Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 37, 2014, Pages 13547-13552

  Comoglio, Yannick ^a,b,c,d   Levitz, Joshua ^e   Kienzler, Michael A ^e   Lesage, Florian ^a,d,f   Isacoff, Ehud Y ^e,g   Sandoz, Guillaume ^a,b,c,d  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b CNRS   (France)

^c CENTRE DE BIOCHIMIE   (France)

^d Laboratory of Excellence in Ion Channel Science and Therapeutics   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^g INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Alcohol; K2P2.1; Micro regulatory domain; Neuron excitability; Potassium channels

Indexed keywords

5-FLUORO-2-INDOLYLDESCHLOROHALOPEMIDE; ALCOHOL DERIVATIVE; AMINO ACID; DOMPERIDONE; ENZYME INHIBITOR; INDOLE DERIVATIVE; KCNK10 PROTEIN, HUMAN; KCNK4 PROTEIN, HUMAN; MUTANT PROTEIN; PHOSPHATIDIC ACID; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; POTASSIUM CHANNEL; POTASSIUM CHANNEL PROTEIN TREK-1; PROTEIN BINDING; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; BIOLOGICAL MODEL; CHANNEL GATING; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HEK293 CELL LINE; HIPPOCAMPUS; HUMAN; METABOLISM; NERVE CELL;

ALCOHOLS; AMINO ACIDS; BIOCATALYSIS; DOMPERIDONE; ENZYME INHIBITORS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; INDOLES; ION CHANNEL GATING; MODELS, BIOLOGICAL; MUTANT PROTEINS; NEURONS; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN BINDING;

EID: 84907190440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1407160111     Document Type: Article

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