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101: 2999-3004, 2004.
3. Li X, Zhang Y, Zhang Y, Ding J, Wu K and Fan D: Survival prediction of gastric cancer by a seven microRNA signature. Gut 59: 579-585, 2010.
4. Kong KL, Kwong DL, Chan TH, et al: MicroRNA 375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin like growth factor 1 receptor. Gut 61: 33-42, 2012.
5. Hsu KW, Wang AM, Ping YH, et al: Down regulation of tumor suppressor MBP 1 by microRNA 363 in gastric carcinogenesis. Carcinogenesis: Oct 4, 2013 (Epub ahead of print).
6. Peng Y, Dai Y, Hitchcock C, et al: Insulin growth factor signaling is regulated by microRNA 486, an underexpressed microRNA in lung cancer. Proc Natl Acad Sci USA 110: 15043-15048, 2013.
7. Zhang N, Wang X, Huo Q, et al: MicroRNA 30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene: Jul 15, 2013 (Epub ahead of print).
8. Volinia S, Galasso M, Sana ME, et al: Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci USA 109: 3024-3029, 2012.
9. Li D, Liu X, Lin L, et al: MicroRNA 99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem 286: 36677-36685, 2011.
10. Osada H and Takahashi T: let 7 and miR 17-92: small sized major players in lung cancer development. Cancer Sci 102: 9-17, 2011.
11. Aqeilan RI, Calin GA and Croce CM: miR 15a and miR 16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 17: 215-220, 2010.
12. Wiklund ED, Bramsen JB, Hulf T, et al: Coordinated epigenetic repression of the miR 200 family and miR 205 in invasive bladder cancer. Int J Cancer 128: 1327-1334, 2011.
13. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
14. Hohenberger P and Gretschel S: Gastric cancer. Lancet 362: 305-315, 2003.
15. Wu Q, Jin H, Yang Z, et al: MiR 150 promotes gastric cancer proliferation by negatively regulating the pro apoptotic gene EGR2. Biochem Biophys Res Commun 392: 340-345, 2010.
16. Liu T, Tang H, Lang Y, Liu M and Li X: MicroRNA 27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer Lett 273: 233-242, 2009.
17. Chan SH, Wu CW, Li AF, Chi CW and Lin WC: miR 21 microRNA expression in human gastric carcinomas and its clinical association. Anticancer Res 28: 907-911, 2008.
18. Kim YK, Yu J, Han TS, et al: Functional links between clustered microRNAs: suppression of cell cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res 37: 1672-1681, 2009.
19. Gao C, Zhang Z, Liu W, Xiao S, Gu W and Lu H: Reduced microRNA 218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 116: 41-49, 2010.
20. Luo H, Zhang H, Zhang Z, et al: Down regulated miR 9 and miR 433 in human gastric carcinoma. J Exp Clin Cancer Res 28: 82, 2009.
21. Takagi T, Iio A, Nakagawa Y, Naoe T, Tanigawa N and Akao Y: Decreased expression of microRNA 143 and 145 in human gastric cancers. Oncology 77: 12-21, 2009.
22. Ding L, Xu Y, Zhang W, et al: MiR 375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res 20: 784-793, 2010.
23. Pan J, Hu H, Zhou Z, et al: Tumor suppressive mir 663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncol Rep 24: 105-112, 2010.
24. Zhang Z, Li Z, Gao C, et al: miR 21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 88: 1358-1366, 2008.
25. Tsukamoto Y, Nakada C, Noguchi T, et al: MicroRNA 375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 70: 2339-2349, 2010.
26. Du Y, Xu Y, Ding L, et al: Down regulation of miR 141 in gastric cancer and its involvement in cell growth. J Gastroenterol 44: 556-561, 2009.
27. Jiang L, Huang Q, Chang J, Wang E and Qiu X: MicroRNA HSA miR 125a 5p induces apoptosis by activating p53 in lung cancer cells. Exp Lung Res 37: 387-398, 2011.
28. Nishida N, Mimori K, Fabbri M, et al: MicroRNA 125a 5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res 17: 2725-2733, 2011.
29. Odar K, Botjančič E, Gale N, Glavač D and Zidar N: Differential expression of microRNAs miR 21, miR 31, miR 203, miR 125a 5p and miR 125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. Histopathology 61: 257-265, 2012.
30. Kim JK, Noh JH, Jung KH, et al: Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR 125a 5p and MiR 125b. Hepatology 57: 1055-1067, 2013.
31. Fassan M, Pizzi M, Realdon S, et al: The HER2 miR125a5p/miR125b loop in gastric and esophageal carcinogenesis. Hum Pathol 44: 1804-1810, 2013.
32. Krek A, Grun D, Poy MN, et al: Combinatorial microRNA target predictions. Nat Genet 37: 495-500, 2005.
33. Lewis BP, Shih IH, Jones Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell 115: 787-798, 2003.
34. John B, Enright AJ, Aravin A, Tuschl T, Sander C and Marks DS: Human MicroRNA targets. PLoS Biol 2: e363, 2004.
35. Cooper CS, Nicholson AG, Foster C, et al: Nuclear overexpression of the E2F3 transcription factor in human lung cancer. Lung Cancer 54: 155-162, 2006.
36. Feber A, Clark J, Goodwin G, et al: Amplification and overexpression of E2F3 in human bladder cancer. Oncogene 23: 1627-1630, 2004.
37. Foster CS, Falconer A, Dodson AR, et al: Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Oncogene 23: 5871-5879, 2004.
38. Fang Y, Gu X, Li Z, Xiang J and Chen Z: miR 449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expression. Oncol Rep 30: 399-406, 2013.
39. Vimala K, Sundarraj S, Sujitha MV and Kannan S: Curtailing overexpression of E2F3 in breast cancer using siRNA (E2F3) based gene silencing. Arch Med Res 43: 415-422, 2012.
40. McClellan KA, Ruzhynsky VA, Douda DN, et al: Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle independent functions. Mol Cell Biol 27: 4825-4843, 2007.
41. Ziebold U, Reza T, Caron A and Lees JA: E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 15: 386-391, 2001.
42. Oeggerli M, Tomovska S, Schraml P, et al: E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Oncogene 23: 5616-5623, 2004.
43. Orom UA, Kauppinen S and Lund AH: LNA modified oligonucleotides mediate specific inhibition of microRNA function. Gene 372: 137-141, 2006.
44. Surdziel E, Eder M and Scherr M: Lentivirus mediated antagomir expression. Methods Mol Biol 667: 237-248, 2010.
45. Velu CS and Grimes HL: Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells. Methods Mol Biol 928: 185-195, 2012.