Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Cellular and Molecular Life Sciences

Volumn 67, Issue 6, 2010, Pages 907-918

  Vinken, Mathieu ^a   Decrock, Elke ^b   De Vuyst, Elke ^b   De Bock, Marijke ^b   Vandenbroucke, Roosmarijn E ^b   De Geest, Bruno G ^b   Demeester, Joseph ^b   Sanders, Niek N ^b   Vanhaecke, Tamara ^a   Leybaert, Luc ^b   Rogiers, Vera ^a  

^a FACULTY OF MEDICINE AND PHARMACY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Apoptosis; Connexin32; Gap junction; Hemichannel; Primary hepatocyte

Indexed keywords

CONNEXIN 32; CYCLOHEXIMIDE; FAS LIGAND; GAP JUNCTION PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GAP JUNCTION; GENETIC TRANSCRIPTION; LIVER CELL; LIVER CELL CULTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; ANIMAL; CHANNEL GATING; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; NECROSIS; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CONNEXINS; CYCLOHEXIMIDE; FAS LIGAND PROTEIN; HEPATOCYTES; HUMANS; ION CHANNEL GATING; MALE; NECROSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77949527817     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0220-2     Document Type: Article

References (39)

1. Maeda S (2000) Mechanisms of active cell death in isolated hepatocytes. In: Berry MN, Edwards AM. (eds) The hepatocyte review. Kluwer, Norwell, pp 281-300
2. Malhi H, Gores GJ, Lemasters JJ (2006) Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 43:S31-S44
3. 3. Malhi H, Gores GJ (2008) Cellular and molecular mechanisms of liver injury. Gastroenterology 134:1641-1654 (Pubitemid 351615416)
4. 4.QiaoL,FarrellGC(1999)Theeffectsofcelldensity, attachmentsubstratumanddexamethasoneonspontaneousapoptosisofrathepatocytesinp rimaryculture.InVitroCellDevBiolAnim35:417-424(Pubitemid29380006)
5. 5. Vinken M, Vanhaecke T, Papeleu P, Snykers S, Henkens T, Rogiers V (2006) Connexins and their channels in cell growth and cell death. Cell Signal 18:592-600 (Pubitemid 43113290)
6. 6. Vinken M, Henkens T, De Rop E, Fraczek J, Vanhaecke T, Rogiers V (2008) Biology and pathobiology of gap junctional channels in hepatocytes. Hepatology 47:1077-1088 (Pubitemid 351449699)
7. 7. Albright CD, Kuo J, Jeong S (2001) cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Exp MoI Pathol 71:34-39 (Pubitemid 32802856)
8. 8. Krysko DV, Leybaert L, Vandenabeele P, D'Herde K (2005) Gap junctions and the propagation of cell survival and cell death signals. Apoptosis 10:459-469 (Pubitemid 40896652)
9. Contreras JE, Sanchez HA, Veliz LP, Bukauskas FF, Bennett MV, Saez JC (2004) Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev 47:290-303
10. 10. Evans WH, De Vuyst E, Leybaert L (2006) The gap junction cellular internet: connexin hemichannels enter the signaling limelight. Biochem J 397:1-14 (Pubitemid 44032830)
11. Rodriguez-Sinovas A, Cabestrero A, Lopez D, Torre I, Morente M, Abellan A, Miro E, Ruiz-Meana M, Garcia-Dorado D (2007) The modulatory effects of connexin 43 on cell death/survival beyond cell coupling. Prog Biophys Mol Biol 94:219-232
12. Plotkin LI, Manolagas SC, Bellido T (2002) Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277:8648-8657
13. Decrock E, De Vuyst E, Vinken M, Van Moorhem M, Vranck K, Wang N, Van Laeken L, De Bock M, D'Herde K, Lai CP, Rogiers V, Evans WH, Naus CC, Leybaert L (2009) Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death Differ 16:151-163
14. 14. Ramachandran S, Xie LH, John SA, Subramaniam S, Lal R (2007) A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury. PLoS ONE 2:e712 (Pubitemid 351330804)
15. Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, Sonobe Y, Mizuno T, Suzumura A (2006) Tumor necrosis factoralpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 281:21362-21368
