Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells

Phytomedicine

Volumn 21, Issue 12, 2014, Pages 1658-1665

  Ouyang, Liang ^a   Chen, Yi ^a   Wang, Xiao Yan ^b   Lu, Rui Feng ^b   Zhang, Shou Yue ^a   Tian, Mao ^a   Xie, Tao ^a   Liu, Bo ^a   He, Gu ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Epidermal growth factor receptor (EGFR); MCF 7 cell; Polygonatum odoratum lectin (POL)

Indexed keywords

ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PLANT LECTIN; POLYGONATUM ODORATUM LECTIN; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; LECTIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; MCF 7 CELL LINE; POLYGONATUM; POLYGONATUM ODORATUM; CHEMISTRY; DRUG EFFECTS; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; HUMANS; LECTINS; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; MITOCHONDRIA; POLYGONATUM; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84907187245     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.08.002     Document Type: Article

References (36)

1. C. Alfarano, C.E. Andrade, K. Anthony, N. Bahroos, M. Bajec, K. Bantoft, D. Betel, B. Bobechko, K. Boutilier, E. Burgess, K. Buzadzija, R. Cavero, C. D'Abreo, I. Donaldson, D. Dorairajoo, M.J. Dumontier, M.R. Dumontier, V. Earles, R. Farrall, H. Feldman, E. Garderman, Y. Gong, R. Gonzaga, V. Grytsan, E. Gryz, V. Gu, E. Haldorsen, A. Halupa, R. Haw, A. Hrvojic, L. Hurrell, R. Isserlin, F. Jack, F. Juma, A. Khan, T. Kon, S. Konopinsky, V. Le, E. Lee, S. Ling, M. Magidin, J. Moniakis, J. Montojo, S. Moore, B. Muskat, I. Ng, J.P. Paraiso, B. Parker, G. Pintilie, R. Pirone, J.J. Salama, S. Sgro, T. Shan, Y. Shu, J. Siew, D. Skinner, K. Snyder, R. Stasiuk, D. Strumpf, B. Tuekam, S. Tao, Z. Wang, M. White, R. Willis, C. Wolting, S. Wong, A. Wrong, C. Xin, R. Yao, B. Yates, S. Zhang, K. Zheng, T. Pawson, B.F. Ouellette, and C.W. Hogue The biomolecular interaction network database and related tools 2005 update Nucleic Acids Res. 33 2005 D418 D424
2. Y. Cheng, H. Li, X. Ren, T. Niu, W.N. Hait, and J. Yang Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition PLoS One 5 2010 e9715
3. Y. Cheng, F. Qiu, S. Tashiro, S. Onodera, and T. Ikejima ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic MCF-7 cell death Biochem. Biophy. Res. Commun. 376 2008 483 488
4. Y. Cheng, F. Qiu, Y.C. Ye, S. Tashiro, S. Onodera, and T. Ikejima Oridonin induces induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma MCF-7 cells Arch. Biochem. Biophys. 490 2009 70 75
5. Y. Cheng, F. Qiu, Y.C. Ye, Z.M. Guo, S. Tashiro, S. Onodera, and T. Ikejima Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma MCF-7 cells FEBS J. 276 2009 1291 1306
6. E.G. De Mejía, and V.I. Prisecaru Lectins as bioactive plant proteins: a potential in cancer treatment Crit. Rev. Food Sci. Nutr. 45 2005 425 445
7. L.L. Fu, Y. Yang, H.L. Xu, Y. Cheng, X. Wen, L. Ouyang, J.K. Bao, Y.Q. Wei, and B. Liu Identification of novel caspase/autophagy-related gene switch to cell fate decisions in breast cancer Cell Prolif. 46 2013 67 75
