Encapsulation and modified-release of thymol from oral microparticles as adjuvant or substitute to current medications

Phytomedicine

Volumn 21, Issue 12, 2014, Pages 1627-1632

  Rassu, G ^a   Nieddu, M ^a   Bosi, P ^b   Trevisi, P ^b   Colombo, M ^b   Priori, D ^b   Manconi, P ^a   Giunchedi, P ^a   Gavini, E ^a   Boatto, G ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Anti infective formulations; Herbal drug encapsulation; In vivo studies; Microparticles; Modified release formulation; Thymol

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; METHYLCELLULOSE; THYMOL; MICROSPHERE; PHARMACEUTICAL VEHICLES AND ADDITIVES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; MASKING; MAXIMUM PLASMA CONCENTRATION; MICROENCAPSULATION; NONHUMAN; PALATABILITY; PARTICLE SIZE; PIGLET; PREFORMULATION; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUME OF DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; COLON; DRUG FORMULATION; INTESTINE MUCOSA; METABOLISM; SWINE;

ADJUVANTS, PHARMACEUTIC; ANIMALS; COLON; DRUG COMPOUNDING; DRUG LIBERATION; INTESTINAL MUCOSA; METHYLCELLULOSE; MICROSPHERES; PARTICLE SIZE; SWINE; THYMOL;

EID: 84907197525     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.07.017     Document Type: Article

References (29)