16. Hur KC, Shim JE, Johnson RG (2003) A potential role for Cx43hemichannels in staurosporin-induced apoptosis. Cell Commun Adh.es 10:271-277
17. Kalvelyte A, Imbrasaite A, Bukauskiene A, Verselis VK, Bukauskas FF (2003) Connexins and apoptotic transformation. Biochem Pharmacol 66:1661-1672
18. Gomez-Lechon MJ, O'Connor JE, Lahoz A, Castell JV, Donato MT (2008) Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes. Curr Med Chem 15:2071-2085
19. Bai L, Wang J, Yin XM, Dong Z (2003) Analysis of apoptosis: basic principles and procedures. In: Yin XM, Dong Z (eds) Essentials of apoptosis: a guide for basic and clinical research. Humana, Totowa, NJ, pp 239-251
20. Gill GH, Dive D (2000) Apoptosis: basic mechanisms and relevance to toxicology. In: Roberts R (ed) Apoptosis in toxicology. Taylor & Francis, London, pp 1-20
21. Vandenbroucke RE, De Geest BG, Bonne S, Vinken M, Vanhaecke T, Heimberg H, Wagner E, Rogiers V, De Smedt SC, Demeester J, Sanders NN (2008) Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly (beta-am ino esters). J Gene Med 10:783-794
22. Papeleu P, Vanhaecke T, Henkens T, Elaut G, Vinken M, Snykers S, Rogiers V (2006) Isolation of rat hepatocytes. Methods Mol Biol 320:229-237
23. Fraczek J, Deleu S, Lukaszuk A, Doktorova T, Tourwe D, Geerts A, Vanhaecke T, Vanderkerken K, Rogiers V (2009) Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. Invest New Drugs 27:338-346
24. Bergmeyer HU (1974) Lactate dehydrogenase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic, New York, pp 574-579
25. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
26. Vinken M, Henkens T, Vanhaecke T, Papeleu P, Geerts A, Van Rossen E, Chipman JK, Meda P, Rogiers V (2006) Trichostatin A enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. Toxicol Sci 91:484-492
27. 27. Rouquet N, Carlier K, Briand P, Wiels J, Joulin V (1996) Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes. Biochem Biophys Res Commun 229:27-35 (Pubitemid 27013705)
28. Ni R, Tomita Y, Matsuda K, Ichihara A, Ishimura K, Ogasawara J, Nagata S (1.994) Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res 215:332-337
29. Foster JR (2000) Detection and biomarkers of apoptosis. In: Roberts R (ed) Apoptosis in toxicology. Taylor & Francis, London, pp 213-232
30. Schalper KA, Palacios-Prado N, Orellana JA, Saez JC (2008) Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes 15:207-218
31. 31.LeybaertL,BraetK,VandammeW,CabooterL,MartinPE,EvansWH(2003) Connexinchannels,connexinmimeticpeptidesandATPrelease.CellCommunAdhes10: 251-257(Pubitemid38081381)
32. 32. De Vuyst E, Decrock E, Cabooter L, Dubyak GR, Naus CC, Evans WH, Leybaert L (2006) Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J 25:34-44 (Pubitemid 43077293)
33. 33. Theiss C, Mazur A, Meiler K, Mannherz HG (2007) Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells. Exp Cell Res 313:38-52 (Pubitemid 44958452)
34. Sharrow AC, Li Y, Micsenyi A, Grisworld RD, Wells A, Monga SS, Blair HC (2008) Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL. Exp Cell Res 314:297-308
35. 35. De Vuyst E, Decrock E, De Bock M, Yamasaki H, Naus CC, Evans WH, Leybaert L (2007) Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell 18:34-46 (Pubitemid 46066708)
36. 36. Retamal MA, Froger N, Palacios-Prado N, Ezan P, Saez PJ, Saez JC, Giaume C (2007) Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci 27:13781-13792 (Pubitemid 350278255)
37. 37. Gonzales E, Prigent S, Abou-Lovergne A, Boucherie S, Tjordmann T, Jacquemin E, Combettes L (2007) Rat hepatocytes express functional P2X receptors. FEBS Lett 581:3260-3266 (Pubitemid 46977372)
38. 38. Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (2003) Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA 100:13644-13649 (Pubitemid 37444793)
39. 2+ in transfected HeLa cells. Am J Physiol Cell Physiol 197:C665-C678