8. B. Heike, I.H. Engels, V. Wolfgang, S.O. Klaus, and W. Sebastian Mistletoe lectin activates caspase-8/flice independently of death receptor signaling and enhances anticancer drug-induced apoptosis Cancer Res. 59 1999 2083 2090
9. L.L. Fu, C.C. Zhou, S. Yao, J.Y. Yu, B. Liu, and J.K. Bao Plant lectins: targeting programmed cell death pathways as anti-tumor agents Int. J. Biochem. Cell Biol. 43 2011 1442 1449
10. K. Hostanska, V. Vuong, S. Rocha, M.S. Soengas, C. Glanzmann, R. Saller, S. Bodis, and M. Pruschy Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation Br. J. Cancer 88 2003 1785 1793
11. S. Kerrien, Y. Alam-Faruque, B. Aranda, I. Bancarz, A. Bridge, C. Derow, E. Dimmer, M. Feuermann, A. Friedrichsen, R. Huntley, C. Kohler, J. Khadake, C. Leroy, A. Liban, C. Lieftink, L. Montecchi-Palazzi, S. Orchard, J. Risse, K. Robbe, B. Roechert, D. Thorneycroft, Y. Zhang, R. Apweiler, and H. Hermjakob IntAct - open source resource for molecular interaction data Nucleic Acids Res. 35 2007 D561 D565
12. W.H. Kim, W.B. Park, B. Gao, and M.H. Jung Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells Mol. Pharmacol. 66 2004 1383 1396
13. M.S. Kima, J. Leeb, K.M. Leec, S.H. Yanga, S. Choid, S.Y. Chungd, T.Y. Kima, W.H. Jeongf, and R. Parka Involvement of hydrogen peroxide in mistletoe lectin-II-induced apoptosis of myeloleukemic U937 cells Life Sci. 73 2003 1231 1243
14. C.Y. Li, L. Meng, B. Liu, and J.K. Bao Galanthus nivalis agglutinin (GNA)-related lectins: traditional proteins, burgeoning drugs? Curr. Chem. Biol. 3 2009 324 333
15. C.Y. Li, H.L. Xu, B. Liu, and J.K. Bao Concanavalin A, from an old protein to novel candidate anti-neoplastic drug Curr. Mol. Pharmacol. 3 2010 37 42
16. B. Liu, H.J. Bian, and J.K. Bao Plant lectins: potential antineoplastic drugs from Bench to Clinic Cancer Lett. 287 2010 1 12
17. B. Liu, C.Y. Li, H.J. Bian, M.W. Min, L.F. Chen, and J.K. Bao Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells Arch. Biochem. Biophys. 482 2009 1 6
18. B. Liu, M.W. Min, and J.K. Bao Induction of apoptosis by concanavalin A and its molecular mechanisms in cancer cells Autophagy 5 2009 432 433
19. B. Liu, H. Peng, Q. Yao, J. Li, E.J. Van Damme, J. Balzarini, and J.K. Bao Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities Phytomedicine 16 2009 601 608
20. B. Liu, B. Zhang, M.W. Min, H.J. Bian, L.F. Chen, Q. Liu, and J.K. Bao Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma MCF-7 cells Biochem. Biophys. Acta 1790 2009 840 844
21. G.R. Mishra, M. Suresh, K. Kumaran, N. Kannabiran, S. Suresh, P. Bala, K. Shivakumar, N. Anuradha, R. Reddy, T.M. Raghavan, S. Menon, G. Hanumanthu, M. Gupta, S. Upendran, S. Gupta, M. Mahesh, B. Jacob, P. Mathew, P. Chatterjee, K.S. Arun, S. Sharma, K.N. Chandrika, N. Deshpande, K. Palvankar, R. Raghavnath, R. Krishnakanth, H. Karathia, B. Rekha, R. Nayak, G. Vishnupriya, H.G. Kumar, M. Nagini, G.S. Kumar, R. Jose, P. Deepthi, S.S. Mohan, T.K. Gandhi, H.C. Harsha, K.S. Deshpande, M. Sarker, T.S. Prasad, and A. Pandey Human protein reference database - 2006 update Nucleic Acids Res. 34 2006 D411 D414