1. P.C. Braga, M. Dal Sasso, M. Culici, and M. Alfieri Eugenol and thymol, alone or in combination, induce morphological alterations in the envelope of Candida albicans Fitoterapia 78 2007 396 400
2. H.C.F. Carneiro, R.V. Tonon, C.R.F. Grosso, and M.D. Hubinger Encapsulation efficiency and oxidative stability of flaxseed oil microencapsulated by spray drying using different combinations of wall materials J. Food Eng. 115 2013 443 451
3. A.K. Chauhan, R. Jakhar, S. Paul, and S.C. Kang Potentiation of macrophage activity by thymol through augmenting phagocytosis Int. Immunopharmacol. 18 2014 340 346
4. A.E. Edris Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review Phytother. Res. 21 2007 308 323
5. M.C. Elissondo, P.E. Pensel, and G.M. Denegri Could thymol have effectiveness on scolices and germinal layer of hydatid cysts? Acta Trop. 125 2013 251 257
6. C.S. Favaro-Trindade, A.S. Santana, E.S. Monterrey-Quintero, M.A. Trindade, and F.M. Netto The use of spray drying technology to reduce bitter taste of casein hydrolysate Food Hydrocolloids 24 2010 336 340
7. E. Gavini, A.B. Hegge, G. Rassu, V. Sanna, C. Testa, G. Pirisino, J. Karlsen, and P. Giunchedi Nasal administration of Carbamazepine using chitosan microspheres: in vitro/in vivo studies Int. J. Pharm. 307 2006 9 15
8. E. Gavini, G. Spada, G. Rassu, G. Cerri, A. Brundu, M. Cossu, M. Sorrenti, and P. Giunchedi Development of solid nanoparticles based on hydroxypropyl-β-cyclodextrin aimed for the colonic transmucosal delivery of diclofenac sodium J. Pharm. Pharmacol. 63 2011 472 482
9. A. Gharsallaoui, G. Roudaut, O. Chambin, A. Voilley, and R. Saurel Applications of spray-drying in microencapsulation of food ingredients: an overview Food Res. Int. 40 2007 1107 1121
10. R. Hamoud, S. Zimmermann, J. Reichling, and M. Wink Synergistic interactions in two-drug and three-drug combinations (thymol, EDTA and vancomycin) against multi drug resistant bacteria including E. coli Phytomedicine 21 2014 443 447
11. S. Kamel, N. Ali, K. Jahangir, S.M. Shah, and A.A. El-Gendy Pharmaceutical significance of cellulose: a review Express Polym. Lett. 2 2008 758 778
12. T. Kulisic, A. Radonic, V. Katalinic, and M. Milos Analytical, nutritional and clinical methods use of different methods for testing antioxidative activity of oregano essential oil Food Chem. 85 2004 633 640
13. W.T. Langeveld, E.J. Veldhuizen, and S.A. Burt Synergy between essential oil components and antibiotics: a review Crit. Rev. Microbiol. 40 2014 76 94
14. E.E. Lazar-Baker, S.D. Hetherington, V.V. Ku, and S.M. Newman Evaluation of commercial essential oil samples on the growth of postharvest pathogen Monilinia fructicola (G. Winter) Honey Lett. Appl. Microbiol. 52 2010 227 232
15. C. Le-Ngoc Vo, C. Park, and B.J. Lee Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs Eur. J. Pharm. Biopharm. 85 2013 799 813
16. I.M. Martins, M.F. Barreiro, M. Coelho, and A.E. Rodrigues Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications Chem. Eng. J. 245 2014 191 200
17. J. Michiels, J. Missotten, N. Dierick, D. Fremaut, P. Maene, and S. De Smet In vitro degradation and in vivo passage kinetics of carvacrol, thymol, eugenol and trans-cinnamaldehyde along the gastrointestinal tract of piglets J. Sci. Food Agric. 88 2008 2371 2381
18. M. Nieddu, G. Rassu, G. Boatto, P. Bosi, P. Trevisi, P. Giunchedi, A. Carta, and E. Gavini Improvement of thymol properties by complexation with cyclodextrins: in vitro and in vivo studies Carbohydr. Polym. 102 2014 393 399
19. M. Oussalah, S. Caillet, L. Saucierc, and M. Lacroix Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat Meat Sci. 73 2006 236 244
20. K. Pal, A.T. Paulson, and D. Rousseau Biopolymers in controlled-release delivery systems S. Kasapis, I.T. Norton, J.B. Ubbink, Modern Biopolymer Science 2009 Academic Press London, UK 519 557
21. A. Paudel, Z.A. Worku, J. Meeus, S. Guns, and G. Van den Mooter Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations Int. J. Pharm. 453 2013 253 284
22. G. Sacchetti, S. Maietti, M. Muzzoli, M. Scaglianti, S. Manfredini, M. Radice, and R. Bruni Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods Food Chem. 91 2005 621 632
23. Y. Shoji, and H. Nakashima Nutraceutics and delivery systems J. Drug Target. 12 2004 385 391
24. A. Sokmen, M. Gulluce, A. Akpulat, D. Daferera, B. Tepe, M. Polissiou, M. Sokmen, and F. Sahin The in vitro antimicrobial and antioxidant activities of the essential oils and methanol extracts of endemic Thymus spathulifolius Food Control 15 2004 627 634
25. B. Tepe, M. Sokmen, A. Akpulat, D. Daferera, M. Polissiou, and A. Sokmen Antioxidative activity of the essential oils of Thymus sipyleus subsp. sipyleus var. sipyleus and Thymus sipyleus subsp. sipyleus var. rosulans J. Food Eng. 66 2005 447 454
26. D. Trombetta, F. Castelli, M.G. Sarpietro, V. Venuti, M. Cristani, C. Daniele, A. Saija, G. Mazzanti, and G. Bisignano Mechanisms of antibacterial action of three monoterpenes Antimicrob. Agents Chemother. 49 2005 2474 2478
27. C. Ulbricht Thyme (Thymus vulgaris L.) Thymol. J. Herb. Pharmacother. 4 2004 49 67
28. A. Wattanasatcha, S. Rengpipat, and S. Wanichwecharungruang Thymol nanospheres as an effective anti-bacterial agent Int. J. Pharm. 434 2012 360 365
29. S.M. Wong, I.W. Kellaway, and S. Murdan Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles Int. J. Pharm. 317 2006 61 68