22. K.N. Mukesh, A.M. Meredith, Y.F. Felix, and S.L. Theodore Integration of EGFR inhibitors with radiochemotherapy Nat. Rev. Cancer 6 2006 876 885
23. M. Persico, A. Ceol, C. Gavrila, R. Hoffmann, A. Florio, and G. Cesareni HomoMINT: an inferred human network based on orthology mapping of protein interactions discovered in model organisms BMC Bioinform. 6 Suppl 4 2005 S21
24. A.R.M. Ruhul Amin, K.P. Rajib, S.T. Vijay, and L.A. Munna A Novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin Concanavalin A. Cancer Res. 67 2007 5617 5621
25. V.S. Sreenath, W.B. Daphne, S. Jeffrey, and A.H. Daniel Epidermal growth factor receptor mutations in lung cancer Nat. Rev. Cancer 7 2007 169 181
26. K.J. Taylor, A.H. Sims, L. Liang, D. Faratian, M. Muir, G. Walker, B. Kuske, J.M. Dixon, D.A. Cameron, D.J. Harrison, and S.P. Langdon Dynamic changes in gene expression in vivo predictprognosis of tamoxifen-treated patients with breast cancer Breast Cancer Res. 12 2010 R39
27. Q. Tian, W. Wang, C. Miao, H. Peng, B. Liu, and F.W. Leng Purification, characterization and molecular cloning of a novel mannose-binding lectin from rhizomes of Ophiopogon japonicus with antiviral and antifungal activities Plant Sci. 175 2008 877 884
28. E.J. Van Damme, W.J. Peumans, A. Barre, and P. RougÍe Plant lectins: a composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles Crit. Rev. Plant Sci. 17 1998 575 692
29. E.J. Van Damme, N. Lannoo, and W.J. Peumans Plant Lectins Adv. Botanical. Res. 48 2008 107 209
30. E.J. Van Damme, S. Nakamura-Tsuruta, D.F. Smith, M. Ongenaert, H.C. Winter, P. Rougé, I.J. Goldstein, H. Mo, J. Kominami, R. Culerrier, A. Barre, and J. Hirabayashi Peumans WJ. Phylogenetic and specificity studies of two-domain GNA-related lectins: generation of mutispecificity through domain duplication and devergent evolution Biochem. J. 404 2007 51 61
31. N. Wang, H.L. Xu, X. Zhao, X. Wen, F.T. Wang, S.Y. Wang, L.L. Fu, B. Liu, and J.K. Bao Network-based identification of novel connections among apoptotic signaling pathways in cancer Appl. Biochem. Biotechnol. 167 2012 621 631
32. S.Y. Wang, Q.J. Yu, J.K. Bao, and B. Liu Polygonatum cyrtonema lectin: a potential antineoplastic drug targeting programmed cell death pathways Biochem. Biophys. Res. Commun. 40 2011 497 500
33. A.G. Winter, J. Wildenhain, and M. Tyers BioGRID REST Service, BiogridPlugin2 and BioGRID WebGraph: new tools for access to interaction data at BioGRID Bioinformatics 27 2011 1043 1044
34. Y. Yang, H.L. Xu, Z.T. Zhang, J.J. Liu, W.W. Li, H. Ming, and J.K. Bao Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities Phytomedicine 18 2011 748 755
35. Q.J. Yu, Z.Y. Li, S. Yao, M. Ming, S.Y. Wang, B. Liu, and J.K. Bao In silico analysis of molecular mechanisms of GNA-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis Appl. Biochem. Biotechnol. 165 2011 1037 1046
36. T. Zhang, N. Xie, W.F. He, R. Liu, Y.L. Lei, H. Tan, B. Liu, C.H. Huang, and Y.Q. Wei An integrated proteomics and bioinformatics analyses of Hepatitis B Virus X protein and identification of a novel interactor apoA-I J. Proteomics 84 2013 92 105